Chapter

Dipeptidyl Aminopeptidases in Health and Disease

Volume 524 of the series Advances in Experimental Medicine and Biology pp 3-17

Dipeptidyl Peptidase IV Substrates

An update on in vitro peptide hydrolysis by human DPPIV
  • Ingrid De MeesterAffiliated withDepartment of Pharmaceutical Sciences, University of Antwerp
  • , Anne-Marie LambeirAffiliated withDepartment of Pharmaceutical Sciences, University of Antwerp
  • , Paul ProostAffiliated withRega Institute of Medical Science, Catholic University of Leuven
  • , Simon ScharpéAffiliated withDepartment of Pharmaceutical Sciences, University of Antwerp

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Conclusions

Many bioactive peptides qualify to be DPPIV substrates. Considering the ubiquitous presence of the enzyme - on cells, on vesicles, in fluids - it is hardly surprising that many of them are indeed found truncated in vivo. However, not all substrates are cleaved with the same efficiency. The molecular properties of DPPIV involved in substrate recognition are still poorly understood.