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Biochemistry of the Lanthanides pp 339–389Cite as

Toxicology and Pharmacology of the Lanthanides

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Part of the book series: Biochemistry of the Elements ((BOTE,volume 8))

Abstract

Broadly speaking, lanthanides interfere with normal metabolism in one of two general ways. The first is through specific biochemical interaction producing, as we shall see, a variety of toxic and pharmacologic sequelae. The second concerns the damage inflicted by radioactive lanthanides. Although the latter is an important matter related to such topical concerns as the safety of nuclear power plants and the dangers of nuclear weapons, it is not, in itself, a field of inquiry that is unique to the lanthanides. Rather, it belongs to the larger arena of radiation biology and biochemistry, a discussion of which lies outside the scope of this book. For this reason, the radiotoxicity of lanthanides is not given more than a passing mention in this chapter. Instead, we shall concentrate on the metabolic and physiological perturbations produced by nonradioactive lanthanides.

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References

  • Abaas, S., 1984. Induction of aggregation in Streptococcus mit is by certain ions, Acta Pathol. Microbiol. Immunol. Scand. 92:253–259.

    CAS  Google Scholar 

  • Abel, M., and Talbot, R. B., 1967. Gadolinium oxide inhalation by guinea pigs: a correlative functional and histopathologic study, J. Pharmacol. Exp. Ther. 157:207–213.

    PubMed  CAS  Google Scholar 

  • Abramczuk, J. W., 1985. The effects of lanthanum chloride on pregnancy in mice and on preimplantation mouse embryos in vitro, Toxicology 34:315–320.

    PubMed  CAS  Google Scholar 

  • Ajazzi-Mancini, M., 1926. Cited in Haley (1965).

    Google Scholar 

  • Anon, 1988. RE in fresh-water fishery, China Rare Earth Info. 9:3.

    Google Scholar 

  • Arkhangelskaya, L.N., and Spasskii, S.S., 1967. Cited in Haley (1979).

    Google Scholar 

  • Arvela, P., 1973. The in vitro effects of lanthanons on lipid peroxidation and drug metabolism in rat, Acta Physiol. Scand. Suppl. 396:234.

    Google Scholar 

  • Arvela, P., 1974. The effect of α-tocopherol on cerium induced changes in drug and lipid metabolism of rat, Experientia 30:1061–1062.

    PubMed  CAS  Google Scholar 

  • Arvela, P., 1979. Toxicity of rare-earths, Prog. Pharmacol. 2:71–114.

    Google Scholar 

  • Arvela, P., and Karki, N.T., 1971. Effect of cerium on drug metabolizing activity in rat liver, Experientia 27:1189–1190.

    PubMed  CAS  Google Scholar 

  • Arvela, P., and Karki, N.T., 1972. Effect of phenobarbital pretreatment on cerium induced impairment of drug metabolism in rat liver, Acta Pharmacol. Toxicol. 31:380–386.

    CAS  Google Scholar 

  • Arvela, P., Grajewski, O., Von Lehmann, B., and Oberdisse, E., 1977. Effect of lanthanons on substrate-induced difference spectra in rat liver microsomes, Experientia 32:491–493.

    Google Scholar 

  • Arvela, P., Von Lehmann, B., Grajewski, O., and Oberdisse, E., 1980a. Effect of praseodymium on drug metabolism in rat liver smooth and rough endoplasmic reticulum, Experientia 36:860–861.

    PubMed  CAS  Google Scholar 

  • Arvela, P., Oberdisse, E., Merker, H. J., Grajewski, O., and Von Lehmann, B., 1980b. The influence of lanthanons on morphology and function of rat exocrine pancreas in vivo, Pathol. Res. Pract. 169:330–340.

    PubMed  CAS  Google Scholar 

  • Arvela, P., Reinila, M., and Pelkonen, O., 1981. Effects of phenobarbital and β-naphtho- flavone on cerium induced biochemical changes in rat serum, Toxicol. Lett. 8:213–216.

    PubMed  CAS  Google Scholar 

  • Baehr, G., and Wessler, H., 1909. The use of cerium oxalate for the relief of vomiting: an experimental study of the effects of some salts of cerium, lanthanum, praseodymium, neodymium and thorium, Arch. Intern. Med. 2:517–531.

    Google Scholar 

  • Bahadur, K., and Tripathi, P., 1978. Investigation of cerium and yttrium ions’ effects on microbial nitrogen fixation and determination of inhibition, Zentralbl. Bakteriol. II Abt. 133:628–631.

    CAS  Google Scholar 

  • Bahadur, K., Prakash, S., and Jyotishmati, U., 1978. Microbial fixation of nitrogen in presence of lanthanum sulphate with sodium molybdate, Zentralbl. Bakteriol. II Abt. 133:632–637.

    CAS  Google Scholar 

  • Ball, R. A., and Van Gelder, G., 1966. Chronic toxicity of gadolinium oxide for mice following exposure by inhalation, Arch. Environ. Health 13:601–608.

    PubMed  CAS  Google Scholar 

  • Ball, R.A., Van Gelder, G., and Green, J.W., 1970. Neoplastic sequelae following subcutaneous implantation of mice with rare earth metals, Proc. Soc. Exp. Biol. Med. 135: 426–430.

    PubMed  CAS  Google Scholar 

  • Basu, A., Haldar, S., Chakrabarty, K., Santra, M., and Chatterje, G.C., 1984. Effect of cysteine supplementation on lanthanum chloride induced alterations in the antioxidant defense system of chick liver, Indian J. Exp. Biol. 22:432–434.

    PubMed  CAS  Google Scholar 

  • Beaser, S.B., Segel, A., and Vandam, L., 1942. The anticoagulant effects in rabbits and man of the intravenous injection of salts of the rare earths, J. Clin. Invest. 21:447–453.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Beller, F. K., and Mammen, E., 1956. Der angriffspunkt der seltenen erden neodym in Gerinnungssystem, Arch. Gynaek. 187:319–336.

    CAS  Google Scholar 

  • Bjondahl, K., Mottonen, M., and Nieminen, L., 1973. The effect of spironolactone on acute toxicity and liver damage in mice induced by cerium chloride, Experientia 29:685–687.

    PubMed  CAS  Google Scholar 

  • Bjondahl, K., Isomaa, B., and Nieminen, L., 1974. Effect of pretreatment with phenobarbital and spironolactone on 144Ce levels in blood, liver, urine and faeces at various time periods, Biochem. Pharmacol. 23:1509–1518.

    PubMed  CAS  Google Scholar 

  • Bjorkman, S.E., and Horsfall, F.L., 1948. The production of a persistent alteration in influenza virus by lanthanum or ultraviolet irradiation, J. Exp. Med. 88:445–461.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Borowitz, J. L., 1972. Effect of lanthanum on catecholamine release from adrenal medulla, Life Sci. 11:959–964.

    CAS  Google Scholar 

  • Boyd, K. S., Melnykovych, G., and Fiskin, A. M., 1976. A replica technique for visualizing the distribution of lanthanum-binding sites over HeLa surfaces, Cytobiology 14:91–101.

    CAS  Google Scholar 

  • Brooks, M.M., 1921. Comparative studies on respiration. XIV. Antagonistic action of lanthanum as related to respiration, J. Gen. Physiol. 3:337–342.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Bruce, D. W., Hietbrink, B. E., and DuBois, K. P., 1963. The acute mammalian toxicity of rare earth nitrates and oxides, Toxicol. Appl. Pharmacol. 5:750–759.

    PubMed  CAS  Google Scholar 

  • Bulman, R. A., and Stretton, R. J., 1975. Effect of the lanthanides lanthanum and neodymium on the heat resistance of Bacillus cereus spores, Microbios 12:167–174.

    PubMed  CAS  Google Scholar 

  • Burkes, S., and McCleskey, C.S., 1947. The bacteriostatic activity of cerium, lanthanum and thallium, J. Bacteriol. 54:417–424.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Burnett, K.R., Wolf, G.L., Schumacher, H.R., and Goldstein, E.J., 1985. Gadolinium oxide: a prototype agent for contrast enhanced imaging of the liver and spleen with magnetic resonance, Magn. Reson. Imaging 3:65–71.

    PubMed  CAS  Google Scholar 

  • Caillé, J. M., Lemanceau, B., and Bonnemari, B., 1983. Gadolinium as a contrast agent for NMR, Am. J. Nucl. Med. 4:1041–1042.

    Google Scholar 

  • Cassone, A., and Garaci, E., 1974. Lanthanum staining of the intermediate region of the cell wall in Escherichia coli, Experientia 30:1230–1232.

    CAS  Google Scholar 

  • Castillo, M.R., and Bibby, B.G., 1973. Trace element effects on enamel pigmentation, incisor growth and molar morphology in rats, Arch. Oral Biol. 18:629–635.

    Google Scholar 

  • Cochran, K. W., Doull, J., Mazur, M., and DuBois, K. P., 1950. Acute toxicity of zirconium, columbium, strontium, lanthanum, cesium, tantalum and yttrium, Arch. Ind. Hyg. Occup. Med. 1:637–650.

    PubMed  CAS  Google Scholar 

  • D’Agostino, R. B., Lown, B.A., Morganti, J.B., and Massaro, E.J., 1982. Effects of in utero or suckling exposure to cerium (citrate) on the postnatal development of the mouse, J. Toxicol. Environ. Health 1:449–458.

    Google Scholar 

  • Davison, F.C., and Ramsey, F. K., 1965. Cited in Haley (1979).

    Google Scholar 

  • Dorovini-Zis, K., Sato, M., Goping, G., Rapoport, S., and Brightman, M., 1983. Ionic lanthanum passage across cerebral endothelium exposed to hyperosmotic arabinose, Acta Neuropathol. 60:49–60.

    PubMed  CAS  Google Scholar 

  • Drossbach, G. P., 1897. Über den Einfluss der Elemente der Cerund Zircon gruppe auf das Wachstum von Bakterien, Zentralbl. Bakteriol. Parasitenkd. Abt. 1 Orig. 21:57–58.

    Google Scholar 

  • Drouven, B. J., and Evans, C. H., 1986. Collagen fibrillogenesis in the presence of lanthanides, J. Biol. Chem. 261:11792–11797.

    PubMed  CAS  Google Scholar 

  • Dryfuss, B.J., and Wolf, C.G.L., 1906. The physiological action of lanthanum, praseodymium and neodymium, Am. J. Physiol. 16:314–323.

    CAS  Google Scholar 

  • Ecker, D. J., Butt, T. R., Sternberg, E. J., Neeper, M.P., Debouck, C., Gorman, J. A., and Crooke, S. T., 1986. Yeast metallothionein function in metal ion detoxification, J. Biol. Chem. 261:16895–16900.

    PubMed  CAS  Google Scholar 

  • Eisenberg, P., 1919. Untersuchungen über spezifische Desinfektionsvorgange. II. Über die Wirkung von Salzen und Ionen auf Bakterien, Zentralbl. Bakteriol. Parasitenkd. Abt. 1 Orig. 82:69–208.

    Google Scholar 

  • Evans, W. H., 1913. The influence of the carbonates of the rare earths (cerium, lanthanum, yttrium) on growth and cell-division in hyacinths, Biochem. J. 7:349–355.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ewaldsson, E., and Magnusson, G., 1964a. Distribution of radiocerium and radiopromethium in mice, Acta Radiol. Ther. Phys. Biol. 2:65–72.

    PubMed  CAS  Google Scholar 

  • Ewaldsson, E., and Magnusson, G., 1964b. Distribution of radioterbium, radioholmium and radioyttrium in mice, Acta Radiol. Ther. Phys. Biol. 2:121–128.

    PubMed  CAS  Google Scholar 

  • Farkas, B., and Karacsonyi, G., 1985. The effect of ketoconazole on Candida albicans infection following depression of the reticuloendothelial activity with gadolinium chloride, Mykosen 28:338–341.

    PubMed  CAS  Google Scholar 

  • Fischler, F., and Roeckl, K. W., 1938. Über experimentelle Beeinflussung er Leberfunktionen und der anatomischen Leberstruktur durch Einwirkung seltaer Erden, Naunyn-Schmiedeberg’s Arch. Exp. Pathol. Pharmacol. 189:4–21.

    CAS  Google Scholar 

  • Fleisch, H., and Neuman, W. F., 1961. Mechanisms of calcification: role of collagen, polyphosphates and phosphatase, Am. J. Physiol. 200:1296–1300.

    CAS  Google Scholar 

  • Gabbiani, G., and Tuchweber, B., 1965. Studies on the mechanism of experimental soft tissue calcification, Can. J. Physiol. Pharmacol. 43:177–183.

    PubMed  CAS  Google Scholar 

  • Gabbiani, G., and Tuchweber, B., 1970. Studies on the mechanism of calcergy, Clin. Orthop. 69:66–74.

    PubMed  CAS  Google Scholar 

  • Gabbiani, G., Jacqmin, M.L., and Richard, R. M., 1966. Soft-tissue calcification induced by rare earth metals and its prevention by sodium pyrophosphate, Br. J. Pharmacol. 27:1–9.

    CAS  Google Scholar 

  • Gale, T. F., 1975. The embryotoxicity of ytterbium chloride in golden hamsters, Teratology 11:289–296.

    PubMed  CAS  Google Scholar 

  • Garrett, I. R., and McClure, J., 1981. Lanthanide-induced calcergy, J. Pathol. 135:267–275.

    PubMed  CAS  Google Scholar 

  • Gehrcke, E., Lau, E., and Meinhart, O., 1939. The rare earths and the nervous system, Z. Ges. Naturwiss. 5:106–107.

    CAS  Google Scholar 

  • Gerhardsson, L., Wester, P.O., Nordberg, G. F., and Brune, D., 1984. Chromium cobalt and lanthanum in lung, liver and kidney tissue from deceased smelter workers, Sci. Total Environ. 37:233–246.

    PubMed  CAS  Google Scholar 

  • Glenn, J. L., Tischer, K., and Stein, A., 1962. Rare-earth fatty liver. I. Octanoate oxidation and energy production, Biochim. Biophys. Acta 62:35–40.

    PubMed  CAS  Google Scholar 

  • Godin, D. V., and Frohlich, J., 1981. Erythrocyte alterations in praseodymium-induced lecithin:cholesterol acyltransferase (LCAT) deficiency in the rat: comparison with familial LCAT deficiency in man, Res. Commun. Chem. Pathol. Pharmacol. 31:555–556.

    PubMed  CAS  Google Scholar 

  • Graca, J.G., Garst, E.L., and Lowry, W. E., 1957. Comparative toxicity studies of stable rare earth compounds. I. Effect of citrate complexing on stable rare earth chloride toxicity, A.M.A. Arch. Ind. Health 15:9–14.

    Google Scholar 

  • Graca, J.G., Davison, F. C., and Feavel, J.B., 1962. Comparative toxicity of stable rare earth compounds. II. Effect of citrate and edetate complexing on acute toxicity in mice and guinea pigs, Arch. Environ. Health 5:437–444.

    PubMed  CAS  Google Scholar 

  • Graca, J.G., Davison, F. C., and Feavel, J. B., 1964. Comparative toxicity of stable rare earth compounds. III. Acute toxicity of intravenous injections of chlorides and chelates in dogs, Arch. Environ. Health 8:555–564.

    PubMed  CAS  Google Scholar 

  • Grajewski, O., Von Lehmann, B., Arntz, H.R., Arvela, P., and Oberdisse, E., 1977. Alterations in rat serum lipoproteins and lecithin-cholesterol-acyltransferase activity in praseodymium-induced liver damage, Naunyn-Schmiedeberg’s Arch. Pharmacol. 301: 65–73.

    CAS  Google Scholar 

  • Grant, W.M., and Kern, H.L., 1956. Cations and the cornea. Toxicity of metals to the stroma, Am. J. Ophthalmol. 42:167–181.

    PubMed  CAS  Google Scholar 

  • Graul, E. H., and Hundeshagen, H., 1959. Investigations of radioyttrium (Y90) metabolism. Studies on organ-distribution with special regard to the radioautographic method of demonstration and to paper electrophoresis under various experimental conditions, Int. J. Appl. Radiat. Isotop. 5:243–252.

    CAS  Google Scholar 

  • Guida, G., 1930. Cited in Haley (1965).

    Google Scholar 

  • Guo, B., 1985. Present and future of rare earth research in Chinese agriculture, J. Chin. Rare Earth Soc. 3:89–94.

    CAS  Google Scholar 

  • Haley, T. J., 1965. Pharmacology and toxicology of the rare earth elements, J. Pharm. Sci. 54:663–670.

    PubMed  CAS  Google Scholar 

  • Haley, T. J., 1979. Toxicity, in Handbook on the Physics and Chemistry of Rare Earths (K. A. Gschneidner and L. R. Eyring, eds.), Vol. 4, North-Holland, Amsterdam, pp. 553–585.

    Google Scholar 

  • Haley, T. J., and Upham, H.C., 1963. Skin reaction to intradermal injection of rare earths, Nature 200:271.

    PubMed  CAS  Google Scholar 

  • Haley, T. J., Raymond, K., Komesu, N., and Upham, H.C., 1961. Toxicological and pharmacological effects of gadolinium and samarium chlorides, Br. J. Pharmacol. 17:526–532.

    CAS  Google Scholar 

  • Haley, T.J., Komesu, N., Flesher, A.M., Mavis, L., Cawthorne, J., and Upham, H.C., 1963. Pharmacology and toxicology of terbium, thulium and ytterbium chlorides, Toxicol. Appl. Pharmacol. 5:427–436.

    PubMed  CAS  Google Scholar 

  • Haley, T.J., Komesu, N., Efros, M., Koste, L., and Upham, H.C., 1964. Pharmacology and toxicology of lutetium chloride, J. Pharm. Sci. 53:1186–1188.

    PubMed  CAS  Google Scholar 

  • Hara, S., 1923. Beitrage zur Pharmakologie der Seltenen Erdmetalle. I. Mitteilung: Über das cerium, Naunyn-Schmiedeberg’s Arch. Exp. Pathol. Pharmacol. 100:217–253.

    CAS  Google Scholar 

  • Harris, R.A., Iwamoto, E.T., Loh, H.H., and Way, E.L., 1975. Analgetic effects of lanthanum: cross-tolerance with morphine, Brain Res. 100:221–225.

    PubMed  CAS  Google Scholar 

  • Harris, R. A., Loh, H. H., and Way, E. L., 1976. Antinociceptive effects of lanthanum and cerium in nontolerant and morphine tolerant-dependent animals, J. Pharmacol. Exp. Ther. 196:288–297.

    PubMed  CAS  Google Scholar 

  • Havron, A., Davis, M.A., Seller, S.E., Paskins-Hurlburt, A. J., and Hessel, S.J., 1980. Heavy metal particulate contrast materials for computed tomography of the liver, J. Comput. Assist. Tomogr. 4:642–648.

    PubMed  CAS  Google Scholar 

  • Heuck, F., and Hoschek, R., 1968. Cer-pneumoconiosis, Am. J. Radiol. 104:777–783.

    CAS  Google Scholar 

  • Hunter, R. B., and Walker, W., 1956. Anticoagulant action of neodymium 3-sulfo-isonicotinate, Nature 178:47.

    PubMed  CAS  Google Scholar 

  • Husain, M.H., Dick, J. A., and Kaplan, Y.S., 1980. Rare earth pneumoconiosis, J. Soc. Occup. Med. 30:15–19.

    PubMed  CAS  Google Scholar 

  • Husztik, E., Lazar, G., and Parducz, A., 1980. Electron microscopic study of Kupffer-cell phagocytosis blockage induced by gadolinium chloride, Br. J. Exp. Pathol. 61:624–630.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Hutcheson, D. P., Gray, D. H., Verugopal, B., and Luckey, T. D., 1975. Nutritional safety of heavy metals in mice, J. Nutr. 105:670–675.

    PubMed  CAS  Google Scholar 

  • Iwamoto, E. T., Harris, R. A., Loh, H. H., and Way, E. L., 1978. Antinociceptive responses after microinjection of morphine or lanthanum in discrete rat brain sites, J. Pharmacol. Exp. Ther. 206:46–55.

    PubMed  CAS  Google Scholar 

  • Johansson, O., Perrault, G., Savoie, L., and Tuchweber, B., 1968. Action of various metallic chlorides on calcaemia and phosphataemia, Br. J. Pharmacol. Chemother. 33:91–97.

    Google Scholar 

  • Kadas, I., Tanka, D., Keller, M., and Jobst, K., 1974a. Enzyme-histochemical and biochemical study of liver injury induced by lanthanum trichloride, Acta Morphol. Acad. Sci. Hung. 22:35–45.

    PubMed  CAS  Google Scholar 

  • Kadas, I., Lapis, K., and Jobst, K., 1974b. Electron microscopic studies of liver changes induced by lanthanum trichloride, Acta Morphol. Acad. Sci. Hung. 22:343–357.

    PubMed  CAS  Google Scholar 

  • Keresztes-Nagy, P., and Rosenfeld, J.P., 1981. Naloxone-reversible duplication by lanthanum of differential opiate analgesic effects on orofacial versus lower body versus central nociception, Brain Res. 208:234–239.

    PubMed  CAS  Google Scholar 

  • Kikhachev, Yu. P., Lyarskii, P.P., and Elovskaya, L.T., 1972. Cited in Haley (1979).

    Google Scholar 

  • Kyker, G.C., and Cress, E. A., 1957. Acute toxicity of yttrium, lanthanum and other rare earths, A.M.A. Arch. Ind. Health 16:475–479.

    CAS  Google Scholar 

  • Kyker, G. C., Cress, E. A., Sivaramakrishnan, V. M., Steffee, C. H., and Stewart, M., 1957. Fatty infiltration due to rare earths, Fed. Proc. 16:207.

    Google Scholar 

  • Laszlo, D., Ekstein, D. M., Lewin, R., and Stern, K. G., 1952. Biological studies on stable and radioactive rare earth compounds. I. On the distribution of lanthanum in the mammalian organism, J. Natl. Cancer Inst. 13:559–573.

    PubMed  CAS  Google Scholar 

  • Lazar, G., 1973a. Effect of reticuloendothelial stimulation and depression on rare earth metal chloride-induced splenic calcification and fatty degeneration of the liver, Exper-ientia 29:818–819.

    CAS  Google Scholar 

  • Lazar, G., 1973b. The reticuloendothelial-blocking effect of rare earth metals in rats, J. Reticuloendothel. Soc. 13:231–237.

    PubMed  CAS  Google Scholar 

  • Lazar, G., Husztik, E., and Ribarszki, S., 1985. Reticuloendothelial blockade induced by gadolinium chloride. Effect on humoral immune response and anaphylaxis, in Macrophage Biology (S. Reichard and M. Kojima, eds.), Alan Liss, New York, pp. 571–582.

    Google Scholar 

  • Lombardi, B., and Recknagel, R.O., 1962. Interference with secretion of triglycerides by the liver as a common factor in toxic liver injury, Am. J. Pathol. 40:571–586.

    PubMed Central  PubMed  CAS  Google Scholar 

  • MacDonald, N. W., Nusbaum, R. E., Alexander, G. V., Ezmirnan, F., Spain, P., and Rounds, D.E., 1952. The skeletal deposition of yttrium, J. Biol. Chem. 195:837–842.

    PubMed  CAS  Google Scholar 

  • Magnusson, G., 1963. The behavior of certain lanthanons in rats, Acta Pharmacol. Toxicol., Suppl. 3 20:1–95.

    Google Scholar 

  • Marciniak, M., and Baltrukiewicz, Z., 1977. Serum ornithine carbonoyltransferase (OCT) in rats poisoned with lanthanum, cerium and praseodymium, Acta Physiol. Pol. 28: 589–594.

    PubMed  CAS  Google Scholar 

  • Maxwell, L. C., Bischoff, F., and Ottery, E. M., 1931. Studies in cancer chemotherapy. X. The effect of thorium, cerium, erbium, yttrium, didymium, praseodymium, manganese and lead upon transplantable rat tumors, J. Pharmacol. Exp. Ther. 43:61–70.

    CAS  Google Scholar 

  • McClure, J., 1980. The production of heterotropic calcification by certain chemical salts, J. Pathol. 131:21–33.

    PubMed  CAS  Google Scholar 

  • Mezentseva, N. V., 1967. Cited in Haley (1979).

    Google Scholar 

  • Miller, L. P., 1959. Factors influencing the uptake and toxicity of fungicides, Trans. N.Y. Acad. Sci. 21:442–445.

    CAS  Google Scholar 

  • Miller, L.P., and McCallan, S.E. A., 1957. Toxic action of metal ions to fungus spores, J. Agrie. Food Chem. 5:116–122.

    CAS  Google Scholar 

  • Mogilevskaya, O. Ya., and Roshchina, T. A., 1967. Cited in Haley (1979).

    Google Scholar 

  • Morganti, J. B., Lown, B. A., Chapín, E., D’Agostino, R. B., and Monteverde, E. J., 1980. Effects of acute exposure to cerium nitrate on selected measures of activity, learning and social behavior of the mouse, Gen. Pharmacol. 11:369–373.

    PubMed  CAS  Google Scholar 

  • Mori, I., 1931. Pharmakologische Untersuchungen über die seltenen Erdmetaila Lanthan, Cerium, Praseodym und Neodym, Jpn. J. Med. Sci. 5:13–14.

    Google Scholar 

  • Muroma, A., 1958. Studies on the bactericidal action of salts of certain rare earth metals, Ann. Med. Exp. Biol. Fenn. 36(Suppl. 6): 1–54.

    PubMed  CAS  Google Scholar 

  • Muroma, A., 1959. The bactericidal action of the rare earth metals (further studies), Ann. Med. Exp. Biol. Fenn. 37(Suppl. l-7):336–340.

    PubMed  CAS  Google Scholar 

  • Nagy, I., Kadas, I., and Jobst, K., 1976. Lanthanum trichloride induced blood coagulation defect and liver injury, Haematologia 10:353–359.

    PubMed  CAS  Google Scholar 

  • Nappee, J., Bobrie, J., and Lombard, D., 1972. Pneumoconiosis au cérium, Arch. Mal. Prof. Med. Trav. Sec. Soc. 33:13–18.

    CAS  Google Scholar 

  • Neubert, D., and Hoffmeister, I., 1960. Intracellular Lokalisation von Fettsubstanzen bei experimenteller Leberverfettong, Nannyn-Schmiedeberg’s Arch. Exp. Pathol. Pharmacol. 237:519–537.

    CAS  Google Scholar 

  • Niccolini, P. M., 1930. Contributo allo studio farmacologico delle terre rare—il praseodimio, Arch. Int. Pharmacodyn. Ther. 37:199–240.

    Google Scholar 

  • Niccolini, P.M., 1931. Contributo allo studio farmacologico delle terre rare—il samario, Arch. Int. Pharmacodyn. Ther. 40:247–291.

    Google Scholar 

  • Novello, F., and Stirpe, F., 1969. The effects of copper and other ions on the ribonucleic acid polymerase activity of rat liver nuclei, Biochem. J. 111:115–119.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Oberdisse, E., Rohling, G., Losert, W., Schurig, R., and Oberdisse, U., 1973. Influence of rare earths on insulin secretion in rats, Naunyn-Schmiedeberg’s Arch. Pharmacol. 280: 217–221.

    CAS  Google Scholar 

  • Oberdisse, E., Winkler, R., Grajewski, O., Von Lehmann, B., and Arntz, H.R., 1974. Pharmakologische Untersuchungen zum Mechanismus der Praseodym—ausgelosten Leberschadigung, Verh. Dtsch. Ges. Inn. Med. 80:1556–1558.

    PubMed  CAS  Google Scholar 

  • Oberdisse, E., Arvela, P., and Gross, U., 1979. Lanthanon-induced hepatotoxicity and its prevention by pretreatment with the same lanthanon, Arch. Toxicol. 43:105–114.

    PubMed  CAS  Google Scholar 

  • Oga, S., 1971. Actividade teratogenica do cloreto de iterbioem embrião de galinha, Rev. Farm. Bioquim. Univ. São Paulo 9:327–341.

    PubMed  CAS  Google Scholar 

  • Ojemann, R.G., Brownell, G.I., and Sweet, W.H., 1961. Possible radiation therapy of cephalic neoplasms by perfusion of short-lived isotopes. II. Dysprosium-165 metabolism in mouse and cat, Neurochirurgica 4:41–57.

    Google Scholar 

  • Palmer, R. J., Buterhoff, J. L., and Stevens, J. B., 1987. Cytotoxicity of the rare earth metals cerium, lanthanum, and neodymium in vitro: comparisons with cadmium in a pulmonary macrophage primary culture system, Environ. Res. 43:142–156.

    PubMed  CAS  Google Scholar 

  • Pederson, L. A., and Libby, W. F., 1972. Unseparated rare earth-cobalt oxides as auto exhaust catalysts, Science 176:1355–1356.

    Google Scholar 

  • Pickard, B.G., 1970. Comparison of calcium and lanthanum ions in the Avena-coleoptile growth test, Planta 90:314–320.

    Google Scholar 

  • Ranganayaki, S., Bahadur, K., and Mohan, C., 1981. Microbial fixation of nitrogen in the presence of lanthanum sulphate, Z. All. Mik. 21:329–332.

    CAS  Google Scholar 

  • Rapaport, M.J., 1982. Depigmentation with cerium oxide, Contact Dermatitis 8:282–283.

    PubMed  CAS  Google Scholar 

  • Reddy, S. V. R., and Yaksh, T. L., 1980. Antinociceptive effects of lanthanum, neodymium and europium following intrathecal administration, Neuropharmacology 19:181–185.

    PubMed  CAS  Google Scholar 

  • Renaud, G., Soler-Argilaga, C., and Infante, R., 1980a. Effect of cerium on liver lipids metabolism and plasma lipoproteins synthesis in the rat, Biochem. Biophys. Res. Commun. 95:220–227.

    PubMed  CAS  Google Scholar 

  • Renaud, G., Soler-Argilaga, C., Rey, C., and Infante, R., 1980b. Free fatty acid mobilization in the development of cerium-induced fatty liver, Biochem. Biophys. Res. Commun. 92:374–380.

    PubMed  CAS  Google Scholar 

  • Robinson, G. A., Wasnidge, D.C., and Floto, F., 1978. Distribution of 140La and 47Ca in female Japanese quail and in the eggs laid, Poultry Sci. 57:190–196.

    CAS  Google Scholar 

  • Robinson, G. A., Wasnidge, D.C., and Floto, F., 1980. Radiolanthanides as markers for vitellogenin-derived proteins in the growing oocytes of Japanese quail, Poultry Sci. 59: 2312–2321.

    CAS  Google Scholar 

  • Rohling, G., 1974. Enfluss von Praseodym auf den Kohlenhydratstoffwechsel und die Insulinsekretion, Thesis, Freie Universität Berlin, cited in Arvela (1979).

    Google Scholar 

  • Rosenfeld, J. P., and Hammer, M., 1983. Antagonism of opiate-like, lanthanum-induced analgesia by naloxone, 12 mg/kg, in rats, Brain Res. 268:189–191.

    PubMed  CAS  Google Scholar 

  • Saffer, L.D., Rodeheaver, G.T., Hiebert, J.M., and Edlick, R.F., 1980. In vivo and in vitro antimicrobial activity of silver sulfadiazine and cerium nitrate, Surg. Gynecol. Obstet. 151:232–236.

    PubMed  CAS  Google Scholar 

  • Salas, M., and Tuchweber, B., 1976. Prevention by steroids of cerium hepatotoxicity, Arch. Toxicol. 35:115–125.

    PubMed  CAS  Google Scholar 

  • Salas, M., Tuchweber, B., Kovacs, K., and Garg, B. D., 1976. Effect of cerium on the rat liver. An ultrastructural and biochemical study, Beitr. Pathol. Biol. 157:23–44.

    CAS  Google Scholar 

  • Sanna, A., Mascia, A., Pani, P., and Congiu, L., 1976. Protection by cerium chloride on CCl4-induced hepatotoxicity, Experientia 32:91–92.

    PubMed  CAS  Google Scholar 

  • Santos, M.C., Azevedo, M. D., and Jacobsohn, K., 1982. Effect of Eu3+ on lipid biosynthesis in rat liver, Biochimie 64:305–308.

    PubMed  CAS  Google Scholar 

  • Sarkadi, B., Szasz, I., Gerloczy, A., and Grardos, G., 1977. Transport parameters and stoichiometry of active calcium ion extrusion in intact human red cells, Biochim. Biophys. Acta 464:93–107.

    PubMed  CAS  Google Scholar 

  • Sarkander, H.I., and Brade, W.P., 1976. On the mechanism of lanthanide-induced liver toxicity, Arch. Toxicol. 36:1–17.

    PubMed  CAS  Google Scholar 

  • Sarnat, A. E., 1983. The efficiency of cobalt samarium (Co 5 Sm) magnets as retention units for overdentures, J. Dent. 11:324–333.

    PubMed  CAS  Google Scholar 

  • Sartory, A., and Bailly, P., 1922. Influence des sels de terres rares sur la structure du mycélium de l’Aspergillus fumigatus Fr. et sur la formation de l’appareil conidier, C. R. Soc. Biol. 86:601–604.

    Google Scholar 

  • Schepers, G.W. H., 1955a. The biological action of rare earths: I. The experimental pulmonary histopathology produced by a blend having a relatively high oxide content, A.M.A. Arch. Ind. Health 12:301–305.

    CAS  Google Scholar 

  • Schepers, G. W. H., 1955b. The biological action of rare earths: II. The experimental pulmonary histopathology produced by a blend having a relatively high fluoride content, A.M.A. Arch. Ind. Health 12:306–316.

    CAS  Google Scholar 

  • Schepers, G. W. H., Delahart, A. B., and Redlin, A. J., 1955. An experimental study of the effects of rare earths on animal lungs, Arch. Ind. Health 12:297–316.

    CAS  Google Scholar 

  • Schimmel, R. J., 1978. Calcium antagonists and lipolysis in isolated rat epididymal adipocytes: effects of tetracaine, manganese, cobaltous and lanthanum ions and D600, Horm. Metab. Res. 10:128–134.

    PubMed  CAS  Google Scholar 

  • Schmantz, E., 1964. Geschlechtsabhangigkeit der Verteilung von Radiocer kei der Ratte, Strahlentherapie 123:267–278.

    Google Scholar 

  • Schorderet-Slatkine, S., Schorderet, M., and Bailieu, E.-E., 1976. Initiation of meiotic maturation in Xenopus laevis oocytes by lanthanum, Nature 262:289.

    PubMed  CAS  Google Scholar 

  • Schroeder, H.A., and Mitchener, M., 1971. Scandium, chromium(VI), gallium, yttrium, rhodium, palladium, indium in mice: effects on growth and lifespan, J. Nutr. 101: 1431–1438.

    PubMed  CAS  Google Scholar 

  • Schurig, R., and Oberdisse, E., 1972. The influence of rare earths on hepatic gluconeogen-esis, Naunyn-Schmiedeberg’s Arch. Pharmacol. 275:419–433.

    CAS  Google Scholar 

  • Sedmak, J. J., MacDonald, H.S., and Kushnaryov, V.M., 1986. Lanthanide ion enhancement of interferon binding to cells, Biochem. Biophys. Res. Commum. 137:480–485.

    CAS  Google Scholar 

  • Seltzer, S. E., Adams, D. F., Davis, M. A., Hessel, S. J., Hevron, A., Judy, P. F., Hurlburt, A. J., and Hollenbert, N. K., 1981. Hepatic contrast agents for CT: high atomic number contrast material, J. Comput. Assist. Tomogr. 5:370–374.

    PubMed  CAS  Google Scholar 

  • Selye, H., 1962. Calciphylaxis, University of Chicago Press, Chicago, p. 311.

    Google Scholar 

  • Selye, H., Szabo, S., Tuchweber, B., and Lefebvre, F., 1972. Acute miliary necrosis resembling reliosis hepatis produced by the combination of glucocorticoid and gadolinium, Proc. Soc. Exp. Biol. Med. 139:887–889.

    PubMed  CAS  Google Scholar 

  • Sharma, S.N., Chatterjee, S.M., and Kamboj, V.P., 1973. Sterilization of male goats by formaldehyde and some metallic salts, Indian J. Exp. Biol. 11:143–148.

    PubMed  CAS  Google Scholar 

  • Shearer, C., 1922. Studies of the action of electrolytes on bacteria, J. Hyg. 21:77–86.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Shelley, W.B., Hurley, H.J., Mayock, R.L., Close, H.P., and Cathcart, R.T., 1958. Intradermal tests with metals and other inorganic elements in saracoidosis and anthraco-silicosis, J. Invest. Dermatol. 31:301–303.

    PubMed  CAS  Google Scholar 

  • Sievers, R.E., and Sadlowski, J.E., 1978. Volatile metal complexes. Certain chelates are useful as fuel additives, as metal vapor sources and in trace metal analysis, Science 201:217–223.

    PubMed  CAS  Google Scholar 

  • Sihvonen, M. L., 1972. Accumulation of yttrium and lanthanoids in human and rat tissues as shown by mass spectrometric analysis and some experiments with rats, Ann. Acad. Sci. Fenn. Ser. A 168:1–62.

    Google Scholar 

  • Smith, B. M., Gindhart, T. D., and Colburn, N. H., 1986. Possible involvement of a lanthanide-sensitive protein kinase C substrate in lanthanide promotion of neoplastic transformation, Carcinogenesis 7:1949–1956.

    PubMed  CAS  Google Scholar 

  • Snyder, F., and Kyker, G. C., 1964. Triglyceride accumulation and release in the rare-earth fatty liver, Proc. Soc. Exp. Biol. Med. 116:890–893.

    PubMed  CAS  Google Scholar 

  • Snyder, F., and Stephens, N., 1961. Plasma free fatty acids and the rare-earth fatty liver, Proc. Soc. Exp. Biol. Med. 106:202–204.

    CAS  Google Scholar 

  • Snyder, F., Cress, E. A., and Kyker, G.C., 1959. Liver lipid response to intravenous rare earths in rats, J. Lipid Res. 1:125–131.

    CAS  Google Scholar 

  • Snyder, F., Cress, E.A., and Kyker, G.C., 1960a. Rare-earth fatty liver, Nature 185: 480–481.

    CAS  Google Scholar 

  • Snyder, F., Baker, F., Rafter, J., and Kyker, G.C., 1960b. Octanoate oxidation in the cerium-induced fatty liver, Biochim. Biophys. Acta 43:554–555.

    CAS  Google Scholar 

  • Sobek, J. M., and Talburt, D. E., 1968. Effect of the rare earth cerium on Escherichia coli, J.Bacteriol. 95:47–51.

    CAS  Google Scholar 

  • Steffee, C.H., 1959. Histopathologic effects of rare earths administered intraperitioneally to rats. A preliminary report, A.M.A. Arch. Ind. Health 20:414–419.

    CAS  Google Scholar 

  • Steidle, H., and Ding, M., 1929. Beitrage zur Pharmakologie der Seltenen Erdmetalle. II. Mittelung Uber das Yttrium, Naunyn-Schmiedeberg’s Arch. Exp. Pathol. Pharmacol. 141:273–279.

    CAS  Google Scholar 

  • Stineman, C.H., Massaro, E.J., Lown, B.A., Morganti, J. B., and Al-Hakeeb, S., 1978. Cerium tissue/organ distribution and alterations in open field and exploratory behavior following acute exposure of the mouse to cerium (citrate), J. Environ. Pathol. Toxicol. 2:553–570.

    PubMed  CAS  Google Scholar 

  • Strubelt, O., Siegers, C.P., and Younes, M., 1980. The influence of silybin on the hepatotoxic and hypoglycemic effects of praseodymium and other lanthanides, Arzneim.- Forsch. 30:1690–1694.

    CAS  Google Scholar 

  • Swanson, A. A., and Truesdale, A. W., 1971. Elemental analysis in normal and cataractous human lens tissue, Biochem. Biophys. Res. Commun. 45:1488–1496.

    PubMed  CAS  Google Scholar 

  • Talbot, R. B., Davison, F. C., Green, J. W., Reece, W. O., and Vangelder, G., 1965a. Effects of subcutaneous injection of rare earth metals, United States Atomic Energy Department Report 1170.

    Google Scholar 

  • Talbot, R. B., Davison, F. C., and Reece, W. O., 1965b. Inhalation exposure of mice to an aerosol of gadolinium oxide, U.S. Atomic Energy Commission Report COO-1170–6.

    Google Scholar 

  • Talburt, D. E., and Johnson, G.T., 1967. Some effects of rare earth elements and yttrium on microbial growth, Mycologia 59:492–503.

    CAS  Google Scholar 

  • Tandon, S.K., Gaur, J. S., Behari, J., Mathur, A. K., and Singh, G.B., 1977. Effects of monazite on body organs of rats, Environ. Res. 13:347–357.

    PubMed  CAS  Google Scholar 

  • Tang, X., and Li, G., 1983. Effect of cerium on growth of corn seedling and its enzyme pattern, J. Chin. Rare Earth Soc. 1:56–59.

    CAS  Google Scholar 

  • Tapia, R., 1982. Antagonism of the ruthenium red-induced paralysis in mice by 4-amino-pyridine, guanidine and lanthanum, Neurosci. Lett. 30:73–77.

    PubMed  CAS  Google Scholar 

  • Trnovec, T., Pleskova, A., and Chorvat, D., 1974. The effect of carbon tetrachloride on radiocerium metabolism in rats, Strahlentherapie 147:521–530.

    PubMed  CAS  Google Scholar 

  • Tuchweber, B., and Gabbiani, G., 1967. Effect of sodium pyrophosphate on experimental soft tissue calcification and hypercalcemia, Can. J. Physiol. Pharmacol. 45:957–964.

    PubMed  CAS  Google Scholar 

  • Tuchweber, B., and Savoie, L., 1968. Rare earth metals and soft-tissue calcification, Proc. Soc. Exp. Biol. Med. 128:473–476.

    PubMed  CAS  Google Scholar 

  • Tuchweber, B., Trost, R., Salas, M., and Sieck, W., 1976a. Effect of praseodymium nitrate on hepatocytes and Kupffer cells in the rat, Can. J. Physiol. Pharmacol. 54:898–906.

    PubMed  CAS  Google Scholar 

  • Tuchweber, B., Trost, W., Salas, M., and Sieck, R., 1976b. Prevention of praseodymium-induced hepatotoxicity by silybin, Toxicol. Appl. Pharmacol. 38:559–570.

    PubMed  CAS  Google Scholar 

  • Venugopal, B., and Luckey, T. D., 1978. Metal Toxicity in Mammals, Vol. 2, Chemical Toxicity of Metals and Metalloids, Plenum Press, New York, Chapter 3, pp. 101–173.

    Google Scholar 

  • Vincke, E., and Oelkers, H. A., 1938. Zur Pharmakologie der Selterer Erder: Toxizitat und Wirkung auf Stoffwechsel vorgange, Arch. Exp. Path. Pharmakol. 188:465–476.

    CAS  Google Scholar 

  • Vincke, E., 1942. Die blutgerinnungshemmende Wirkung der seltenen Erden, Hoppe-Seyler’s Z. Physiol. Chem. 272:65–80.

    Google Scholar 

  • Vocaturo, G., Colombo, F., Zanoni, M., Rodi, F., Sabbioni, E., and Pietra, R., 1983. Human exposure to heavy metals. Rare earth pneumoconiosis in occupational workers, Chest 83:780–783.

    PubMed  CAS  Google Scholar 

  • Von Lehmann, B., Oberdisse, E., Grajewski, O., and Arntz, H.R., 1975. Subcellular distribution of phospholipids during liver damage induced by rare earths, Arch. Toxicol. 34:89–101.

    PubMed  CAS  Google Scholar 

  • Von Lehmann, B., Arvela, P., Grajewski, O., and Oberdisse, E., 1976. Drug metabolizing enzymes in the rough and smooth endoplasmic reticulum during liver damage induced by rare earths, Naunyn-Schmiedeberg’s Arch. Pharmacol. 293(Suppl. 1):R59.

    Google Scholar 

  • Weinmann, H.-J., Brasch, R.C., Press, W. R., and Wesbey, G. E., 1984. Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent, Am. J. Radiol. 142:619–624.

    CAS  Google Scholar 

  • Whittingham, D. B., 1980. Parthenogenesis in mammals, in Oxford Review of Reproductive Biology (C. E. Finn, ed.), Vol. 2, Clarendon Press, Oxford, pp. 205–210.

    Google Scholar 

  • Wurm, M., 1951. The effect of lanthanum on growth and metabolism of Streptococcus faecalis R., J. Biol. Chem. 192:707–714.

    PubMed  CAS  Google Scholar 

  • Zanni, A.C., 1965. Contribution to the pharmacology of europium, Rev. Fac. Farm. Bioquim. 3:199–240.

    Google Scholar 

  • Zimakov, Yu. A., 1973. Cited in Haley (1979).

    Google Scholar 

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Evans, C.H. (1990). Toxicology and Pharmacology of the Lanthanides. In: Biochemistry of the Lanthanides. Biochemistry of the Elements, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8748-0_8

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