Chapter

Polyomaviruses and Human Diseases

Volume 577 of the series Advances in Experimental Medicine and Biology pp 274-287

The Polyomavirus, JCV, and Its Involvement in Human Disease

  • Kamel KhaliliAffiliated withCenter for Neurovirology and Cancer Biology, Temple University
  • , Jennifer GordonAffiliated withCenter for Neurovirology and Cancer Biology, Temple University
  • , Martyn K. WhiteAffiliated withCenter for Neurovirology and Cancer Biology, Temple University

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Abstract

The human neurotropic polyomavirus, JC virus (JCV), is the etiologic agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system that occurs mainly in immunosuppressed patients. JCV has also been found to be associated with human tumors of the brain and other organs. In this chapter, we describe JC virus and its role in human diseases.