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Toll-Like Receptor Family Members and Their Ligands pp 155–164Cite as

MyD88 as a Bottle Neck in Toll/IL-1 Signaling

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 270))

Abstract

Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiates the signaling cascade that leads to the activation of nuclear factor-кB and mitogen-activated protein kinases. Analysis of MyD88-deficient mice revealed its essential role in TLR/IL-1R signaling as well as in both the innate and the adaptive immune response.

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Authors and Affiliations

  1. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    O. Takeuchi & S. Akira

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  1. O. Takeuchi
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  2. S. Akira
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Editors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, 10550 N. Torreye Pines Road, 92037, La Jolla, California, USA

    Bruce Beutler M.D.

  2. Institut für Medizinische Mikrobiologie, Immunologie and Hygiene Technische Universität München, Trogerstr. 9, 81675, München, Germany

    Hermann Wagner

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© 2002 Springer-Verlag Berlin Heidelberg

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Takeuchi, O., Akira, S. (2002). MyD88 as a Bottle Neck in Toll/IL-1 Signaling. In: Beutler, B., Wagner, H. (eds) Toll-Like Receptor Family Members and Their Ligands. Current Topics in Microbiology and Immunology, vol 270. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59430-4_10

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  • DOI: https://doi.org/10.1007/978-3-642-59430-4_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63975-3

  • Online ISBN: 978-3-642-59430-4

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