Chapter

CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

Volume 293 of the series Current Topics in Microbiology and Immunology pp 287-302

Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity

  • T. NomuraAffiliated withDepartment of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University
  • , S. SakaguchiAffiliated withDepartment of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University

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Abstract

Naturally arising regulatory T (TR) cells, represented by CD25+CD4+ TR cells, play an essential role in maintaining immunological self-tolerance. This T cell-mediated dominant control of the immune response not only inhibits the development of autoimmune disease, but also impedes effective immunosurveillance against autologous tumor cells. Attenuation of TR cell-mediated immune suppression can therefore evoke effective tumor immunity in otherwise nonresponsive animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited when devising a novel immunotherapy for cancer.