Skip to main content
SpringerLink
Log in

The Role of Inflammation in Head and Neck Cancer

  • Chapter
  • First Online:
Book cover Inflammation and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 816))

Abstract

Cancer-related inflammation is considered the “seventh hallmark of cancer”; numerous studies demonstrate that tumors develop and progress within inflammatory diseases. Central to the development of cancer are genetic changes that endow these cancer cells with many of the hallmarks of cancer, such as self-sufficient growth and resistance to anti-growth and pro-death signals. However, while the genetic changes that occur within cancer cells themselves, such as activated oncogenes or dysfunctional tumor suppressors, are responsible for many aspects of cancer development, they are not sufficient. Tumor promotion and progression are dependent on ancillary processes involving cells of the tumor environment that are not necessarily cancerous themselves. Infiltration of immune cells facilitates tumor development through the production of factors that promote carcinogenesis and by enabling tumors to evade the host immune response. Small molecules including cytokines, chemokines, and growth factors play key roles in both inflammation and cancer by promoting proliferation, angiogenesis, and carcinogenesis and by recruiting immune cells. The extracellular matrix is altered in inflammation and provides structural support to developing tumors. Hypoxia is a common state in cancers and inflamed tissues which causes DNA damage and induces tumorigenic factors. Finally, tissue vasculature is a vital part of its microenvironment, supplying oxygen, nutrients, and growth factors to rapidly dividing cells and providing a mechanism for metastatic spread. This review will discuss the reflexive relationship between cancer and inflammation with particular focus on how by considering the role of inflammation in physiologic processes such as the maintenance of tissue homeostasis and repair may provide a logical framework for understanding the connection between the inflammatory response and cancer. The cells and molecules outlined here represent potential targets for the treatment of head and neck cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alevizos I, Mahadevappa M, Zhang X, Ohyama H, Kohno Y, Posner M et al (2001) Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis. Oncogene 20(43):6196–6204

    CAS  PubMed  Google Scholar 

  • Allen C, Duffy S, Teknos T, Islam M, Chen Z, Albert PS et al (2007) Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma. Clin Cancer Res Off J Am Assoc Cancer Res 13(11):3182–3190

    CAS  Google Scholar 

  • Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. New Engl J Med 363(1):24–35

    CAS  PubMed Central  PubMed  Google Scholar 

  • Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357(9255):539–545

    CAS  PubMed  Google Scholar 

  • Bekes EM, Schweighofer B, Kupriyanova TA, Zajac E, Ardi VC, Quigley JP et al (2011) Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation. Am J Pathol 179(3):1455–1470

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR et al (2007) MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587–596

    CAS  PubMed  Google Scholar 

  • Bian Y, Hall B, Sun ZJ, Molinolo A, Chen W, Gutkind JS et al (2012) Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene 31(28):3322–3332

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bierie B, Stover DG, Abel TW, Chytil A, Gorska AE, Aakre M et al (2008) Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res 68(6):1809–1819

    CAS  PubMed  Google Scholar 

  • Bigbee WL, Grandis JR, Siegfried JM (2007) Multiple cytokine and growth factor serum biomarkers predict therapeutic response and survival in advanced-stage head and neck cancer patients. Clin Cancer Res Off J Am Assoc Cancer Res 13(11):3107–3108

    CAS  Google Scholar 

  • Bucala R, Donnelly SC (2007) Macrophage migration inhibitory factor: a probable link between inflammation and cancer. Immunity 26(3):281–285

    CAS  PubMed  Google Scholar 

  • Buchanan FG, Wang D, Bargiacchi F, DuBois RN (2003) Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. J Biol Chem 278(37):35451–35457

    CAS  PubMed  Google Scholar 

  • Bunt SK, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S (2006) Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J Immunol (Baltimore, Md 1950) 176(1):284–290

    Google Scholar 

  • Bunt SK, Yang L, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S (2007) Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 67(20):10019–10026

    CAS  PubMed  Google Scholar 

  • Chen Z, Malhotra PS, Thomas GR, Ondrey FG, Duffey DC, Smith CW et al (1999) Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res Off J Am Assoc Cancer Res 5(6):1369–1379

    CAS  Google Scholar 

  • Chen T, Yan W, Wells RG, Rimm DL, McNiff J, Leffell D et al (2001) Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases. Int J Cancer 93(5):653–661 (Journal international du cancer)

    CAS  PubMed  Google Scholar 

  • Chen Z, Zhang X, Li M, Wang Z, Wieand HS, Grandis JR et al (2004) Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. Clin Cancer Res Off J Am Assoc Cancer Res 10(17):5930–5939

    CAS  Google Scholar 

  • Chung CH, Gillison ML (2009) Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res Off J Am Assoc Cancer Res 15(22):6758–6762

    CAS  Google Scholar 

  • Chung JH, Rho JK, Xu X, Lee JS, Yoon HI, Lee CT et al (2011) Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs. Lung Cancer (Amst Neth) 73(2):176–182

    Google Scholar 

  • Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB et al (2004) Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. New Eng J Med 350(19):1937–1944

    PubMed  Google Scholar 

  • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867

    CAS  PubMed Central  PubMed  Google Scholar 

  • Curado MP, Hashibe M (2009) Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol 21(3):194–200

    PubMed  Google Scholar 

  • Dannenberg AJ, Subbaramaiah K (2003) Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell 4(6):431–436

    CAS  PubMed  Google Scholar 

  • De Wever O, Mareel M (2003) Role of tissue stroma in cancer cell invasion. J Pathol 200(4):429–447

    PubMed  Google Scholar 

  • Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425(6958):577–584

    CAS  PubMed  Google Scholar 

  • Dinarello CA (1996) Biologic basis for interleukin-1 in disease. Blood 87(6):2095–2147

    CAS  PubMed  Google Scholar 

  • Dohadwala M, Yang SC, Luo J, Sharma S, Batra RK, Huang M et al (2006) Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res 66(10):5338–5345

    CAS  PubMed  Google Scholar 

  • D’Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM et al (2007) Case-control study of human papillomavirus and oropharyngeal cancer. New Engl J Med 356(19):1944–1956

    PubMed  Google Scholar 

  • Dumitru CA, Gholaman H, Trellakis S, Bruderek K, Dominas N, Gu X et al (2011) Tumor-derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation. Int J Cancer 129(4):859–869 (Journal international du cancer)

    CAS  PubMed  Google Scholar 

  • Dumitru CA, Moses K, Trellakis S, Lang S, Brandau S (2012a) Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology. Cancer Immunol Immunoth (CII) 61(8):1155–1167

    CAS  Google Scholar 

  • Dumitru CA, Fechner MK, Hoffmann TK, Lang S, Brandau S (2012b) A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer. J Leukoc Biol 91(4):591–598

    CAS  PubMed  Google Scholar 

  • Dumitru CA, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S (2013) AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma. PLoS One 8(2):e56420

    CAS  PubMed Central  PubMed  Google Scholar 

  • Elwood PC, Gallagher AM, Duthie GG, Mur LA, Morgan G (2009) Aspirin, salicylates, and cancer. Lancet 373(9671):1301–1309

    CAS  PubMed  Google Scholar 

  • Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T (1999) Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res 59(14):3379–3386

    CAS  PubMed  Google Scholar 

  • Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W et al (2003) Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. New Engl J Med 349(22):2091–2098

    CAS  PubMed  Google Scholar 

  • Gasche JA, Hoffmann J, Boland CR, Goel A (2011) Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells. Int J Cancer 129(5):1053–1063

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gentil BJ, Delphin C, Mbele GO, Deloulme JC, Ferro M, Garin J et al (2001) The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B. J Biol Chem 276(26):23253–23261

    CAS  PubMed  Google Scholar 

  • Gillison ML, D’Souza G, Westra W, Sugar E, Xiao W, Begum S et al (2008) Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 100(6):407–420

    PubMed  Google Scholar 

  • Gregory AD, Houghton AM (2011) Tumor-associated neutrophils: new targets for cancer therapy. Cancer Res 71(7):2411–2416

    CAS  PubMed  Google Scholar 

  • Grieb G, Merk M, Bernhagen J, Bucala R (2010) Macrophage migration inhibitory factor (MIF): a promising biomarker. Drug News Perspect 23(4):257–264

    CAS  PubMed Central  PubMed  Google Scholar 

  • Guenin S, Mouallif M, Hubert P, Jacobs N, Krusy N, Duray A et al (2013) Interleukin-32 expression is associated with a poorer prognosis in head and neck squamous cell carcinoma. Mol Carcinog

    Google Scholar 

  • Gurova KV, Hill JE, Guo C, Prokvolit A, Burdelya LG, Samoylova E et al (2005) Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci USA 102(48):17448–17453

    CAS  PubMed Central  PubMed  Google Scholar 

  • Haase H, Podzuweit T, Lutsch G, Hohaus A, Kostka S, Lindschau C et al (1999) Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK. FASEB 13(15):2161–2172

    CAS  Google Scholar 

  • Haddad Y, Choi W, McConkey DJ (2009) Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines. Clin Cancer Res 15(2):532–542

    CAS  PubMed Central  PubMed  Google Scholar 

  • Haque MF, Meghji S, Khitab U, Harris M (2000) Oral submucous fibrosis patients have altered levels of cytokine production. J Oral Pathol Med 29(3):123–128

    CAS  PubMed  Google Scholar 

  • Hashimoto T, Gamou S, Shimizu N, Kitajima Y, Nishikawa T (1995) Regulation of translocation of the desmoyokin/AHNAK protein to the plasma membrane in keratinocytes by protein kinase C. Exp Cell Res 217(2):258–266

    CAS  PubMed  Google Scholar 

  • Heinhuis B, Koenders MI, van Riel PL, van de Loo FA, Dinarello CA, Netea MG et al (2011) Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade. Ann Rheum Dis 70(4):660–667

    CAS  PubMed  Google Scholar 

  • Henderson YC, Wang E, Clayman GL (1998) Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. Laryngoscope 108(10):1553–1556

    CAS  PubMed  Google Scholar 

  • Hirano T, Ishihara K, Hibi M (2000) Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19(21):2548–2556

    CAS  PubMed  Google Scholar 

  • Hohaus S, Massini G, Giachelia M, Vannata B, Bozzoli V, Cuccaro A et al (2010) Anemia in Hodgkin’s lymphoma: the role of interleukin-6 and hepcidin. J Clin Oncol 28(15):2538–2543

    CAS  PubMed  Google Scholar 

  • Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN (2008) Regulation of prostaglandin transporters in colorectal neoplasia. Cancer Prev Res (Philadelphia, Pa) 1(2):93–99

    CAS  Google Scholar 

  • Ichikawa A, Sugimoto Y, Negishi M (1996) Molecular aspects of the structures and functions of the prostaglandin E receptors. J Lipid Mediat Cell Signal 14(1–3):83–87

    CAS  PubMed  Google Scholar 

  • Jablonska J, Leschner S, Westphal K, Lienenklaus S, Weiss S (2010) Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest 120(4):1151–1164

    CAS  PubMed Central  PubMed  Google Scholar 

  • Jaeckel EC, Raja S, Tan J, Das SK, Dey SK, Girod DA et al (2001) Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 127(10):1253–1259

    CAS  PubMed  Google Scholar 

  • Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics, 2010. CA Cancer J Clin 60(5):277–300

    PubMed  Google Scholar 

  • Jeng JH, Wang YJ, Chiang BL, Lee PH, Chan CP, Ho YS et al (2003) Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 24(8):1301–1315

    CAS  PubMed  Google Scholar 

  • John MAS, Dohadwala M, Luo J, Wang G, Lee G, Shih H et al (2009) Proinflammatory mediators upregulate snail in head and neck squamous cell carcinoma. Clin Cancer Res 15(19):6018–6027

    Google Scholar 

  • Jones KG, Brull DJ, Brown LC, Sian M, Greenhalgh RM, Humphries SE et al (2001) Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation 103(18):2260–2265

    CAS  PubMed  Google Scholar 

  • Kang YH, Park MY, Yoon DY, Han SR, Lee CI, Ji NY et al (2012) Dysregulation of overexpressed IL-32alpha in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-kappaB and Bcl-2. Cancer Lett 318(2):226–233

    CAS  PubMed  Google Scholar 

  • Kao J, Genden EM, Chen CT, Rivera M, Tong CC, Misiukiewicz K et al (2011) Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer. Cancer 117(14):3173–3181

    CAS  PubMed  Google Scholar 

  • Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA (2005) Interleukin-32: a cytokine and inducer of TNFalpha. Immunity 22(1):131–142

    CAS  PubMed  Google Scholar 

  • Kim YY, Lee EJ, Kim YK, Kim SM, Park JY, Myoung H et al (2010) Anti-cancer effects of celecoxib in head and neck carcinoma. Mol Cells 29(2):185–194

    CAS  PubMed  Google Scholar 

  • Kim NH, Kim HS, Li XY, Lee I, Choi HS, Kang SE et al (2011) A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol 195(3):417–433

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kross KW, Heimdal JH, Aarstad HJ (2010) Mononuclear phagocytes in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol 267(3):335–344

    Google Scholar 

  • Kuang DM, Zhao Q, Wu Y, Peng C, Wang J, Xu Z et al (2011) Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol 54(5):948–955

    CAS  PubMed  Google Scholar 

  • Lee JI, Soria JC, Hassan KA, El-Naggar AK, Tang X, Liu DD et al (2001) Loss of PTEN expression as a prognostic marker for tongue cancer. Arch Otolaryngol Head Neck Surg 127(12):1441–1445

    CAS  PubMed  Google Scholar 

  • Lee TL, Yang XP, Yan B, Friedman J, Duggal P, Bagain L et al (2007) A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status. Clin Cancer Res 13(19):5680–5691

    CAS  PubMed  Google Scholar 

  • Lee TL, Yeh J, Friedman J, Yan B, Yang X, Yeh NT et al (2008) A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer 122(9):1987–1998

    CAS  PubMed  Google Scholar 

  • Lee SH, Lee SJ, Jung YS, Xu Y, Kang HS, Ha NC et al (2009) Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function. Neoplasia (NY) 11(1):22–31 (6p following)

    Google Scholar 

  • Lee J, Taneja V, Vassallo R (2012) Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res 91(2):142–149

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lin WW, Karin M (2007) A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 117(5):1175–1183

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lu SL, Herrington H, Reh D, Weber S, Bornstein S, Wang D et al (2006) Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev 20(10):1331–1342

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B et al (2013) Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res 73(6):1733–1741

    CAS  PubMed Central  PubMed  Google Scholar 

  • Massague J (2008) TGFbeta in cancer. Cell 134(2):215–230

    CAS  PubMed Central  PubMed  Google Scholar 

  • McCaul JA, Gordon KE, Clark LJ, Parkinson EK (2002) Telomerase inhibition and the future management of head-and-neck cancer. Lancet Oncol 3(5):280–288

    CAS  PubMed  Google Scholar 

  • Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS (2009) Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 45(4–5):324–334

    CAS  PubMed Central  PubMed  Google Scholar 

  • Moustakas A, Heldin CH (2009) The regulation of TGFbeta signal transduction. Dev (Cambridge, Engl) 136(22):3699–3714

    Google Scholar 

  • Nibali L, Fedele S, D’Aiuto F, Donos N (2012) Interleukin-6 in oral diseases: a review. Oral Dis 18(3):236–243

    CAS  PubMed  Google Scholar 

  • Nishimoto N (2010) Interleukin-6 as a therapeutic target in candidate inflammatory diseases. Clin Pharmacol Ther 87(4):483–487

    CAS  PubMed  Google Scholar 

  • Nozawa H, Chiu C, Hanahan D (2006) Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci USA 103(33):12493–12498

    CAS  PubMed Central  PubMed  Google Scholar 

  • Papadimitrakopoulou VA, William WN Jr, Dannenberg AJ, Lippman SM, Lee JJ, Ondrey FG et al (2008) Pilot randomized phase II study of celecoxib in oral premalignant lesions. Clin Cancer Res 14(7):2095–2101

    CAS  PubMed  Google Scholar 

  • Pasche B, Knobloch TJ, Bian Y, Liu J, Phukan S, Rosman D et al (2005) Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA 294(13):1634–1646

    CAS  PubMed  Google Scholar 

  • Pedrero JM, Carracedo DG, Pinto CM, Zapatero AH, Rodrigo JP, Nieto CS et al (2005) Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma. Int J Cancer 114(2):242–248

    CAS  PubMed  Google Scholar 

  • Perez-Ordonez B, Beauchemin M, Jordan RC (2006) Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol 59(5):445–453

    CAS  PubMed Central  PubMed  Google Scholar 

  • Piek E, Roberts AB (2001) Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis. Adv Cancer Res 83:1–54

    CAS  PubMed  Google Scholar 

  • Poeta ML, Manola J, Goldwasser MA, Forastiere A, Benoit N, Califano JA et al (2007) TP53 mutations and survival in squamous-cell carcinoma of the head and neck. New Engl J Med 357(25):2552–2561

    CAS  PubMed Central  PubMed  Google Scholar 

  • Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V et al (2007) Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. New Engl J Med 357(17):1705–1715

    CAS  PubMed  Google Scholar 

  • Reckamp K, Gitlitz B, Chen LC, Patel R, Milne G, Syto M et al (2011) Biomarker-based phase I dose-escalation, pharmacokinetic, and pharmacodynamic study of oral apricoxib in combination with erlotinib in advanced nonsmall cell lung cancer. Cancer 117(4):809–818

    CAS  PubMed  Google Scholar 

  • Reed AL, Califano J, Cairns P, Westra WH, Jones RM, Koch W et al (1996) High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 56(16):3630–3633

    CAS  PubMed  Google Scholar 

  • Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. New Engl J Med 336(14):973–979

    CAS  PubMed  Google Scholar 

  • Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR (2010) Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells. Cancer Res 70(9):3780–3790

    CAS  PubMed  Google Scholar 

  • Shao X, Tandon R, Samara G, Kanki H, Yano H, Close LG et al (1998) Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma. Int J Cancer 77(5):684–688

    CAS  PubMed  Google Scholar 

  • Shiboski CH, Schmidt BL, Jordan RC (2005) Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20–44 years. Cancer 103(9):1843–1849

    PubMed  Google Scholar 

  • Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S et al (2007) Epithelial overexpression of interleukin-32 alpha in inflammatory bowel disease. Clin Exp Immunol 149(3):480–486

    CAS  PubMed Central  PubMed  Google Scholar 

  • Shtivelman E, Cohen FE, Bishop JM (1992) A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure. Proc Natl Acad Sci USA 89(12):5472–5476

    CAS  PubMed Central  PubMed  Google Scholar 

  • St John MA, Wang G, Luo J, Dohadwala M, Hu D, Lin Y et al (2012) Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies. Br J Cancer 107(4):707–712

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sundelin K, Roberg K, Grenman R, Hakansson L (2005) Effects of cytokines on matrix metalloproteinase expression in oral squamous cell carcinoma in vitro. Acta Otolaryngol 125(7):765–773

    CAS  PubMed  Google Scholar 

  • Sussman J, Stokoe D, Ossina N, Shtivelman E (2001) Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. J Cell Biol 154(5):1019–1030

    CAS  PubMed Central  PubMed  Google Scholar 

  • Tanaka M, Jin G, Yamazaki Y, Takahara T, Takuwa M, Nakamura T (2008) Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis. Cancer Sci 99(5):979–985

    CAS  PubMed  Google Scholar 

  • Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR et al (2003) TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest 112(7):1116–1124

    CAS  PubMed Central  PubMed  Google Scholar 

  • Tergaonkar V, Perkins ND (2007) p53 and NF-kappaB crosstalk: IKKalpha tips the balance. Mol Cell 26(2):158–159

    CAS  PubMed  Google Scholar 

  • Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139(5):871–890

    CAS  PubMed  Google Scholar 

  • Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF et al (2012) Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. New Engl J Med 366(26):2443–2454

    CAS  PubMed Central  PubMed  Google Scholar 

  • Trellakis S, Bruderek K, Dumitru CA, Gholaman H, Gu X, Bankfalvi A et al (2011) Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease. Int J Cancer 129(9):2183–2193

    CAS  PubMed  Google Scholar 

  • Van Waes C (2007) Nuclear factor-kappaB in development, prevention, and therapy of cancer. Clin Cancer Res Off J Am Assoc Cancer Res 13(4):1076–1082

    Google Scholar 

  • Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M et al (2007) Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. New Engl J Med 357(17):1695–1704

    CAS  PubMed  Google Scholar 

  • Wang F, Arun P, Friedman J, Chen Z, Van Waes C (2009) Current and potential inflammation targeted therapies in head and neck cancer. Curr Opin Pharmacol 9(4):389–395

    CAS  PubMed Central  PubMed  Google Scholar 

  • Wilson JC, Anderson LA, Murray LJ, Hughes CM (2011) Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer: a systematic review. Cancer Causes Control (CCC) 22(5):803–810

    Google Scholar 

  • Wilson JC, Murray LJ, Hughes CM, Black A, Anderson LA (2013) Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer. Br J Cancer 108(5):1178–1181

    CAS  PubMed Central  PubMed  Google Scholar 

  • Worden B, Yang XP, Lee TL, Bagain L, Yeh NT, Cohen JG et al (2005) Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma. Cancer Res 65(16):7071–7080

    CAS  PubMed  Google Scholar 

  • Xie W, Bharathy S, Kim D, Haffty BG, Rimm DL, Reiss M (2003) Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: a tissue microarray analysis. Oncol Res 14(2):61–73

    CAS  PubMed  Google Scholar 

  • Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF et al (1998) IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 101(2):311–320

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zhang YE (2009) Non-Smad pathways in TGF-beta signaling. Cell Res 19(1):128–139

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zhang K, Zhaos J, Liu X, Yan B, Chen D, Gao Y et al (2011) Activation of NF-B upregulates Snail and consequent repression of E-cadherin in cholangiocarcinoma cell invasion. Hepatogastroenterology 58(105):1–7

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Head and Neck Oncology Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

    Marcelo Bonomi

  2. Head and Neck Oncology Program, Mount Sinai School of Medicine, New York, USA

    Alexis Patsias, Marshall Posner & Andrew Sikora

Authors
  1. Marcelo Bonomi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alexis Patsias
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marshall Posner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andrew Sikora
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marcelo Bonomi .

Editor information

Editors and Affiliations

  1. Dept of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bharat B. Aggarwal

  2. Dept of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bokyung Sung

  3. Dep Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Subash Chandra Gupta

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Basel

About this chapter

Cite this chapter

Bonomi, M., Patsias, A., Posner, M., Sikora, A. (2014). The Role of Inflammation in Head and Neck Cancer. In: Aggarwal, B., Sung, B., Gupta, S. (eds) Inflammation and Cancer. Advances in Experimental Medicine and Biology, vol 816. Springer, Basel. https://doi.org/10.1007/978-3-0348-0837-8_5

Download citation

Publish with us

Policies and ethics

Search

Navigation