Inhibitors of NF-κB Activity

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A part from being a paradigm for understanding cellular signaling, the NF-κB pathway has been thoroughly investigated over the last two decades due to its involvement in a number of human diseases. In the post genomic era, improved knowledge and novel technologies have contributed immensely to the discovery of several hitherto unknown cellular processes that regulate NF-κB. Identification of covalent modifications of many NF-κB pathway components, both in the cytoplasm and the nucleus has shed light on novel mechanisms that regulate NF-κB activity. Similarly, study of a number of cellular and viral proteins that regulate this pathway has added to our understanding of the molecular mechanisms and molecular targets in the NF-κB pathway for drug development.