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Impact of Genetic Targets on Cancer Therapy pp 145–164Cite as

Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 779))

Abstract

Non-small cell lung cancer represents a group of heterogeneous diseases. The last decade witnessed significant progress in improving our understanding of the biology of non-small cell lung cancer, which led to the identification of several genetic targets. Those genetic targets were utilized to explain clinical phenomena, such as the occurrence of non-small cell lung cancer in never-smokers, to predict response to conventional chemotherapy and biological agents, and to explain and predict resistance to therapy. The progress in the treatment of non-small cell lung cancer in the last few years was based on a new generation of population-enriched clinical trials that utilized genetic targets such as somatic EGFR mutations and ALK-EML4 mutations. In this review we will discuss the available information about the key genetic markers of non-small cell lung cancer and the pivotal clinical trials that validate the use of those genetic markers in non-small cell lung cancer patients.

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Authors and Affiliations

  1. Department of Medicine, Penn State Hershey Medical Center, 500 University Dr., Hershey, PA, 17033, USA

    Nicholas Lamparella D.O., Amit Barochia M.D. & Salah Almokadem M.D.

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  1. Nicholas Lamparella D.O.
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  2. Amit Barochia M.D.
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  3. Salah Almokadem M.D.
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Correspondence to Salah Almokadem M.D. .

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  1. University Drive 500, Hershey, 17033, Pennsylvania, USA

    Wafik S El-Deiry

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Lamparella, N., Barochia, A., Almokadem, S. (2013). Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer. In: El-Deiry, W. (eds) Impact of Genetic Targets on Cancer Therapy. Advances in Experimental Medicine and Biology, vol 779. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6176-0_6

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