Cross-Coupling Reactions

Volume 219 of the series Topics in Current Chemistry pp 11-59


Organoboron Compounds

  • Norio MiyauraAffiliated withDivision of Molecular Chemistry, Graduate School of Engineering, Hokkaido University

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Until recently, organoboronic acids had found limited use in organic synthesis due to their low reactivity for ionic reactions. However, it became increasingly clear that they are a valuable reagent capable of undergoing many catalytic carbon-carbon bond formations in organic syntheses including asymmetric synthesis, combinatorial synthesis, and polymer synthesis. A review of the metal-catalyzed cross-coupling reaction of these compounds is presented here with particular emphasis on their application in selective organic syntheses. Representative methods for achieving selective coupling are outlined, along with a survey of a wide range of C-C bond formations.


Cross-coupling reaction Organoboron compounds Palladium and nickel catalysts Carbon-carbon bond formation