Date: 04 Nov 2006

Preferential Crystallization

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Abstract

This contribution focuses primarily on chiral discrimination in the solid state, i.e. the formationof conglomerates, how to detect them and the various benefits that can be retrieved from chiral recognitionin crystal lattices.

The core of the work is devoted to phase diagrams (mainly binary and ternary). The stable and metastableheterogeneous equilibria are depicted and used to understand different variants of preferential crystallizationand how the entrainment effect proceeds. Seeded and auto-seeded processes are analyzed minutely. The seedingprocedure has a significant impact on the control of stereoselective secondary nucleation and crystalgrowth.

The review ends with a systematic analysis of the reasons that can put, sometimes, severe limitationson the entrainment effect.