Can Unresolved Infection Precipitate Autoimmune Disease?
- D. J. B. MarksAffiliated withCentre for Molecular Medicine, University College London
- , N. A. MitchisonAffiliated withDepartment of Immunology, Windeyer Institute of Medical Science, University College London
- , A. W. SegalAffiliated withCentre for Molecular Medicine, University College London
- , J. SieperAffiliated withDepartment of Rheumatology, Charite Berlin, Campus Benjamin Franklin
Autoimmune diseases are frequently postulated to arise as post-infectious phenomena. Here we survey the evidence supporting these theories, with particular emphasis on Crohn’s disease and ankylosing spondylitis. Direct proof that infection establishes persistent autoimmunity remains lacking, although it may provoke a prolonged inflammatory response when occurring on a susceptible immunological background. The argument of infective causality is by nomeans trivial, since it carries important consequences for the safety of vaccine development.
- Can Unresolved Infection Precipitate Autoimmune Disease?
- Book Title
- Current Concepts in Autoimmunity and Chronic Inflammation
- pp 105-125
- Print ISBN
- Online ISBN
- Series Title
- Current Topics in Microbiology and Immunology
- Series Volume
- Series ISSN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- Additional Links
- Industry Sectors
- eBook Packages
- Editor Affiliations
- 10. Deutsches Rheumaforschungszentrum Berlin (DRFZ)
- 11. National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Author Affiliations
- 12. Centre for Molecular Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK
- 13. Department of Immunology, Windeyer Institute of Medical Science, University College London, 46 Cleveland Street, London, W1T 4JF, UK
- 14. Department of Rheumatology, Charite Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
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