SABIO-RK: Integration and Curation of Reaction Kinetics Data
- Cite this paper as:
- Wittig U. et al. (2006) SABIO-RK: Integration and Curation of Reaction Kinetics Data. In: Leser U., Naumann F., Eckman B. (eds) Data Integration in the Life Sciences. DILS 2006. Lecture Notes in Computer Science, vol 4075. Springer, Berlin, Heidelberg
Simulating networks of biochemical reactions require reliable kinetic data. In order to facilitate the access to such kinetic data we have developed SABIO-RK, a curated database with information about biochemical reactions and their kinetic properties. The data are manually extracted from literature and verified by curators, concerning standards, formats and controlled vocabularies. This process is supported by tools in a semi-automatic manner. SABIO-RK contains and merges information about reactions such as reactants and modifiers, organism, tissue and cellular location, as well as the kinetic properties of the reactions. The type of the kinetic mechanism, modes of inhibition or activation, and corresponding rate equations are presented together with their parameters and measured values, specifying the experimental conditions under which these were determined. Links to other databases enable the user to gather further information and to refer to the original publication. Information about reactions and their kinetic data can be exported to an SBML file, allowing users to employ the information as the basis for their simulation models.
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