Chapter

Biosynthesis

Volume 195 of the series Topics in Current Chemistry pp 93-142

Date:

Cofactor Biosynthesis: A Mechanistic Perspective

  • Tadhg P. BegleyAffiliated withDepartment of Chemistry, Cornell University
  • , Cynthia KinslandAffiliated withDepartment of Chemistry, Cornell University
  • , Sean TaylorAffiliated withDepartment of Chemistry, Cornell University
  • , Manish TandonAffiliated withDepartment of Chemistry, Cornell University
  • , Robb NicewongerAffiliated withDepartment of Chemistry, Cornell University
  • , Min WuAffiliated withDepartment of Chemistry, Cornell University
  • , Hsiu-Ju ChiuAffiliated withDepartment of Chemistry, Cornell University
  • , Neil KelleherAffiliated withDepartment of Chemistry, Cornell University
  • , Nino CampobassoAffiliated withDepartment of Chemistry, Cornell University
    • , Yi ZhangAffiliated withDepartment of Chemistry, Cornell University

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Abstract

The chemistry of the cofactors has provided a fertile area of overlap between organic chemistry and biochemistry, and the organic chemistry of the cofactors is now a thoroughly studied area. In contrast, the chemistry of cofactor biosynthesis is still relatively underdeveloped. In this review the biosynthesis of nicotinamide adenine dinucleotide, riboflavin, folate, molyb-dopterin, thiamin, biotin, lipoic acid, pantothenic acid, coenzyme A, S-adenosylmethionine, pyridoxal phosphate, ubiquinone and menaquinone in E. coli will be described with a focus on unsolved mechanistic problems.

Keywords

Cofactor vitamin E. coli biosynthesis mechanism