Chapter

DNA Methylation: Basic Mechanisms

Volume 301 of the series Current Topics in Microbiology and Immunology pp 179-201

Establishment and Maintenance of DNA Methylation Patterns in Mammals

  • T. ChenAffiliated withEpigenetics Program, Novartis Institutes for Biomedical Research
  • , E. LiAffiliated withEpigenetics Program, Novartis Institutes for Biomedical Research

* Final gross prices may vary according to local VAT.

Get Access

Abstract

In mammals, CpG methylation patterns are established and maintained during development by the Dnmt1 and Dnmt3 families of DNA methyltransferases. These enzymes share conserved catalytic motifs in their C-terminal regions, but have unique N-terminal regulatory domains. Studies over the past several years have shed light on the molecular mechanisms by which DNA methylation patterns are regulated. This review focuses on recent advances in defining the functional domains of DNA methyltransferases and identifying interacting proteins that may contribute to the functional specializations of these enzymes.