Cross-Coupling Reactions

Volume 219 of the series Topics in Current Chemistry pp 1-9


Introduction to Cross-Coupling Reactions

  • Kohei Tamao Affiliated withInstitute for Chemical Research, Kyoto University Uji
  • , Norio MiyauraAffiliated withDivision of Molecular Chemistry, Graduate School of Engineering, Hokkaido University

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The cross-coupling reaction of organometallic reagents with organic electrophiles in the presence of group 8– 10 metal catalysts, notably nickel and palladium complexes, is the method of choice for a wide range of C-C, C-H, C-N, C-O, C-S, C-P or C-M bond-forming process [1]. These reactions, now accessible with a variety of organometallic reagents and electrophiles, provide a common class of synthetic transformations, commonly referred to as “cross-coupling reactions” (Eq. 1).