Chapter

The Link Between Inflammation and Cancer

Volume 130 of the series Cancer Treatment and Research pp 103-124

The Role of Immune Cells in the Tumor Microenvironment

  • Theresa L. WhitesideAffiliated withUniversity of Pittsburgh Cancer Institute

Abstract

Interactions between tumor infiltrating leukocytes and tumor cells have been of great interest because of the possibility that immune cells either interfere with tumor progression or actively promote tumor growth. The tumor microenvironment is shaped by cells entering it, and their functions reflect the local conditions. Successive changes occurring at the tumor site during tumor progression resemble chronic inflammation. This chronic inflammatory reaction seems to be largely orchestrated by the tumor, and it seems to promote tumor survival. Molecular and cellular mechanisms linking the inflammatory reaction and cancer are emerging, and this review summarizes the current understanding of interactions between inflammatory and cancer cells in the tumor microenvironment.

Keywords

TIL immune evasion immune surveillance inflammation cancer