Chapter

Reoviruses: Entry, Assembly and Morphogenesis

Volume 309 of the series Current Topics in Microbiology and Immunology pp 189-219

Rotavirus Proteins: Structure and Assembly

  • J. B. PesaventoAffiliated withVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
  • , S. E. CrawfordAffiliated withDepartment of Molecular Virology and Microbiology, Baylor College of Medicine
  • , M. K. EstesAffiliated withDepartment of Molecular Virology and Microbiology, Baylor College of Medicine
  • , B. V. Venkataram PrasadAffiliated withVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine Email author 

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Abstract

Rotavirus is a major pathogen of infantile gastroenteritis. It is a large and complex virus with a multilayered capsid organization that integrates the deter minants of host specificity, cell entry, and the enzymatic functions necessary for endogenous transcription of the genome that consists of 11 dsRNA segments. These segments encode six structural and six nonstructural proteins. In the last few years, there has been substantial progress in our understanding of both the structural and functional aspects of a variety of molecular processes involved in the replication of this virus. Studies leading to this progress using of a variety of structural and biochemical techniques including the recent application of RNA interference technology have uncovered several unique and intriguing features related to viral morphogenesis. This review focuses on our current understanding of the structural basis of the molecular processes that govern the replication of rotavirus.