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Molecular Chaperones as Mediators of Stress Protective Effect of Plant Adaptogens

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Heat Shock Proteins and Whole Body Physiology

Part of the book series: Heat Shock Proteins ((HESP,volume 5))

Abstract

The ability of plant adaptogens to enhance the “state of non-specific resistance” of an organism to stress by augmenting resistance to physical, biological, chemical and psychological stresses, and increasing concentration, performance and endurance during fatigue have placed it in a unique position among medicinal plants. However, the molecular mechanism by which plant adaptogens exerts its beneficial effects is thus far incompletely understood. This chapter focuses on recent advances in the understanding the molecular mechanism exerted by ADAPT-232 forte, a plant adaptogens consisting of a fixed combination of three extracts of Eleutherococcus senticocus, Schisandra chinensis and Rhodiola rosea. Our studies suggest that ADAPT-232 exerts its beneficial effect, in part, by a mechanism dependent on the upregulation of Hsp70 expression. A concise discussion of the effect of adaptogens on endurance and a comparison of hormetins and adaptogens will also be discussed

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Abbreviations

DAF-16:

forkhead box O transcription factor protein

daf-16 :

forkhead box O transcription factor gene

HPA:

hypothalamic-pituitary-adrenal

HSF-1:

heat shock factor-1 protein

hsf-1 :

heat shock factor-1 gene

Hsp72:

seventy kilo Dalton stress-inducible heat shock protein

IGF-I:

insulin-like growth factor 1

JNK:

c-Jun N-terminal kinase

JKK:

c-Jun N-terminal kinase kinase

LD:

lethal dose

NADPH:

nicotinamide adenine dinucleotide phosphate

NOAEL:

no observable adverse effect level

RNAi:

RNA interference

TNF-α:

tumor necrosis factor-alpha

TTE:

time taken to exhaustion

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Acknowledgements

This work was supported in part by the Swedish Herbal Institute Research and Development, Sweden (to A.P.), the USA National Institutes of Health/National Cancer Institutes grant RO1CA91889, institutional support from Scott & White Memorial Hospital and Clinic, Texas A&M Health Science Center College of Medicine, the Central Texas Veterans Health Administration and an Endowment from the Cain Foundation (to A.A).

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Authors and Affiliations

  1. Swedish Herbal Institute Research and Development, Spårvägen 2, SE-432 96, Åskloster, Sweden

    Alexander Panossian & Georg Wikman

  2. Swedish Herbal Institute Research and Development, Åskloster, Sweden

    Alexander Panossian

  3. Division of Investigative Pathology, The Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and Clinic, Temple, TX, USA

    Punit Kaur & Alexzander Asea

Authors
  1. Alexander Panossian
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  2. Georg Wikman
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  3. Punit Kaur
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  4. Alexzander Asea
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Editors and Affiliations

  1. College of Medicine, Texas A & M University System, South 1st St. 1901, Temple, 76508, U.S.A.

    Alexzander A. A. Asea

  2. Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Koebenhavn, 2100, Denmark

    Bente K. Pedersen

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Panossian, A., Wikman, G., Kaur, P., Asea, A. (2010). Molecular Chaperones as Mediators of Stress Protective Effect of Plant Adaptogens. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_20

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