Chapter

Supramolecular Chirality

Volume 265 of the series Topics in Current Chemistry pp 47-88

Date:

Dynamic Helical Structures: Detection and Amplification of Chirality

  • Katsuhiro MaedaAffiliated withDepartment of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University
  • , Eiji YashimaAffiliated withDepartment of Molecular Design and Engineering, Graduate School of Engineering, Nagoya UniversityYashima Super-Structured Helix Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST) Email author 

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Abstract

A unique feature of dynamic helical, chromophoric macromolecules that enables the detection of a small imbalance in chiral guest molecules through a noncovalent bonding interaction with high cooperativity is described. In sharp contrast to host–guest and supramolecular systems based on small synthetic receptor molecules, the chiral information of nonracemic guest molecules transfers with a significant amplification in a helical polymer as an excess of a single-handed helix, resulting in a highly efficient chirality-sensing system. Helical aggregates with controlled helicity based on small molecules and their chiral amplification and use in chirality sensing are also briefly described in this review.

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Chiral amplification Chirality sensing Helical aggregates Helical macromolecules Helix