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Bacterial CpG-DNA Licenses TLR9

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Book cover Toll-Like Receptor Family Members and Their Ligands

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 270))

Abstract

The family of Toll-like receptors (TLRs) plays an important role in the innate immune response to pathogens. TLRs sense pathogen associated molecular patterns (PAMP) and lead to the stimulation of immune cells. In man, so far ten members (TLR1-10) have been reported. This review focuses on TLR9 which is an essential component for the recognition of bacterial CpG-DNA. Expression of TLR9 and structural consideration as well as direct ligand interaction of TLR9 and CpG-DNA are discussed.

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Authors and Affiliations

  1. Hygiene and Immunology, Institute for Medical Microbiology, Trogerstrasse 9, 81675, Munich, Germany

    S. Bauer & H. Wagner

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  1. S. Bauer
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  2. H. Wagner
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Editors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, 10550 N. Torreye Pines Road, 92037, La Jolla, California, USA

    Bruce Beutler M.D.

  2. Institut für Medizinische Mikrobiologie, Immunologie and Hygiene Technische Universität München, Trogerstr. 9, 81675, München, Germany

    Hermann Wagner

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© 2002 Springer-Verlag Berlin Heidelberg

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Bauer, S., Wagner, H. (2002). Bacterial CpG-DNA Licenses TLR9. In: Beutler, B., Wagner, H. (eds) Toll-Like Receptor Family Members and Their Ligands. Current Topics in Microbiology and Immunology, vol 270. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59430-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-59430-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63975-3

  • Online ISBN: 978-3-642-59430-4

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