Cellular Peptidases in Immune Functions and Diseases 2

Volume 477 of the series Advances in Experimental Medicine and Biology pp 349-378

Review: Peptidases and Peptidase Inhibitors in the Pathogenesis of Diseases

Disturbances in the ubiquitin-mediated proteolytic system. Protease-Antiprotease imbalance in inflammatory reactions. Role of cathepsins in tumour progression
  • Ute BankAffiliated withInstitute of Immunology, Otto-von-Guericke-University
  • , Sabine KrügerAffiliated withInstitute of Pathology, Otto-von-Guericke-University
  • , Jürgen LangnerAffiliated withState University of New York at BuffaloInstitute for Medical Immunology, Martin Luther University
  • , Albert RoessnerAffiliated withInstitute of Pathology, Otto-von-Guericke-University

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With this review we wanted to present three aspects of proteinases in diseases, namely (i) the newly energing involvement of the ubiquitin mediated proteolysis system in a growing number of clinical manifestations; (ii) the importance of the fine tuning of the delicate balance of PMN proteases and their inhibitors in inflammatory diseases and (iii) the very special effects exerted by lysosomal cysteine proteinases on tumour metastasis and progression. In all three topics during the last few years have been published surprising new results leading to better understanding of the normal and pathologic functions influenced by proteolytic enzymes. It is easy to forecast the continuation of this process, and this makes one curious what might be the next steps of discovery in this field.