Abstract
Recent years have seen the emergence of advances in imaging technology that enable in vivo evaluation of the living retina. Two of the more promising techniques, spectral domain optical coherence tomography (SD-OCT) and adaptive optics (AO) fundus imaging provide complementary views of the retinal tissue. SD-OCT devices have high axial resolution, allowing assessment of retinal lamination, while the high lateral resolution of AO allows visualization of individual cells. The potential exists to use one modality to interpret results from the other. As a proof of concept, we examined the retina of a 32 year-old male, previously diagnosed with a red-green color vision defect. Previous AO imaging revealed numerous gaps throughout his cone mosaic, indicating that the structure of a subset of cones had been compromised. Whether the affected cells had completely degenerated or were simply morphologically deviant was not clear. Here an AO fundus camera was used to re-examine the retina (~6 years after initial exam) and SD-OCT to examine retinal lamination. The static nature of the cone mosaic disruption combined with the normal lamination on SD-OCT suggests that the affected cones are likely still present.
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Acknowledgments
The authors thank Dr. Alf Dubra for technical assistance with the adaptive optics control software & Dr. Tom Connor for helpful discussion. This study was supported by NIH Grants EY017607, EY001931, & EY014537, Fight for Sight, The E. Matilda Ziegler Foundation for the Blind, The Karl Kirchgessner Foundation, the RD & Linda Peters Foundation, the Gene & Ruth Posner Foundation, and an unrestricted departmental grant from Research to Prevent Blindness. JC is the recipient of a Career Development Award from Research to Prevent Blindness.
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Rha, J. et al. (2010). Spectral Domain Optical Coherence Tomography and Adaptive Optics: Imaging Photoreceptor Layer Morphology to Interpret Preclinical Phenotypes. In: Anderson, R., Hollyfield, J., LaVail, M. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 664. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1399-9_35
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DOI: https://doi.org/10.1007/978-1-4419-1399-9_35
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