A Compositional Approach to the Stochastic Dynamics of Gene Networks

  • Luca Cardelli
Conference paper

DOI: 10.1007/11539452_3

Part of the Lecture Notes in Computer Science book series (LNCS, volume 3653)
Cite this paper as:
Cardelli L. (2005) A Compositional Approach to the Stochastic Dynamics of Gene Networks. In: Abadi M., de Alfaro L. (eds) CONCUR 2005 – Concurrency Theory. CONCUR 2005. Lecture Notes in Computer Science, vol 3653. Springer, Berlin, Heidelberg

Abstract

We propose a compositional approach to the dynamics of gene regulatory networks based on the stochastic π-calculus, and develop a representation of gene network elements which can be used to build complex circuits in a transparent and efficient way. To demonstrate the power of the approach we apply it to several artificial networks, such as the repressilator and combinatorial gene circuits first studied in Combinatorial Synthesis of Genetic Networks [GEHL2002]. For two examples of the latter systems, we point out how the topology of the circuits and the interplay of the stochastic gate interactions influence the circuit behavior. Our approach may be useful for the testing of biological mechanisms proposed to explain the experimentally observed circuit dynamics.

Joint work with Ralf Blossey and Andrew Phillips.

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Luca Cardelli
    • 1
  1. 1.Microsoft ResearchCambridgeUnited Kingdom

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