Organometallic Oxidation Catalysis

Volume 22 of the series Topics in Organometallic Chemistry pp 191-240


Homogeneous Copper-Catalyzed Oxidations

  • Jarl Ivar van der VlugtAffiliated withInstitut für Anorganische Chemie, Georg-August-Universität Göttingen
  • , Franc MeyerAffiliated withInstitut für Anorganische Chemie, Georg-August-Universität Göttingen Email author 

* Final gross prices may vary according to local VAT.

Get Access


The bioinorganic chemistry of copper has provided a stimulating background for exciting research on homogeneous copper-catalyzed reactions in recent years, and this review starts with a brief and concise overview of the role of copper containing active sites in metalloproteins that catalyze oxidation or oxygenation reactions in nature. Efficient bio-inspired Cu-based catalysts for a variety of chemical oxidative transformations have been developed over the last decade, with oxygen as the prime oxidant of choice, and several prominent examples are presented in this review. Selected contributions with (organic) peroxides or other oxygen-transfer agents are described as well. Key themes discussed in this review include the oxidation of alkanes, alcohols, amines and phenols as well as oxidative coupling or polymerization reactions with phenols. Focus is placed on the results obtained in catalysis and the mechanistic studies undertaken to support these results; therefore, less emphasis is given to more fundamental coordination chemistry aspects of the Cu-complexes described as well as their spectroscopic characteristics.
Biomimetic dioxygen reactivity Copper Coupling reactions Homogeneous catalysis Oxidation chemistry