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Early Nutrition and its Later Consequences: New Opportunities

Volume 569 of the series Advances in Experimental Medicine and Biology pp 109-113

Effect of N-3 Polyunsaturated Fatty Acid Supplementation in Pregnancy: The Nuheal Trial

  • Tamás DecsiAffiliated withDepartment of Paediatrics, University of Pécs
  • , Cristina CampoyAffiliated withDepartment of Paediatrics, University of Granada
  • , Berthold KoletzkoAffiliated withDr. von Haunersches Kinderspital, University of Munich

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Abstract

In this placebo controlled, randomised, double blind trial, pregnant women received from the 20th week of gestation onwards either 500 mg docosahexaenoic acid (DHA), 400 mg 5-methyl-tetra-hydro-folate (5-MTHF), or placebo, or a combination of 500 mg DHA and 400 mg 5-MTHF. The dietary supplements were well tolerated; the dropout rates did not differ significantly in the active arms of the study (10% to 19%) from that seen in the placebo group (13%). DHA supplementation resulted in significant enhancement of the contribution of DHA to maternal, placental and venous cord blood lipids.

Key words

Docosahexaenoic acid fetal nutrition long-chain polyunsaturated fatty acid methyl-tetra-hydro-folate pregnancy