Chapter

Biomedical EPR, Part A: Free Radicals, Metals, Medicine, and Physiology

Volume 23 of the series Biological Magnetic Resonance pp 197-228

EPR Spectroscopy of Function In Vivo

Origins, Achievements, And Future Possibilities
  • Harold M. SwartzAffiliated withDepartment of Diagnostic Radiology, Dartmouth Medical School
  • , Nadeem KhanAffiliated withDepartment of Diagnostic Radiology, Dartmouth Medical School

Abstract

EPR can be used to study free radicals in vivo, environmental and biophysical parameters in cells and tissues, and to report metabolism, physiology, and biochemistry. The authors have attempted to judge which of these types of measurements will be productive for studies in animals and in humans. It is envisioned that a large number of in vivo applications of EPR will grow in importance as well as in technical capability in the near future. The most likely clinical applications will be oximetry and radiation dosimetry.