DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis
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The biological significance of the new DPIV family members DP8 and DP9 is unknown. In order to obtain correlations between cell behaviors and peptidase expression levels, DP8 and DP9 overexpression in transfected cells was quantified by expressing green fluorescent protein fusion proteins. We found that, like DPIV and FAP, cells overexpressing DP8 and DP9 exhibit behavioral changes in the presence of ECM components. We demonstrated that these effects were independent of enzyme activity, and of the RGD motif that occurs in DP9. This study is the first indication of some similarities as well as differences between DP8, DP9, DPIV and FAP in their cell biological roles.
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- DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis
- Book Title
- Dipeptidyl Aminopeptidases
- Book Subtitle
- Basic Science and Clinical Applications
- Book Part
- Topic II
- pp 63-72
- Print ISBN
- Online ISBN
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- Series ISSN
- Springer US
- Copyright Holder
- Springer Science+Business Media, Inc.
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- Editor Affiliations
- 1. Otto-von-Guericke University
- Author Affiliations
- 2. A. W. Morrow Gastroenterology and Liver Centre at Royal Prince Alfred Hospital, Centenary Institute of Cancer Medicine and Cell Biology and The Discipline of Medicine, University of Sydney, Sydney, New South Wales, Australia
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