Skip to main content
SpringerLink
Log in
Book cover

Malignant Mesothelioma pp 527–542Cite as

Differentiating Sarcomas from Mesotheliomas

  • Chapter

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Battifora H, McCaughey WTE. Tumor and pseudotumors of the serosal membrane. In: Rosai J, Sobin L, eds. Atlas of Tumor Pathology, 3rd ed. Washington DC: Armed Forces Institute of Pathology, 1995:37–47.

    Google Scholar 

  2. Hurlimann J. Desmin and neural marker expression in mesothelioma cells and mesothelioma. Hum Pathol 1994;25:753–757.

    Article  PubMed  CAS  Google Scholar 

  3. Mayall FG, Goddard H, Gibbs AR. Intermediate filament expression in mesotheliomas: leiomyoid mesotheliomas are not uncommon. Histopathology 1992;21:453–457.

    PubMed  CAS  Google Scholar 

  4. Yousem SA, Hochholzer L. Malignant mesotheliomas with osseous and cartilaginous differentiation. Arch Pathol Lab Med 1987;111:62–66.

    PubMed  CAS  Google Scholar 

  5. Roggli JL, Colbeck J, Sanfilipo F, et al. Pathology of human mesothelioma. Aetiologic and diagnostic consideration. Pathol Ann 1987;22:91–131.

    Google Scholar 

  6. Woodruff JM, Christiansen WN. Glandular peripheral nerve sheath tumors. Cancer 1993;72:3618–3628.

    Article  PubMed  CAS  Google Scholar 

  7. Moran CA, Suster S, Koss MN. Smooth muscle tumours presenting as pleural neoplasms. Histopathology 1995;27:227–234.

    PubMed  CAS  Google Scholar 

  8. Nicholson AG, Goldstraw P, Fisher C. Synovial sarcoma of the pleura and its differentiation from other primary pleural tumours: a clinicopathological and immunohistochemical review of three cases. Histopathology 1998;33:508–513.

    Article  PubMed  CAS  Google Scholar 

  9. Attanoos RL, Dallimore NS, Gibbs AR. Primary epithelioid haemangioendothelioma of the peritoneum: an unusual mimic of mesothelioma. Histopathology 1997;30:375–377.

    Article  PubMed  CAS  Google Scholar 

  10. Lin B, Colby T, Gown AM, et al. Malignant vascular tumors of the serous membranes mimicking mesothelioma. Am J Surg Pathol 1996;20:1431–1439.

    Article  PubMed  CAS  Google Scholar 

  11. McCaughey WTE, Dardick I, Barr JR. Angiosarcoma of serous membranes. Arch Pathol Lab Med 1983;107:304–307.

    PubMed  CAS  Google Scholar 

  12. Wong WW, Pluth JR, Grado GL, Schild SE, Sanderson DR. Liposarcoma of the pleura. Mayo Clin Proc 1994;69:882–885.

    PubMed  CAS  Google Scholar 

  13. Carter D, Otis CN. Three types of spindle cell tumors of the pleura. Fibroma, sarcoma, and sarcomatoid mesothelioma. Am J Surg Pathol 1988;12:747–753.

    PubMed  CAS  Google Scholar 

  14. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura. Am J Surg Pathol 1989;13:640–658.

    PubMed  CAS  Google Scholar 

  15. Moran CA, Suster S, Koss MN. The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura. Semin Diagn Pathol 1992;9:169–180.

    PubMed  CAS  Google Scholar 

  16. Luppi G, Cesinaro AM, Zoboli A, Morandi U, Piccinini L. Mesenchymal chondrosarcoma of the pleura. Eur Respir J 1996;9:840–843.

    Article  PubMed  CAS  Google Scholar 

  17. Chernow B, Sahn SA. Carcinomatous involvement of the pleura. An analysis of 96 patients. Am J Med 1977;63:695–702.

    Article  PubMed  CAS  Google Scholar 

  18. Battifora H. The pleura. In: Sternberg SS, ed. Diagnostic Surgical Pathology, vol 1. New York: Raven Press, 1989:829–855.

    Google Scholar 

  19. Montag AG, Pinkus GS, Corson JM. Keratin protein immunoreactivity of sarcomatoid and mixed types of diffuse malignant mesotheliomas: an immunoperoxidase study of 30 cases. Hum Pathol 1988;19:336–342.

    PubMed  CAS  Google Scholar 

  20. Al-Izzi M, Thurlow NP, Corrin B. Pleural mesothelioma of connective tissue type, localized fibrous tumour of the pleura, and reactive submesothelial hyperplasia: an immunohistochemical comparison. J Pathol 1989;157:41–44.

    Article  Google Scholar 

  21. Azumi N, Battifora H, Carlson G, et al. Sarcomatous mesothelioma of pleura: immunohistochemical study. Lab Invest 1989;60:4.

    Google Scholar 

  22. Blobel GA, Moll R, Franke WW, et al. The intermediate filament cytoskeleton of malignant mesotheliomas and its diagnostic significance. Am J Pathol 1985;121:235–247.

    PubMed  CAS  Google Scholar 

  23. Mayall FG, Goddard H, Gibbs AR. The diagnostic implications of variable cytokeratin expression in mesotheliomas. J Pathol 1993;170:165–168.

    Article  PubMed  CAS  Google Scholar 

  24. Wirth PR, Legler J, Wright GL. Immunohistochemical evaluation of seven monoclonal antibodies for differentiation of pleural mesothelioma from lung adenocarcinoma. Cancer 1991;67:655–662.

    Article  PubMed  CAS  Google Scholar 

  25. Brown DC, Theaker JM, Banks PM, et al. Cytokeratin expression in smooth muscle and smooth muscle tumours. Histopathology 1987;11:477–486.

    PubMed  CAS  Google Scholar 

  26. Miettinen M, Lehto VP, Virtanen I. Keratin in the epithelial-like cells of classic biphasic synovial sarcoma. Virchow Arch 1982;40:157–161.

    Article  CAS  Google Scholar 

  27. Smith TA, Machen SK, Fisher C, Goldblum JR. Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor. Am J Clin Pathol 1999;112:641–648.

    PubMed  CAS  Google Scholar 

  28. Bishop PW, Menasce LP, Yates AJ, et al. An immunophenotypic survey of malignant melanomas. Histopathology 1993;23:159–166.

    PubMed  CAS  Google Scholar 

  29. Zarbo RJ, Gown AM, Nagle RB, et al. Anomalous cytokeratin expression in malignant melanoma: one-and two-dimensional Western blot analysis and immunohistochemical survey of 100 melanomas. Mod Pathol 1990;3:494–501.

    PubMed  CAS  Google Scholar 

  30. Moran CA, Travis WD, Rosado-de-Christenson ML, Koss ML, Rosai J. Thymomas presenting as pleural tumors: report of eight cases. Am J Surg Pathol 1992;16:138–144.

    PubMed  CAS  Google Scholar 

  31. Payne CB, Morningstar WA, Chester EH. Thymoma of the pleura masquerading as diffuse mesothelioma. Am Rev Respir Dis 1966;94:441–446.

    PubMed  Google Scholar 

  32. Shih D, Wang J, Tseng H, et al. Primary pleural thymoma. Arch Pathol Lab Med 1997;121:79–82.

    PubMed  CAS  Google Scholar 

  33. Chan JK, Tsang WY, Seneviratne S, Pau MY. The MIC2 antibody 013. Practical application for the study of thymic epithelial tumors. Am J Surg Pathol 1995;10:1115–1123.

    Google Scholar 

  34. Brocheriou I, Carnot F, Briere J. Immunohistochemical detection of bcl-2 protein in thymoma. Histopathology 1995;27:251–255.

    PubMed  CAS  Google Scholar 

  35. Robertson PB, Neiman RS, Worapongpaiboon S, John K, Orazi A. 013 (CD99) positivity in hematologic proliferations correlates with TdT positivity. Mod Pathol 1997;10:277–282.

    PubMed  CAS  Google Scholar 

  36. Oury TD, Hammar SP, Roggli VL. Ultrastructual features of diffuse malignant mesotheliomas. Hum Pathol 1998;29:1382–1392.

    Article  PubMed  CAS  Google Scholar 

  37. Amble FR, Olsen KD, Nascimento AG, Foote RL. Head and neck synovial sarcoma. Otolaryngol Head Neck Surg 1992;107:631–637.

    PubMed  CAS  Google Scholar 

  38. Grayson W, Nayler SJ, Jena GP. Synovial sarcoma of the parotid gland. A case report with clinicopathologic analysis and review of the literature. A Afr J Surg 1998;36:32–34.

    CAS  Google Scholar 

  39. Shmookler BM, Enzinger FM, Brannon RB. Orofacial synovial sarcoma. A clinicopathologic study of 11 new cases and review of the literature. Cancer 1982;50:267–276.

    Article  Google Scholar 

  40. Cataldi A, Orlassino R, Novero D. Synovial sarcoma of the mediastinum. Report of a case. Radiol Med 1994;87:719–721.

    CAS  PubMed  Google Scholar 

  41. Peoch M, LeMarchardour F, Bost F, et al. Primary pulmonary sarcoma of the mediastinum. A case report with immunohistochemistry, ultrastructural, and cytogenetic study. Ann Pathol 1995;15:203–206.

    CAS  Google Scholar 

  42. Witkin GB, Miettinen M, Rosai J. Abiphasic tumor of the mediastinum with feature of synovial sarcoma. A report of four cases. Am J Surg Pathol 1989;13:490–499.

    PubMed  CAS  Google Scholar 

  43. Hisaoka M, Hashimoro H, Iwamasa T, Ishikawa K, Aoki T. Primary synovial sarcoma of the lung: report of two cases confirmed by molecular detection of SYT-SSX fusion gene transcripts. Histopathology 1999;34:205–210.

    Article  PubMed  CAS  Google Scholar 

  44. Kaplan MA, Goodsman MD, Satish J, Bhagavan BS, Travis WD. Primary pulmonary sarcoma with morphologic features of monophasic synovial sarcoma and chromosome translocation t(X;18). Am J Clin Pathol 1996;105:195–199.

    PubMed  CAS  Google Scholar 

  45. Keel SB, Bacha E, Mark EJ, Nielsen SP, Rosenberg AE. Primary pulmonary sarcoma: a clinicopathologic study of 26 cases. Mod Pathol 1999;12:1124–1131.

    PubMed  CAS  Google Scholar 

  46. Koss M, Travis W, Moran C. Pulmonary sarcomas, blastoma, carcinosarcomas, and teratomas. In: Hasleton PS, ed. Spencer’s Pathology of the Lung, 5th ed. New York: McGraw Hill, 1996:1065–1109.

    Google Scholar 

  47. Roberts CA, Seemayer TA, Neff JR, Alonso A, Nelson M, Bridge JA. Translocation (X;18) in primary synovial sarcoma of the lung. Cancer Genet Cytogenet 1996;88:49–52.

    Article  PubMed  CAS  Google Scholar 

  48. Yoon GS, Park SY, Kang GH, Kim OJ. Primary pulmonary sarcoma with morphologic features of biphasic synovial sarcoma: a case report. J Korean Med Sci 1998;13:71–76.

    PubMed  CAS  Google Scholar 

  49. Nicholson AG, Rigby M, Lincoln C, Meller S, Fisher C. Synovial sarcoma of the heart. Histopathology 1997;30:349–352.

    Article  PubMed  CAS  Google Scholar 

  50. Billings SD, Meisner LF, Cummings DW, Tejada E. Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the (X;18) translocation by fluorescence in situ hybridization. Mod Pathol 2000;13:68–76.

    Article  PubMed  CAS  Google Scholar 

  51. Nielson GP, Shaw PA, Rosenberg AE, Dickersin GR, Young RH, Scully RE. Synovial sarcoma of the vulva: a report of two cases. Mod Pathol 1996;9:970–974.

    Google Scholar 

  52. Gaertner E, Zeren H, Colby TV, et al. Biphasic synovial sarcomas arising in the pleural cavity: a clinicopathologic study of five cases. Am J Surg Pathol 1996;20:36–45.

    Article  PubMed  CAS  Google Scholar 

  53. Jawahar DA, Vuletin JC, Gorecki P, et al. Primary biphasic synovial sarcoma of the pleura. Respir Med 1997;91:568–570.

    Article  PubMed  CAS  Google Scholar 

  54. Essary LR, Vargas SO, Fletcher CDM. Primary pleuropulmonary synovial sarcoma: reappraisal of a recently described anatomic subset. Cancer 2002;94:459–469.

    Article  PubMed  Google Scholar 

  55. Zeren H, Moran CA, Suster S, Fishback NF, Koss MN. Primary pulmonary sarcomas with features of monophasic synovial sarcomas: a clinicopathological, immunohistochemical, and ultrastructural study of 25 cases. Hum Pathol 1995;26:474–480.

    Article  PubMed  CAS  Google Scholar 

  56. Chilosi M, Facchetti F, Tos APD, et al. bcl-2 expression in pleural and extrapleural solitary fibrous tumours. J Pathol 1997;181:362–367.

    Article  PubMed  CAS  Google Scholar 

  57. Dei Tos AP, Wadden C, Calonje E, et al. Immunohistochemical demonstration of glycoprotein p30/32MIC2 (CD99) in synovial sarcoma. A potential cause of diagnostic confusion. Appl Immunohistochem 1995;3:168–173.

    CAS  Google Scholar 

  58. Segers K, Ramael M, Singh SK, et al. Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesothelium. Virchows Arch 1994;424:631–634.

    Article  PubMed  CAS  Google Scholar 

  59. Stevenson AJ, Chatten J, Bertoni F, Miettinen M. (p30/32MIC2) neuroectodermal/Ewing’s sarcoma antigen as an immunohistochemical marker: review of more than 600 tumors and the literature experience. Appl Immunohistochem 1994;2:231–240.

    Google Scholar 

  60. Fisher C. Synovial sarcoma: ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors. Hum Pathol 1986;17:996–1008.

    PubMed  CAS  Google Scholar 

  61. Limon J, Mrozek K, Mandahl N, et al. Cytogenetics of synovial sarcoma. Presentation of 10 new cases and review of the literature. Genes Chromosomes Cancer 1991;3:338–345.

    PubMed  CAS  Google Scholar 

  62. Smith S, Reeves BR, Wong L, Fisher C. A consistent chromosome translocation in synovial sarcoma. Cancer Genet Cytogenet 1987;26:179–180.

    Article  PubMed  CAS  Google Scholar 

  63. Falconieri G, Bussani R, Mirra M, Zanella M. Pseudomesotheliomatous angiosarcoma: a pleuropulmonary lesion simulating malignant pleural mesothelioma. Histopathology 1997;30:419–424.

    Article  PubMed  CAS  Google Scholar 

  64. Zhang PJ, Livolsi VA, Brooks JJ. Malignant epithelioid vascular tumors of the pleura: a report of a series and literature review. Hum Pathol 2000;31:29–34.

    Article  PubMed  CAS  Google Scholar 

  65. Gray MH, Rosenberg AE, Dickersin GR, et al. Cytokeratin expression in epithelioid vascular neoplasms. Hum Pathol 1990;21:212–217.

    Article  PubMed  CAS  Google Scholar 

  66. Klemperer P, Rabin CB. Primary neoplasms of the pleura. Report of five cases. Arch Pathol 1937;11:385–412.

    Google Scholar 

  67. Burrig KF, Kastendieck H. Ultrastructural observations on the histogenesis of localized fibrous tumors of the pleura (benign mesothelioma). Virchows Arch 1984;403:413–424.

    Article  CAS  Google Scholar 

  68. Scharifker D, Kaneko M. Localized fibrous “mesothelioma” of pleura (submesothelial fibroma): a clinicopathologic study of 18 cases. Cancer 1979;43:627–635.

    Article  PubMed  CAS  Google Scholar 

  69. Dotan ZA, Mor Y, Olchovsky D, et al. Solitary fibrous tumor presenting as perirenal mass associated with hypoglycemia. J Urol 1999;162:2087–2088.

    Article  PubMed  CAS  Google Scholar 

  70. Brunnemann RB, Ro JY, Ordonez NG, Mooney J, El Naggar AK, Ayala AG. Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol 1999;12:1034–1042.

    PubMed  CAS  Google Scholar 

  71. Mentzel T, Bainbridge TC, Katenkamp D. Solitary fibrous tumor: clinicopathological, immunohistochemical, and ultrastructural analysis of 12 cases arising in soft tissues, nasal cavity and nasopharynx, urinary bladder and prostate. Virchows Arch 1997;430:445–453.

    Article  PubMed  CAS  Google Scholar 

  72. Nielson GP, O’Connell JX, Rosenberg AE. Solitary fibrous tumor of soft tissue: a report of 15 cases, including 5 malignant examples with light microscopic, immunohistochemical, and ultrastructural data. Mod Pathol 1997;10:1028–1037.

    Google Scholar 

  73. Suster S, Nascimento AG, Mietinnen M, Sickel JZ, Moran CA. Solitary fibrous tumors of soft tissue. A clinicopathologic and immunohistochemical study of 12 cases. Am J Surg Pathol 1995;19:1257–1266.

    Article  PubMed  CAS  Google Scholar 

  74. Renshaw AA. 013 (CD99) in spindle cell tumors. Reactivity with hemangiopericytoma, solitary fibrous tumor, synovial sarcoma, and meningioma but rarely with sarcomatoid mesothelioma. Appl Immunohistochem 1995;3:250–256.

    Google Scholar 

  75. Suster S, Fisher C, Moran CA. Expression of bcl2 oncoprotein in benign and malignant spindle cell tumors of soft tissue, skin, serosal surfaces, and gastrointestinal tract. Am J Surg Pathol 1998;22:863–872.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Advocate Lutheran General Hospital, Park Ridge, IL, USA

    Oliver Kim MD

  2. Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA

    Thomas Krausz MD (Director of Anatomic Pathology)

Authors
  1. Oliver Kim MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas Krausz MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Thoracic Oncology, Barbara Ann Karmanos Cancer Institute, Harper University Hospital, USA

    Harvey I. Pass MD (Chief and Professor of Surgery and Oncology) (Chief and Professor of Surgery and Oncology)

  2. Wayne State University School of Medicine, Detroit, MI, 48201, USA

    Harvey I. Pass MD (Chief and Professor of Surgery and Oncology) (Chief and Professor of Surgery and Oncology)

  3. Nevada Cancer Institute, USA

    Nicholas J. Vogelzang MD (Director and Clinical Professor) (Director and Clinical Professor)

  4. Department of Internal Medicine, University of Nevada School of Medicine, Las Vegas, NV, 81935, USA

    Nicholas J. Vogelzang MD (Director and Clinical Professor) (Director and Clinical Professor)

  5. Thoracic Oncology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA

    Michele Carbone MD, PhD (Professor of Pathology, Director) (Professor of Pathology, Director)

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Kim, O., Krausz, T. (2005). Differentiating Sarcomas from Mesotheliomas. In: Pass, H.I., Vogelzang, N.J., Carbone, M. (eds) Malignant Mesothelioma. Springer, New York, NY. https://doi.org/10.1007/0-387-28274-2_35

Download citation

  • DOI: https://doi.org/10.1007/0-387-28274-2_35

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-22949-2

  • Online ISBN: 978-0-387-28274-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation