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Slit-Robo Signaling in Ocular Angiogenesis

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 664))

Abstract

Slit-Robo signaling was firstly discovered as a major repellent pathway at the midline of the central nervous system. Intense investigation found that this pathway also plays an important role in other biological process including angiogenesis. Robo4 is the vascular endothelial cell specific member of Robo family. It was found that Slit-Robo signaling can inhibit endothelial cell migration, tube formation and vascular permeability. Slit-Robo signaling also plays an important role in embryonic and tumor angiogenesis. In animal model of ocular angiogenesis, addition of Slit inhibited laser induced choroidal neovascularization, oxygen induced retinopathy and VEGF induced retinal permeability in a Robo4 dependent manner. Recent data demonstrates that Robo1 and Robo4 form a heterodimer in endothelial cells, The role of this heterodimer in counteracting VEGF signaling is unknown. Further investigation is required to better understand Slit-Robo signaling and develop novel therapy for angiogenesis.

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Acknowledgments

We thank the following support to HC: Kaisi Funds at Sun Yat-sen University, JSIEC Starting grants; to ST: National Key Science and Technology Project from ‘Tenth Five-Year Plan’ of China, National Natural Science Foundation of China; to KZ: National Institutes of Health Grants R01EY14428, R01EY14448, P30EY014800, and GCRCM01-RR00064, Foundation Fighting Blindness, the Macular Vision Research Foundation, Veterans Affairs Merit Award, and Research to Prevent Blindness to NRL: the Ruth L. Kirschstein National Research Service Award.

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Authors and Affiliations

  1. Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, China

    Haoyu Chen & Mingzhi Zhang

  2. Moran Eye Center, University of Utah, Salt Lake City, Utah, 84112, USA

    Haoyu Chen & Kang Zhang

  3. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54S, Xianlie Road, Guangzhou, China

    Shibo Tang

  4. Department of Oncological Sciences and Medicine and Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, 54112, USA

    Nyall R. London & Dean Y. Li

  5. Institute for Genomic Medicine and Shiley Eye Center, University of California at San Diego, La Jolla, CA, 92093-0838, USA

    Kang Zhang

Authors
  1. Haoyu Chen
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  2. Mingzhi Zhang
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  3. Shibo Tang
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  4. Nyall R. London
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  5. Dean Y. Li
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  6. Kang Zhang
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Corresponding author

Correspondence to Haoyu Chen .

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Editors and Affiliations

  1. Health Science Center, University of Oklahoma, Stanton L. Young Blvd. 608, Oklahoma City, 73104, USA

    Robert E. Anderson

  2. Division of Ophthalmology, Cleveland Clinic Foundation, Euclid Ave. 9500, Cleveland, 44195, USA

    Joe G. Hollyfield

  3. School of Medicine, University of California, San Francisco, Kirkham St. 10, San Francisco, 94143, USA

    Matthew M. LaVail

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Chen, H., Zhang, M., Tang, S., London, N.R., Li, D.Y., Zhang, K. (2010). Slit-Robo Signaling in Ocular Angiogenesis. In: Anderson, R., Hollyfield, J., LaVail, M. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 664. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1399-9_52

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