The influence of mild hypothermia on ICP, CPP and outcome in patients with primary and secondary brain injury
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Aim of this study was to examine the hypothesis that only a subgroup of patients with lesser primary brain damage after severe head injury may benefit from therapeutic hypothermia.
We prospectively analysed 72 patients with severe head injury, randomized into groups with (n=37) and without (n=35) hypothermia of 34°C maintained for 72 hours. The influence of hypothermia on ICP, CPP and neurological outcome was analysed in the context of the extent of primary brain damage.
Patients with normothermia and primary lesions (n=17) — values: GCS on admission 5 (median), ICP 18.9 (mean), CPP 73 (mean), GOS 4 (median). Patients with normothermia and extracerebral hematomas (n=20): GCS 4, ICP 16, CPP 71, GOS 3. Patients with hypothermia and primary lesions (n=21): GCS 4,62, ICP 10,81, CPP 78,1, GOS 4. Patients with hypothermia and extracerebral hematomas (n=14): GCS 5, ICP 13.2, CPP 78, GOS 5.
Hypothermia decreased ICP and increased CPP regardless of the type of brain injury. Hypothermia was not able to improve outcome in patients with primary brain lesions but this pilot study suggests that it significantly improves outcome in patients with extracerebral hematomas.
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- The influence of mild hypothermia on ICP, CPP and outcome in patients with primary and secondary brain injury
- Book Title
- Intracranial Pressure and Brain Monitoring XII
- pp 273-275
- Print ISBN
- Online ISBN
- Series Title
- Acta Neurochirurgica Supplementum
- Series Volume
- Series ISSN
- Springer Vienna
- Copyright Holder
- Additional Links
- Severe head injury
- primary and secondary brain damage
- mild hypothermia
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- Editor Affiliations
- 1. Prince of Wales Hospital, The Chinese University of Hong Kong
- 2. Medical College of Virginia Commonwealth University
- 3. Academisch Ziekenhuis Dijkzigt, Erasmus University Rotterdam
- 4. Addenbrooke’s Hospital, University of Cambridge
- 5. School of Medicine, Nihon University
- Author Affiliations
- 6. Neurosurgical Department, University Hospital Brno, Jihlavská 20, 625 00, Brno, Czech Republic
- 7. Anaesthesiological Department, University Hospital Brno, Brno, Czech Republic
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