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Forkhead Transcription Factors pp 227–241Cite as

FOXO Transcription Factors: From Cell Fate Decisions to Regulation of Human Female Reproduction

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 665))

Abstract

All key reproductive events in the human ovary and uterus, including follicle activation, ovulation, implantation, decidualization, luteolysis and menstruation, are dependent upon profound tissue remodelling, characterised by cyclical waves of cell proliferation, differentiation, apoptosis, tissue breakdown and regeneration. FOXO transcription factors, an evolutionarily conserved subfamily of the forkhead transcription factors, have emerged as master regulators ofcell fate decision capable ofintegrating avariety ofstress, growth factor and cytokine signaling pathways with the transcription machinery. The ability of FOXOs to regulate seemingly opposing cellular responses, ranging from cell cycle arrest and oxidative stress responses to differentiation and apoptosis, renders these transcription factors indispensable for cyclic tissue remodelling in female reproduction. Conversely, perturbations in the expression or activity of FOXO transcription factors are increasingly linked to common reproductive disorders, such as pregnancy loss, endometriosis, endometrial cancer and primary ovarian insufficiency.

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Authors and Affiliations

  1. Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, W12 ONN, UK

    Jan J. Brosens

  2. Cancer Research UK Labs and Section of Cancer Cell Biology Department of Oncology Imperial College London, Hammer smith Hospital, London, UK

    Miranda S. C. Wilson & Eric W. -F. Lam

Authors
  1. Jan J. Brosens
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  2. Miranda S. C. Wilson
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  3. Eric W. -F. Lam
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Correspondence to Jan J. Brosens .

Editor information

Editors and Affiliations

  1. Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  2. Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  3. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  4. Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  5. Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  6. Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

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© 2009 Landes Bioscience and Springer+Business Media

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Brosens, J.J., Wilson, M.S.C., Lam, E.W.F. (2009). FOXO Transcription Factors: From Cell Fate Decisions to Regulation of Human Female Reproduction. In: Maiese, K. (eds) Forkhead Transcription Factors. Advances in Experimental Medicine and Biology, vol 665. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1599-3_17

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