Abstract
The aim of this research is to investigate, in a screening population, the relationship between mammographic density and tumour characteristics including size, invasiveness and mammographic features. Mammograms of 105 women with screen detected breast cancer were analysed; 111 lesions were identified. Volumetric density measurements were obtained using QuantaTM and VolparaTM. Histological information was extracted from the screening database and radiological features were assessed by two expert breast radiologists. Statistical analysis was performed using Mann-Whitney U test and Spearman’s rank order correlation. The median percentage density by VolparaTM of women with invasive cancers was significantly higher than those with DCIS (6.5 vs 5.0, p =0.046). Similar results were replicated in the QuantraTM measurements, however the results were not statistically significant (17 vs 16, p = 0.19). Further analysis showed a significant positive association between whole tumour size and volumetric density for invasive lesions. Architectural distortion was the only mammographic feature associated with a significant difference in percentage density.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Boyd, N.F., Byng, J.W., Jong, R.A., Fishell, E.K., Little, L.E., Miller, A.B., Lockwood, G.A., Tritchler, D.L., Yaffe, M.J.: Quantitative classification of mammographic densities and breast cancer risk: results from the Canadian National Breast Screening Study. Journal of the National Cancer Institute 87(9), 670–675 (1995)
Kerlikowske, K., Grady, D., Barclay, J., Sickles, E.A., Ernster, V.: Effect of age, breast density, and family history on the sensitivity of first screening mammography. Jama 276(1), 33–38 (1996)
Maskarinec, G., Woolcott, C.G., Kolonel, L.N.: Mammographic density as a predictor of breast cancer outcome. Future Oncology 6(3), 351–354 (2010)
Boyd, N.F., Byng, J.W., Jong, R.A., Fishell, E.K., Little, L.E., Miller, A.B., Lockwood, G.A., Tritchler, D.L., Yaffe, M.J.: Quantitative classification of mammographic densities and breast cancer risk: results from the Canadian National Breast Screening Study. J. Natl. Cancer Inst. 87, 670–675 (1995)
http://www.hologic.com/en/breast-screening/volumetric-assessment/
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this paper
Cite this paper
Ren, K. et al. (2014). Mammographic Density and Breast Cancer Characteristics. In: Fujita, H., Hara, T., Muramatsu, C. (eds) Breast Imaging. IWDM 2014. Lecture Notes in Computer Science, vol 8539. Springer, Cham. https://doi.org/10.1007/978-3-319-07887-8_41
Download citation
DOI: https://doi.org/10.1007/978-3-319-07887-8_41
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-07886-1
Online ISBN: 978-3-319-07887-8
eBook Packages: Computer ScienceComputer Science (R0)