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Long-Range Charge Transfer in DNA I pp 187–204Cite as

Excess Electron Transfer in Defined Donor-Nucleobase and Donor-DNA-Acceptor Systems

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Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 236))

Abstract

The transfer of positive charge through DNA has been investigated in great detail over the last couple of years. In this area, major new mechanistic insights have been gained using defined acceptor modified DNA strands. Transport of exon electrons, in contrast, is much less well-explored. Our current mechanistic understanding is based on EPR spectroscopic studies of DNA material reduced using solvated electrons. Herein we report the development of defined donor-acceptor modified DNA double strands which allow the study of excess electron transfer with high precision. The model mimics the DNA repair process of DNA photolyases: they contain a reduced and deprotonated flavin as a light-triggered electron donor and a thymine dimer as the electron acceptor. The dimer performs a cycloreversion upon single electron reduction, which translates the electron capture event into a readily detectable strand break signal. Investigations with these model systems allowed us to clarify that electrons hop through DNA using pyrimidine bases as stepping stones.

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Authors and Affiliations

  1. Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35032, Marburg, Germany

    Christoph Behrens, Michaela K. Cichon, Friederike Grolle, Ulrich Hennecke & Thomas Carell

Authors
  1. Christoph Behrens
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  2. Michaela K. Cichon
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  3. Friederike Grolle
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  4. Ulrich Hennecke
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  5. Thomas Carell
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Correspondence to Thomas Carell .

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G.B. Schuster

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© 2004 Springer-Verlag Berlin Heidelberg

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Behrens, C., Cichon, M.K., Grolle, F., Hennecke, U., Carell, T. (2004). Excess Electron Transfer in Defined Donor-Nucleobase and Donor-DNA-Acceptor Systems. In: Schuster, G. (eds) Long-Range Charge Transfer in DNA I. Topics in Current Chemistry, vol 236. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b94416

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  • DOI: https://doi.org/10.1007/b94416

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20127-4

  • Online ISBN: 978-3-540-39880-6

  • eBook Packages: Springer Book Archive

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