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Pediatric and Adolescent Osteosarcoma pp 509–515Cite as

Bone Marrow Micrometastases Studied by an Immunomagnetic Isolation Procedure in Extremity Localized Non-metastatic Osteosarcoma Patients

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 152))

Abstract

Hematogenous spread of tumor cells is an early event in osteosarcoma and present in the majority of patients at primary diagnosis. Eradication of such micrometastases by adjuvant combination chemotherapy is crucial for survival. However, a survival plateau of 60-70% was reached over two decades ago, above which it seems difficult to further advance with the currently available therapies.

In this study we have, by an immunomagnetic isolation procedure, examined the presence and prognostic impact of disseminated tumor cells in bone marrow aspirates taken at primary diagnosis in a cohort of 41 non-metastatic patients with extremity localized, high-grade osteosarcoma.

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Authors and Affiliations

  1. Faculty of Medicine, University of Oslo and Dept. of Oncology, The Norwegian Radium Hospital, N-0310, Oslo, Norway

    Øyvind S. Bruland

Authors
  1. Øyvind S. Bruland
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  2. Hanne Høifødt
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  3. Kirsten Sundby Hall
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  4. Sigbjørn Smeland
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  5. Øystein Fodstad
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Corresponding author

Correspondence to Øyvind S. Bruland .

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Editors and Affiliations

  1. MD Anderson Cancer Center, University of Texas, Holcombe Blvd. 1515, Houston, 77030-4095, U.S.A.

    Norman Jaffe

  2. Dept. Medical Oncology, Norwegian Radium Hospital, Ullernschaussee 70, Oslo, 0310, Norway

    Oyvind S. Bruland

  3. Orthopädische Klinik, Olgahospital, Bismarckstraße 8, Stuttgart, 70176, Germany

    Stefan Bielack

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Bruland, Ø.S., Høifødt, H., Hall, K.S., Smeland, S., Fodstad, Ø. (2009). Bone Marrow Micrometastases Studied by an Immunomagnetic Isolation Procedure in Extremity Localized Non-metastatic Osteosarcoma Patients. In: Jaffe, N., Bruland, O., Bielack, S. (eds) Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0284-9_30

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  • DOI: https://doi.org/10.1007/978-1-4419-0284-9_30

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0283-2

  • Online ISBN: 978-1-4419-0284-9

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