Chapter

Biosynthesis

Volume 209 of the series Topics in Current Chemistry pp 53-95

Date:

Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and Diterpenes

  • Edward M. DavisAffiliated withInstitute of Biological Chemistry, Washington State University
  • , Rodney CroteauAffiliated withInstitute of Biological Chemistry, Washington State University

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Abstract

Terpene synthases catalyze the first committed steps in the biosynthesis of monoterpenes, sesquiterpenes, and diterpenes. An overview is presented of the enzymology and mechanism of these terpene synthases, and their molecular cloning, expression, and sequence analysis. Detailed structural and functional evaluation of four representative monoterpene, sesquiterpene, and diterpene synthases is also presented.

Keywords

Terpene Monoterpene Sesquiterpene Diterpene Cyclase Geranyl diphosphate Farnesyl diphosphate Geranylgeranyl diphosphate