Advances in Polymer Science Volume 240, 2011, pp 103-134
Date: 10 Jun 2010

Self-Assembled Monolayers as Dynamic Model Substrates for Cell Biology

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In recent years, the surface chemistry community has actively pursued the design and generation of stimuli-responsive platforms or dynamic surfaces to control the interface between cells and a solid support. Surface properties can be manipulated through photoactivation, electrochemical potential, pH change, and the addition of a biochemical signal, with the aim of mimicking the extracellular matrix and inducing cellular behavior. This chapter describes recent advances in the development and utility of self-assembled monolayers (SAMs) as dynamic, model substrates for cell biology.