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Mast Cell Biology pp 235–269Cite as

Mast Cells in Lung Inflammation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 716))

Abstract

Mast cells play an important role in the lung in both health and disease. Their primary role is to initiate an appropriate program of inflammation and repair in response to tissue damage initiated by a variety of diverse stimuli. They are important for host immunity against bacterial infection and potentially in the host immune response to non small cell lung cancer. In situations of ongoing tissue damage, the sustained release of numerous pro-inflammatory mediators, proteases and cytokines, contributes to the pathophysiology of lung diseases such as asthma and interstitial lung disease. A key goal is the development of treatments which attenuate adverse mast cell function when administered chronically to humans in vivo. Such therapies may offer a novel approach to the treatment of many life-threatening diseases.

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Authors and Affiliations

  1. Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK

    Elena P. Moiseeva & Peter Bradding

  2. Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK

    Peter Bradding

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  1. Elena P. Moiseeva
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  1. Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    Alasdair M. Gilfillan PhD  & Dean D. Metcalfe MD  & 

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Moiseeva, E.P., Bradding, P. (2011). Mast Cells in Lung Inflammation. In: Gilfillan, A.M., Metcalfe, D.D. (eds) Mast Cell Biology. Advances in Experimental Medicine and Biology, vol 716. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9533-9_13

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