Chapter

Electronic and Magnetic Properties of Chiral Molecules and Supramolecular Architectures

Volume 298 of the series Topics in Current Chemistry pp 189-236

Date:

Vibrational Circular Dichroism Spectroscopy of Chiral Molecules

  • Guochun YangAffiliated withDepartment of Chemistry, University of Alberta
  • , Yunjie XuAffiliated withDepartment of Chemistry, University of Alberta Email author 

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Abstract

In this chapter, new developments and main applications of vibrational circular dichroism (VCD) spectroscopy reported in the last 5 years are described. This includes the determinations of absolute configurations of chiral molecules, understanding solvent effects and modeling solvent–solute explicit hydrogen bonding networks using induced solvent chirality, studies of transition metal complexes and their peculiar and enormous intensity enhancements in VCD spectra, investigations of conformational preference of chiral ligands bound to gold nano particles, and two new advances in applying matrix isolation VCD spectroscopy to flexible, multi-conformational chiral molecules and complexes, and in development of femtosecond laser based VCD instruments for transient VCD monitoring. A brief review of the experimental techniques and theoretical methods is also given. The purpose of this chapter is to provide an up-to-date perspective on the capability of VCD to solve significant problems about chiral molecules in solution, in thin film states, or on surfaces.

Keywords

Absolute configuration and conformation determinations Density functional theory Induced solvent chirality Transient VCD measurements Vibrational circular dichroism