Proteins at Solid-Liquid Interfaces

Part of the series Principles and Practice pp 23-49

From Kinetics to Structure: High Resolution Molecular Microscopy

  • Jeremy J. RamsdenAffiliated withDepartment of Materials, Cranfield University

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Existing methods of protein structural determination either present a static picture under unnatural conditions or impose a considerable perturbation on the molecule during measurement. This chapter introduces high resolution optical waveguide lightmode spectroscopy (OWLS) as an alternative non-imaging technique of great power and versatility enabling the structure and dynamics of proteins at interfaces to be characterized with unprecedented richness and precision.