Early Nutrition and its Later Consequences: New Opportunities

Volume 569 of the series Advances in Experimental Medicine and Biology pp 109-113

Effect of N-3 Polyunsaturated Fatty Acid Supplementation in Pregnancy: The Nuheal Trial

  • Tamás DecsiAffiliated withDepartment of Paediatrics, University of Pécs
  • , Cristina CampoyAffiliated withDepartment of Paediatrics, University of Granada
  • , Berthold KoletzkoAffiliated withDr. von Haunersches Kinderspital, University of Munich

* Final gross prices may vary according to local VAT.

Get Access


In this placebo controlled, randomised, double blind trial, pregnant women received from the 20th week of gestation onwards either 500 mg docosahexaenoic acid (DHA), 400 mg 5-methyl-tetra-hydro-folate (5-MTHF), or placebo, or a combination of 500 mg DHA and 400 mg 5-MTHF. The dietary supplements were well tolerated; the dropout rates did not differ significantly in the active arms of the study (10% to 19%) from that seen in the placebo group (13%). DHA supplementation resulted in significant enhancement of the contribution of DHA to maternal, placental and venous cord blood lipids.

Key words

Docosahexaenoic acid fetal nutrition long-chain polyunsaturated fatty acid methyl-tetra-hydro-folate pregnancy