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Biochemical Roles of Eukaryotic Cell Surface Macromolecules pp 131–151Cite as

Angiogenic Response of Endothelial Cells to Fibronectin

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 749))

Abstract

The process of formation of new blood vessels from preexisting vessels is orchestrated by the interplay between cells, soluble factors, membrane-bound factors, and extracellular matrix (ECM) components. New vessels are generated following a program of several distinct steps involving loosening of matrix and intercellular adhesions, degradation of subendothelial matrix, migration and proliferation of endothelial cells (ECs) and the formation of new tubes. During these processes, adhesion of ECs to ECM components and to other interacting cells is important. Under normal physiological conditions, ECs rest on a laminin-rich basement membrane; but during the angiogenic process ECs interact with a fibronectin (FN) rich provisional matrix as they migrate and proliferate. The mechanism underlying the angiogenic effect of FN is discussed in this review. It appears that FN modulates endothelial functions relevant to its survival and angiogenesis in both integrin-dependent and -independent manner.

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Authors and Affiliations

  1. Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, 695 581, India

    V. B. S. Kumar, R. I. Viji, M. S. Kiran & Perumana R. Sudhakaran

  2. Division of Haematology/Oncology, Cincinnati Children’s Hospital, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA

    V. B. S. Kumar

  3. Health Technology Research Center, Hayasi-Cho, Takamastu-Shi, Kagawa, 761-0395, Japan

    M. S. Kiran

  4. School of Biological Sciences, Central University of Kerala, Riverside Transit Campus, Padannakkad, Nileswar, Kasaragod, 671328, India

    Perumana R. Sudhakaran

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  1. V. B. S. Kumar
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  2. R. I. Viji
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  3. M. S. Kiran
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  4. Perumana R. Sudhakaran
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Correspondence to Perumana R. Sudhakaran .

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Editors and Affiliations

  1. Riverside Transit Campus, School of Biological Sciences, Central University of Kerala, Kasargod, 671328, Kerala, India

    Perumana R. Sudhakaran

  2. National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, Delhi, India

    Avadhesha Surolia

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Kumar, V.B.S., Viji, R.I., Kiran, M.S., Sudhakaran, P.R. (2012). Angiogenic Response of Endothelial Cells to Fibronectin. In: Sudhakaran, P., Surolia, A. (eds) Biochemical Roles of Eukaryotic Cell Surface Macromolecules. Advances in Experimental Medicine and Biology, vol 749. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3381-1_10

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