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Aids-Associated Viral Oncogenesis pp 69–127Cite as

Molecular Biology of KSHV in Relation to AIDS-Associated Oncogenesis

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 133))

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References

  1. Leads from the MMWR. 1986. Classification system for human T-lymphotropic virus type III/lymphadenopathy-associated virus infections. JAMA 256:20–1, 24–5.

    Google Scholar 

  2. 2006. UNAIDS Reference Group on estimates, modelling and projections – statement on the use of the BED assay for the estimation of HIV-1 incidence for surveillance or epidemic monitoring. Wkly Epidemiol Rec 81:40.

    Google Scholar 

  3. Ablashi, D. V., L. G. Chatlynne, J. E. Whitman, Jr., and E. Cesarman. 1997. Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases. Clin Microbiol Rev 15:439–64.

    Google Scholar 

  4. Adams, D. H., and A. R. Lloyd. 1997. Chemokines: leukocyte recruitment and activation cytokines. Lancet 349:490–5.

    PubMed  CAS  Google Scholar 

  5. Akula, S. M., P. P. Naranatt, N. S. Walia, F. Z. Wang, B. Fegley, and B. Chandran. 2003. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) infection of human fibroblast cells occurs through endocytosis. J Virol 77:7978–90.

    PubMed  CAS  Google Scholar 

  6. Akula, S. M., N. P. Pramod, F. Z. Wang, and B. Chandran. 2001. Human herpesvirus 8 envelope-associated glycoprotein B interacts with heparan sulfate-like moieties. Virology 284:235–49.

    PubMed  CAS  Google Scholar 

  7. Akula, S. M., N. P. Pramod, F. Z. Wang, and B. Chandran. 2002. Integrin alpha3beta1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Cell 108:407–19.

    PubMed  CAS  Google Scholar 

  8. Akula, S. M., F. Z. Wang, J.Vieira, and B. Chandran. 2001. Human herpesvirus 8 interaction with target cells involves heparan sulfate. Virology 282:245–55.

    PubMed  CAS  Google Scholar 

  9. Albini, A., I. Paglieri, G. Orengo, S. Carlone, M. G. Aluigi, R. DeMarchi, C. Matteucci, A. Mantovani, F. Carozzi, S. Donini, and R. Benelli. 1997. The beta-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line. AIDS 11:713–21.

    PubMed  CAS  Google Scholar 

  10. Alexander, L., L. Denekamp, A. Knapp, M. R. Auerbach, B. Damania, and R. C. Desrosiers. 2000. The primary sequence of rhesus monkey rhadinovirus isolate 26–95: sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577. J Virol 74:3388–98.

    PubMed  CAS  Google Scholar 

  11. Amin, H. M., L. J.Medeiros, J.T. Manning, and D. Jones. 2003. Dissolution of the lymphoid follicle is a feature of the HHV8+ variant of plasma cell Castleman's disease. Am J Surg Pathol 27:91–100.

    PubMed  Google Scholar 

  12. An, J., A.K. Lichtenstein, G. Brent, and M. B. Rettig. 2002. The Kaposi's sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element. Blood 99:649–54.

    PubMed  CAS  Google Scholar 

  13. An, J., Y. Sun, and M. B. Rettig. 2004. Transcriptional coactivation of c-Jun by the KSHV-encoded LANA. Blood 103:222–8.

    PubMed  CAS  Google Scholar 

  14. An, J., Y. Sun, R. Sun, and M. B. Rettig. 2003. Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways. Oncogene 22:3371–85.

    PubMed  CAS  Google Scholar 

  15. Aoki, Y., E. S. Jaffe, Y. Chang, K. Jones, J.Teruya-Feldstein, P. S. Moore, and G. Tosato. 1999. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood 93:4034–43.

    PubMed  CAS  Google Scholar 

  16. Aoki, Y., and G. Tosato. 2004. HIV-1 Tat enhances Kaposi's sarcoma-associated herpesvirus (KSHV) infectivity. Blood 104:810–4.

    PubMed  CAS  Google Scholar 

  17. Aoki, Y., and G. Tosato. 1999. Role of vascular endothelial growth factor/vascular permeability factor in the pathogenesis of Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphomas. Blood 94:4247–54.

    PubMed  CAS  Google Scholar 

  18. Arvanitakis, L., E. Geras-Raaka, A. Varma, M. C. Gershengorn, and E. Cesarman. 1997. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 385:347–50.

    PubMed  CAS  Google Scholar 

  19. AuCoin, D. P., K. S. Colletti, S. A. Cei, I. Papouskova, M. Tarrant, and G. S. Pari. 2004. Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP). Virology 318:542–55.

    PubMed  CAS  Google Scholar 

  20. Baeuerle, P. A., and D. Baltimore. 1996. NF-kappa B: ten years after. Cell 87:13–20.

    PubMed  CAS  Google Scholar 

  21. Bailer, R. T., C. L. Ng-Bautista, G. M. Ness, and S. R. Mallery. 1997. Expression of interleukin-6 receptors and NF-kappa B in AIDS-related Kaposi's sarcoma cell strains. Lymphology 30:63–76.

    PubMed  CAS  Google Scholar 

  22. Bais, C., B. Santomasso, O. Coso, L. Arvanitakis, E. G. Raaka, J. S. Gutkind, A. S. Asch, E. Cesarman, M. C. Gershengorn, E. A. and Mesri. 1998. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 391:86–9.

    PubMed  CAS  Google Scholar 

  23. Bais, C., A. Van Geelen, P. Eroles, A. Mutlu, C. Chiozzini, S. Dias, R. L. Silverstein, S. Rafii, and E. A. Mesri. 2003. Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/KDR. Cancer Cell 3:131–43.

    PubMed  CAS  Google Scholar 

  24. Baldwin, A. S. Jr. 1996. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649–83.

    PubMed  CAS  Google Scholar 

  25. Ballestas, M. E., P. A. Chatis, and K. M. Kaye. 1999. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284:641–4.

    PubMed  CAS  Google Scholar 

  26. Barbera, A. J., M. E. Ballestas, and K. M. Kaye. 2004. The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence. J Virol 78:294–301.

    PubMed  CAS  Google Scholar 

  27. Barbera, A. J., J. V. Chodaparambil, B. Kelley-Clarke, V. Joukov, J. C. Walter, K. Luger, and K. M. Kaye. 2006. The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science 311:856–61.

    PubMed  CAS  Google Scholar 

  28. Barker, N., P. J. Morin, and H. Clevers. 2000. The Yin-Yang of TCF/beta-catenin signaling. Adv Cancer Res 77:1–24.

    PubMed  CAS  Google Scholar 

  29. Bartel, D. P. 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–97.

    PubMed  CAS  Google Scholar 

  30. Baylin, S. B. 2005. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2(Suppl 1):S4–11.

    PubMed  CAS  Google Scholar 

  31. Bechtel, J.T., Y. Liang, J. Hvidding, and D. Ganem. 2003. Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol 77:6474–81.

    PubMed  CAS  Google Scholar 

  32. Belanger, C., A. Gravel, A. Tomoiu, M. E. Janelle, J. Gosselin, M. J. Tremblay, and L. Flamand. 2001. Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation. J Hum Virol 4:62–73.

    PubMed  CAS  Google Scholar 

  33. Bellows, D. S., B. N. Chau, P. Lee, Y. Lazebnik, W. H. Burns, and J. M. Hardwick. 2000. Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins. J Virol 74:5024–31.

    PubMed  CAS  Google Scholar 

  34. Benelli, R., L. Repetto, S. Carlone, C. Parravicini, and A. Albini. 1994. Establishment and characterization of two new Kaposi's sarcoma cell cultures from an AIDS and a non-AIDS patient. Res Virol 145:251–9.

    PubMed  CAS  Google Scholar 

  35. Beral, V. 1991. Epidemiology of Kaposi's sarcoma. Cancer Surv 10:5–22.

    PubMed  CAS  Google Scholar 

  36. Beral, V., T. A. Peterman, R. L. Berkelman, and H. W. Jaffe. 1990. Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 335:123–8.

    PubMed  CAS  Google Scholar 

  37. Bieleski, L., and S. J. Talbot. 2001. Kaposi's sarcoma-associated herpesvirus vCyclin open reading frame contains an internal ribosome entry site. J Virol 75:1864–9.

    PubMed  CAS  Google Scholar 

  38. Bigoni, B., R. Dolcetti, L. de Lellis, A. Carbone, M. Boiocchi, E. Cassai, and D. Di Luca. 1996. Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS. J Infect Dis 173:542–9.

    PubMed  CAS  Google Scholar 

  39. Birkmann, A., K. Mahr, A. Ensser, S. Yaguboglu, F. Titgemeyer, B. Fleckenstein, and F. Neipel. 2001. Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8.1. J Virol 75:11583–93 (2001).

    PubMed  CAS  Google Scholar 

  40. Borkovic, S. P., and R. A. Schwartz. 1981. Kaposi's sarcoma presenting in the homosexual man – a new and striking phenomenon! Ariz Med 38:902–4.

    PubMed  CAS  Google Scholar 

  41. Boshoff, C., Y. Endo, P. D. Collins, Y. Takeuchi, J. D. Reeves, V. L. Schweickart, M. A. Siani, T. Sasaki, T. J. Williams, P. W. Gray, P. S. Moore, Y. Chang, and R. A. Weiss. 1997. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 278:290–4.

    PubMed  CAS  Google Scholar 

  42. Boshoff, C., S. J. Gao, L. E. Healy, S. Matthews, A. J. Thomas, L. Coignet, R. A. Warnke, J. A. Strauchen, E. Matutes, O. W. Kamel, P. S. Moore, R. A. Weiss, and Y. Chang. 1998. Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice. Blood 91:1671–9.

    PubMed  CAS  Google Scholar 

  43. Boshoff, C., T. F. Schulz, M. M. Kennedy, A. K. Graham, C. Fisher, A. Thomas, J. O. McGee, R. A. Weiss, and J. J. O'Leary. 1995. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1:1274–8.

    PubMed  CAS  Google Scholar 

  44. Boshoff, C., D. Whitby, T. Hatziioannou, C. Fisher, J. van der Walt, A. Hatzakis, R. Weiss, and T. Schulz. 1995. Kaposi's-sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma. Lancet 345:1043–4.

    PubMed  CAS  Google Scholar 

  45. Boulanger, E. 1999. [Human herpesvirus 8 (HHV8). II. Pathogenic role and sensitivity to antiviral drugs]. Ann Biol Clin (Paris) 57:19–28.

    CAS  Google Scholar 

  46. Bower, M., P. Fox, K. Fife, J. Gill, M. Nelson, and B. Gazzard. 1999. Highly active anti-retroviral therapy (HAART) prolongs time to treatment failure in Kaposi's sarcoma. AIDS 13:2105–11.

    PubMed  CAS  Google Scholar 

  47. Bowser, B. S., S. M. DeWire, and B. Damania. 2002. Transcriptional regulation of the K1 gene product of Kaposi's sarcoma-associated herpesvirus. J Virol 76:12574–83.

    PubMed  CAS  Google Scholar 

  48. Bowser, B. S., S. Morris, M. J.Song, R. Sun, and B. Damania. 2006. Characterization of Kaposi's sarcoma-associated herpesvirus (KSHV) K1 promoter activation by Rta. Virology 348:309–27.

    PubMed  CAS  Google Scholar 

  49. Brander, C., T. Suscovich, Y. Lee, P. T. Nguyen, P. O'Connor, J.Seebach, N. G. Jones, M. van Gorder, B. D. Walker, and D. T. Scadden. 2000. Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpesvirus. J Immunol 165:2077–83.

    PubMed  CAS  Google Scholar 

  50. Brantjes, H., N. Barker, J. van Es, and H. Clevers. 2002. TCF: Lady Justice casting the final verdict on the outcome of Wnt signaling. Biol Chem 383:255–61.

    PubMed  CAS  Google Scholar 

  51. Bridges, C. C., H. Hu, S. Miyauchi, U. N. Siddaramappa, M. E. Ganapathy, L. Ignatowicz, D. M. Maddox, S. B. Smith, and V. Ganapathy. 2004. Induction of cystine-glutamate transporter xc-by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium. Invest Ophthalmol Vis Sci 45:2906–14.

    PubMed  Google Scholar 

  52. Brinkmann, M. M., M. Glenn, L. Rainbow, A. Kieser, C. Henke-Gendo, and T. F. Schulz. 2003. Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein. J Virol 77:9346–58.

    PubMed  CAS  Google Scholar 

  53. Briscoe, J., N. C. Rogers, B. A. Witthuhn, D. Watling, A. G. Harpur, A. F. Wilks, G. R. Stark, J. N. Ihle, and I. M. Kerr. 1996. Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state. EMBO J 15:799–809.

    PubMed  CAS  Google Scholar 

  54. Brooks, L. A., A. J. Wilson, and T. Crook. 1997. Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8)–a new human tumor virus. J Pathol 182:262–5.

    PubMed  CAS  Google Scholar 

  55. Brown, E. E., D. Whitby, F. Vitale, P. C. Fei, C. Del Carpio, V. Marshall, A. J. Alberg, D. Serraino, A. Messina, L. Gafa, and J. J. Goedert. 2005. Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi's sarcoma. Int J Epidemiol 34:1110–7.

    PubMed  Google Scholar 

  56. Brown, H. J., M. J. Song, H. Deng, T. T. Wu, G. Cheng, and R. Sun. 2003. NF-kappaB inhibits gammaherpesvirus lytic replication. J Virol 77:8532–40.

    PubMed  CAS  Google Scholar 

  57. Brown, L. F., B. J.Dezube, K. Tognazzi, H. F. Dvorak, and G. D. Yancopoulos. 2000. Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol 156:2179–83.

    PubMed  CAS  Google Scholar 

  58. Browning, P. J., J. M. Sechler, M. Kaplan, R. H. Washington, R. Gendelman, R. Yarchoan, B. Ensoli, and R. C. Gallo. 1994. Identification and culture of Kaposi's sarcoma-like spindle cells from the peripheral blood of human immunodeficiency virus-1-infected individuals and normal controls. Blood 84:2711–20.

    PubMed  CAS  Google Scholar 

  59. Burysek, L., and P. M. Pitha. 2001. Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase. J Virol 75:2345–52.

    PubMed  CAS  Google Scholar 

  60. Burysek, L., W. S. Yeow, B. Lubyova, M. Kellum, S. L. Schafer, Y. Q. Huang, and P. M. Pitha. 1999. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. J Virol 73:7334–42.

    PubMed  CAS  Google Scholar 

  61. Burysek, L., W. S. Yeow, and P. M. Pitha. 1999. Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2). J Hum Virol 2:19–32.

    PubMed  CAS  Google Scholar 

  62. Cai, X., and B. R. Cullen. 2006. Transcriptional origin of Kaposi's sarcoma-associated herpesvirus microRNAs. J Virol 80:2234–42.

    PubMed  CAS  Google Scholar 

  63. Cai, X., S. Lu, Z. Zhang, C. M. Gonzalez, B. Damania, and B. R. Cullen. 2005. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci USA 102:5570–5.

    PubMed  CAS  Google Scholar 

  64. Cannon, M., E. Cesarman, and C. Boshoff. 2006. KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2. Blood 107:277–84.

    PubMed  CAS  Google Scholar 

  65. Cannon, M. L., and E. Cesarman. 2004. The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells. Oncogene 23:514–23.

    PubMed  CAS  Google Scholar 

  66. Carbone, A., A. M. Cilia, A. Gloghini, V. Canzonieri, C. Pastore, M. Todesco, M. Cozzi, T. Perin, R. Volpe, A. Pinto, and G. Gaidano. 1997. Establishment of HHV-8-positive and HHV-8-negative lymphoma cell lines from primary lymphomatous effusions. Int J Cancer 73: 562–9.

    PubMed  CAS  Google Scholar 

  67. Carbone, A., A. M. Cilia, A. Gloghini, D. Capello, L. Fassone, T. Perin, D. Rossi, V. Canzonieri, P. De Paoli, E. Vaccher, U. Tirelli, R. Volpe, and G. Gaidano. 2000. Characterization of a novel HHV-8-positive cell line reveals implications for the pathogenesis and cell cycle control of primary effusion lymphoma. Leukemia 14:1301–9.

    PubMed  CAS  Google Scholar 

  68. Carbone, A., A. M. Cilia, A. Gloghini, D. Capello, M. Todesco, S. Quattrone, R. Volpe, and G. Gaidano. 1998. Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harboring human herpesvirus type-8. Br J Haematol 102:1081–9.

    PubMed  CAS  Google Scholar 

  69. Carbone, A., and G. Gaidano. 1997. HHV-8-positive body-cavity-based lymphoma: a novel lymphoma entity. Br J Haematol 97:515–22.

    PubMed  CAS  Google Scholar 

  70. Carmeliet, P. 2005. Angiogenesis in life, disease and medicine. Nature 438:932–6.

    PubMed  CAS  Google Scholar 

  71. Carroll, P. A., E. Brazeau, and M. Lagunoff. 2004. Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation. Virology 328:7–18.

    PubMed  CAS  Google Scholar 

  72. Casalone, R., A. Albini, R. Righi, P. Granata, and A. Toniolo. 2001. Nonrandom chromosome changes in Kaposi's sarcoma: cytogenetic and FISH results in a new cell line (KS-IMM) and literature review. Cancer Genet Cytogenet 124:16–9.

    PubMed  CAS  Google Scholar 

  73. Caselli, E., M. Galvan, E. Cassai, A. Caruso, L. Sighinolfi, and D. Di Luca. 2005. Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells. Blood 106:2790–7.

    PubMed  CAS  Google Scholar 

  74. Caselli, E., M. Galvan, E. Cassai, and D. Di Luca. 2003. Transient expression of human herpesvirus-8 (Kaposi's sarcoma-associated herpesvirus) ORF50 enhances HIV-1 replication. Intervirology 46:141–9.

    PubMed  CAS  Google Scholar 

  75. Caselli, E., M. Galvan, F. Santoni, A. Rotola, A. Caruso, E. Cassai, and D. D. Luca. Human herpesvirus-8 (Kaposi's sarcoma-associated virus) ORF50 increases invitro cell susceptibility to human immunodeficiency virus type 1 infection. J Gen Virol 84:1123–31.

    Google Scholar 

  76. Caselli, E., P. Menegazzi, A. Bracci, M. Galvan, E. Cassai, and D. Di Luca. 2001. Human herpesvirus-8 (Kaposi's sarcoma-associated herpesvirus) ORF50 interacts synergistically with the tat gene product in transactivating the human immunodeficiency virus type 1 LTR. J Gen Virol 82:1965–70 (2001).

    PubMed  CAS  Google Scholar 

  77. Cathomas, G. 2003. Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) as a tumor virus. Herpes 10:72–7.

    PubMed  Google Scholar 

  78. Cerimele, F., F. Curreli, S. Ely, A. E. Friedman-Kien, E. Cesarman, and O. Flore. 2001. Kaposi's sarcoma-associated herpesvirus can productively infect primary human keratinocytes and alter their growth properties. J Virol 75:2435–43.

    PubMed  CAS  Google Scholar 

  79. Cesarman, E. 2002. The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases. Recent Results Cancer Res 159:27–37.

    PubMed  CAS  Google Scholar 

  80. Cesarman, E., Y. Chang, P. S. Moore, J. W. Said, and D. M. Knowles. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332:1186–91.

    PubMed  CAS  Google Scholar 

  81. Chan, J., S. Kravcik, and J. B. Angel. 1999. Development of Kaposi's sarcoma despite sustained suppression of HIV plasma viremia. J Acquir Immune Defic Syndr 22:209–10.

    PubMed  CAS  Google Scholar 

  82. Chandran, B., C. Bloomer, S. R. Chan, L. Zhu, E. Goldstein, and R. Horvat. 1998. Human herpesvirus-8 ORF K8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts. Virology 249:140–9.

    PubMed  CAS  Google Scholar 

  83. Chang, H., D. P. Dittmer, S. Y. Chul, Y. Hong, and J. U. Jung. 2005. Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression. J Virol 79:14371–82.

    PubMed  CAS  Google Scholar 

  84. Chang, H., Y. Gwack, D. Kingston, J. Souvlis, X. Liang, R. E. Means, E. Cesarman, L. Hutt-Fletcher, and J. U. Jung. 2005. Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. J Virol 79:4651–63.

    PubMed  CAS  Google Scholar 

  85. Chang, H. K., R. Gendelman, J. Lisziewicz, R. C. Gallo, and B. Ensoli. 1994. Block of HIV-1 infection by a combination of antisense tat RNA and TAR decoys: a strategy for control of HIV-1. Gene Ther 1:208–16.

    PubMed  CAS  Google Scholar 

  86. Chang, J., R. Renne, D. Dittmer, and D. Ganem. 2000. Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology 266:17–25.

    PubMed  CAS  Google Scholar 

  87. Chang, P. J., D. Shedd, L. Gradoville, M. S. Cho, L. W. Chen, J. Chang, and G. Miller. 2002. Open reading frame 50 protein of Kaposi's sarcoma-associated herpesvirus directly activates the viral PAN and K12 genes by binding to related response elements. J Virol 76:3168–78.

    PubMed  CAS  Google Scholar 

  88. Chang, P. J., D. Shedd, and G. Miller. 2005. Two subclasses of Kaposi's sarcoma-associated herpesvirus lytic cycle promoters distinguished by open reading frame 50 mutant proteins that are deficient in binding to DNA. J Virol 79:8750–63.

    Google Scholar 

  89. Chang, Y., E. Cesarman, M. S. Pessin, F. Lee, J.Culpepper, D. M. Knowles, and P. S. Moore. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865–9.

    PubMed  CAS  Google Scholar 

  90. Chang, Y., P. S. Moore, S. J. Talbot, C. H. Boshoff, T. Zarkowska, K. Godden, H. Paterson, R. A. Weiss, and S. Mittnacht. 1996. Cyclin encoded by KS herpesvirus. Nature 382:410.

    PubMed  CAS  Google Scholar 

  91. Chang, Y., J. Ziegler, H. Wabinga, E. Katangole-Mbidde, C. Boshoff, T. Schulz, D. Whitby, D. Maddalena, H. W. Jaffe, R. A. Weiss, and P. S. Moore. 1996. Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group. Arch Intern Med 156:202–4.

    PubMed  CAS  Google Scholar 

  92. Chatterjee, M., J. Osborne, G. Bestetti, Y. Chang, and P. S. Moore. 2002. Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science 298:1432–5.

    PubMed  CAS  Google Scholar 

  93. Chaudhary, P. M., A. Jasmin, M. T. Eby, and L. Hood. 1999. Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. Oncogene 18:5738–46.

    PubMed  CAS  Google Scholar 

  94. Chehimi, J., Q. Luo, L. Azzoni, L. Shawver, N. Ngoubilly, R. June, G. Jerandi, M. Farabaugh, and L. J. Montaner. 2003. HIV-1 transmission and cytokine-induced expression of DC-SIGN in human monocyte-derived macrophages. J Leukoc Biol 74:757–63.

    PubMed  CAS  Google Scholar 

  95. Chen, J., K. Ueda, S. Sakakibara, T. Okuno, C. Parravicini, M. Corbellino, and K. Yamanishi. 2001. Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proc Natl Acad Sci USA 98:4119–24.

    PubMed  CAS  Google Scholar 

  96. Chen, J., K. Ueda, S. Sakakibara, T. Okuno, and K. Yamanishi. 2000. Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene. J Virol 74:8623–34.

    PubMed  CAS  Google Scholar 

  97. Chen, S., K. B. Bacon, L. Li, G. E. Garcia, Y. Xia, D. Lo, D. A. Thompson, M. A. Siani, T. Yamamoto, J. K. Harrison, and L. Feng. 1998. In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II. J Exp Med 188:193–8.

    PubMed  CAS  Google Scholar 

  98. Cheng, E. H., J. Nicholas, D. S. Bellows, G. S. Hayward, H. G. Guo, M. S. Reitz, and J. M. Hardwick. 1997. A Bcl-2 homolog encoded by Kaposi's sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak. Proc Natl Acad Sci USA 94:690–4.

    PubMed  CAS  Google Scholar 

  99. Cheung, T. W. 2004. AIDS-related cancer in the era of highly active antiretroviral therapy (HAART): a model of the interplay of the immune system, virus, and cancer. “On the offensive–the Trojan Horse is being destroyed”–Part A: Kaposi's sarcoma. Cancer Invest 22:774–86.

    PubMed  CAS  Google Scholar 

  100. Child, E. S., and D. J. Mann. 2001. Novel properties of the cyclin encoded by Human Herpesvirus 8 that facilitate exit from quiescence. Oncogene 20:3311–22.

    PubMed  CAS  Google Scholar 

  101. Chiou, C. J., L. J. Poole, P. S. Kim, D. M. Ciufo, J. S. Cannon, C. M. ap Rhys, D. J. Alcendor, J. C. Zong, R. F. Ambinder, and G. S. Hayward. Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirus. J Virol 76:3421–39.

    Google Scholar 

  102. Choi, J., R. E. Means, B. Damania, and J. U. Jung. 2001. Molecular piracy of Kaposi's sarcoma associated herpesvirus. Cytokine Growth Factor Rev 12:245–57.

    PubMed  CAS  Google Scholar 

  103. Choi, J. K., B. S. Lee, S. N. Shim, M. Li, and J. U. Jung. 2000. Identification of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome. J Virol 74:436–46.

    PubMed  CAS  Google Scholar 

  104. Chow, D., X. He, A. L. Snow, S. Rose-John, and K. C. Garcia. 2001. Structure of an extracellular gp130 cytokine receptor signaling complex. Science 291:2150–5.

    PubMed  CAS  Google Scholar 

  105. Chung, Y. H., R. E. Means, J. K. Choi, B. S. Lee, and J. U. Jung. 2002. Kaposi's sarcoma-associated herpesvirus OX2 glycoprotein activates myeloid-lineage cells to induce inflammatory cytokine production. J Virol 76:4688–98.

    PubMed  CAS  Google Scholar 

  106. Ciufo, D. M., J. S. Cannon, L. J. Poole, F. Y. Wu, P. Murray, R. F. Ambinder, and G. S. Hayward. 2001. Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures. J Virol 75:5614–26.

    PubMed  CAS  Google Scholar 

  107. Cohen, A., C. Brodie, and R. Sarid. 2006. An essential role of ERK signaling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus. J Gen Virol 87:795–802.

    PubMed  CAS  Google Scholar 

  108. Cool, C. D., P. R. Rai, M. E. Yeager, D. Hernandez-Saavedra, A. E. Serls, T. M. Bull, M. W. Geraci, K. K. Brown, J. M. Routes, R. M. Tuder, and N. F. Voelkel. 2003. Expression of human herpesvirus 8 in primary pulmonary hypertension. N Engl J Med 349:1113–22.

    PubMed  CAS  Google Scholar 

  109. Corbellino, M., L. Poirel, J. T. Aubin, M. Paulli, U. Magrini, G. Bestetti, M. Galli, and C. Parravicini. 1996. The role of human herpesvirus 8 and Epstein-Barr virus in the pathogenesis of giant lymph node hyperplasia (Castleman's disease). Clin Infect Dis 22:1120–1.

    PubMed  CAS  Google Scholar 

  110. Coscoy, L., and D. Ganem. 2000. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc Natl Acad Sci USA 97:8051–6.

    PubMed  CAS  Google Scholar 

  111. Coscoy, L., and D. Ganem. 2001. A viral protein that selectively downregulates ICAM-1 and B7–2 and modulates T cell costimulation. J Clin Invest 107:1599–606.

    PubMed  CAS  Google Scholar 

  112. Cotter, M. A., 2nd, and E. S. Robertson. 1999. The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virology 264:254–64.

    PubMed  CAS  Google Scholar 

  113. Cotter, M. A., 2nd, and E. S. Robertson. 2002. Molecular biology of Kaposi's sarcoma-associated herpesvirus. Front Biosci 7:d358–75.

    PubMed  CAS  Google Scholar 

  114. Couty, J. P., E. Geras-Raaka, B. B. Weksler, and M. C. Gershengorn. 2001. Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor signals through multiple pathways in endothelial cells. J Biol Chem 276:33805–11.

    PubMed  CAS  Google Scholar 

  115. Dagna, L., F. Broccolo, C. T. Paties, M. Ferrarini, L. Sarmati, L. Praderio, M. G. Sabbadini, P. Lusso, and M. S. Malnati. 2005. A relapsing inflammatory syndrome and active human herpesvirus 8 infection. N Engl J Med 353: 156–63.

    PubMed  CAS  Google Scholar 

  116. Damania, B., J. H. Jeong, B. S. Bowser, S. M. DeWire, M. R. Staudt, and D. P. Dittmer. 2004. Comparison of the Rta/Orf50 transactivator proteins of gamma-2-herpesviruses. J Virol 78:5491–9.

    PubMed  CAS  Google Scholar 

  117. Davis, D. A., A. S. Rinderknecht, J. P. Zoeteweij, Y. Aoki, E. L. Read-Connole, G. Tosato, A. Blauvelt, and R. Yarchoan. 2001. Hypoxia induces lytic replication of Kaposi's sarcoma-associated herpesvirus. Blood 97:3244–50.

    PubMed  CAS  Google Scholar 

  118. Dedicoat, M., and R. Newton. 2003. Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma. Br J Cancer 88:1–3.

    PubMed  CAS  Google Scholar 

  119. Delli Bovi, P., E. Donti, D. M. Knowles, 2nd, A. Friedman-Kien, P. A. Luciw, D. Dina, R. Dalla-Favera, and C. Basilico. 1986. Presence of chromosomal abnormalities and lack of AIDS retrovirus DNA sequences in AIDS-associated Kaposi's sarcoma. Cancer Res 46:6333–8.

    PubMed  CAS  Google Scholar 

  120. Deng, H., J. T. Chu, M. B. Rettig, O. Martinez-Maza, and R. Sun. 2002. Rta of the human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. Blood 100:1919–21.

    PubMed  CAS  Google Scholar 

  121. Deng, H., A. Young, and R. Sun. 2000. Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus. J Gen Virol 81:3043–8.

    PubMed  CAS  Google Scholar 

  122. Deng, J. H., Y. J. Zhang, X. P. Wang, and S. J. Gao. 2004. Lytic replication-defective Kaposi's sarcoma-associated herpesvirus: potential role in infection and malignant transformation. J Virol 78:11108–20.

    PubMed  CAS  Google Scholar 

  123. Deutsch, E., A. Cohen, G. Kazimirsky, S. Dovrat, H. Rubinfeld, C. Brodie, and R. Sarid. 2004. Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol 78:10187–92.

    PubMed  CAS  Google Scholar 

  124. Dezube, B. J., M. Zambela, D. R. Sage, J. F. Wang, and J. D. Fingeroth. 2002. Characterization of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 infection of human vascular endothelial cells: early events. Blood 100:888–96.

    PubMed  CAS  Google Scholar 

  125. Dittmer, D., M. Lagunoff, R. Renne, K. Staskus, A. Haase, and D. Ganem. 1998. A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J Virol 72:8309–15.

    PubMed  CAS  Google Scholar 

  126. Dittmer, D., C. Stoddart, R. Renne, V. Linquist-Stepps, M. E. Moreno, C. Bare, J. M. McCune, and D. Ganem. 1999. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J Exp Med 190:1857–68.

    PubMed  CAS  Google Scholar 

  127. Dittmer, D. P. 2003. Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arrays. Cancer Res 63:2010–5.

    PubMed  CAS  Google Scholar 

  128. Djerbi, M., V. Screpanti, A. I. Catrina, B. Bogen, P. Biberfeld, and A. Grandien. 1999. The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. JExp Med 190:1025–32.

    CAS  Google Scholar 

  129. Dourmishev, L. A., A. L. Dourmishev, D. Palmeri, R. A. Schwartz, and D. M. Lukac. 2003. Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol Mol Biol Rev 67:175–212.

    PubMed  CAS  Google Scholar 

  130. Dunaief, J. L., B. E. Strober, S. Guha, P. A. Khavari, K. Alin, J. Luban, M. Begemann, G. R. Crabtree, and S. P. Goff. 1994. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79:119–30.

    PubMed  CAS  Google Scholar 

  131. Dupin, N., T. L. Diss, P. Kellam, M. Tulliez, M. Q. Du, D. Sicard, R. A. Weiss, P. G. Isaacson, and C. Boshoff. 2000. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood 95:1406–12.

    PubMed  CAS  Google Scholar 

  132. Dupin, N., C. Fisher, P. Kellam, S. Ariad, M. Tulliez, N. Franck, E. van Marck, D. Salmon, I. Gorin, J. P. Escande, R. A. Weiss, K. Alitalo, and C. Boshoff C. 1999. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc Natl Acad Sci USA 96:4546–51.

    Google Scholar 

  133. Dupin, N., I. Gorin, J. Deleuze, H. Agut, J. M. Huraux, and J. P. Escande. 1995. Herpes-like DNA sequences, AIDS-related tumors, and Castleman's disease. N Engl J Med 333:798.

    PubMed  CAS  Google Scholar 

  134. Dupin, N., M. Grandadam, V. Calvez, I. Gorin, J. T. Aubin, S. Havard, F. Lamy, M. Leibowitch, J. M. Huraux, J. P. Escande, and etal. 1995. Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma. Lancet 345:761–2.

    PubMed  CAS  Google Scholar 

  135. Duprez, R., E. Kassa-Kelembho, S. Plancoulaine, J. Briere, M. Fossi, L. Kobangue, P. Minsart, M. Huerre, and A. Gessain. 2005. Human herpesvirus 8 serological markers and viral load in patients with AIDS-associated Kaposi's sarcoma in Central African Republic. J Clin Microbiol 43:4840–3.

    PubMed  Google Scholar 

  136. Ellis, M., Y. P. Chew, L. Fallis, S. Freddersdorf, C. Boshoff, R. A. Weiss, X. Lu, and S. Mittnacht. 1999. Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin–cdk6 complex. EMBO J 18:644–53.

    PubMed  CAS  Google Scholar 

  137. Ensoli, B., C. Sgadari, G. Barillari, M. C. Sirianni, M. Sturzl, and P. Monini. 2001. Biology of Kaposi's sarcoma. Eur J Cancer 37:1251–69.

    PubMed  CAS  Google Scholar 

  138. Ensoli, B., and M. C. Sirianni. 1998. Kaposi's sarcoma pathogenesis: a link between immunology and tumor biology. Crit Rev Oncog 9:107–24.

    PubMed  CAS  Google Scholar 

  139. Ensoli, B., and M. Sturzl. 1998. Kaposi's sarcoma: a result of the interplay among inflammatory cytokines, angiogenic factors and viral agents. Cytokine Growth Factor Rev 9:63–83.

    PubMed  CAS  Google Scholar 

  140. Ensoli, B., M. Sturzl, and P. Monini. 2001. Reactivation and role of HHV-8 in Kaposi's sarcoma initiation. Adv Cancer Res 81:161–200.

    PubMed  CAS  Google Scholar 

  141. Fakhari, F. D., J. H. Jeong, Y. Kanan, and D. P. Dittmer. 2006. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma. J Clin Invest 116:735–42.

    PubMed  CAS  Google Scholar 

  142. Fardet, L., L. Blum, D. Kerob, F. Agbalika, L. Galicier, A. Dupuy, M. Lafaurie, V. Meignin, P. Morel, and C. Lebbe. Human herpesvirus 8-associated hemophagocytic lymphohistiocytosis in human immunodeficiency virus-infected patients. Clin Infect Dis 37:285–91.

    Google Scholar 

  143. Feng, P., J. Park, B. S. Lee, S. H. Lee, R. J. Bram, and J. U. Jung. 2002. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J Virol 76:11491–504.

    PubMed  CAS  Google Scholar 

  144. Fickenscher, H., and B. Fleckenstein. 2001. Herpesvirus saimiri. Philos Trans R Soc Lond B Biol Sci 356:545–67.

    PubMed  CAS  Google Scholar 

  145. Field, N., W. Low, M. Daniels, S. Howell, L. Daviet, C. Boshoff, and M. Collins. 2003. KSHV vFLIP binds to IKK-gamma to activate IKK. J Cell Sci 116:3721–8.

    PubMed  CAS  Google Scholar 

  146. Fife, K., M. R. Howard, F. Gracie, R. H. Phillips, and M. Bower. 1998. Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titer. Int J STD AIDS 9:751–5.

    PubMed  CAS  Google Scholar 

  147. Flore, O., S. Rafii, S. Ely, J.J. O'Leary, E. M. Hyjek, and E. Cesarman. 1998. Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature 394:588–92.

    PubMed  CAS  Google Scholar 

  148. Flowers, C. C., S. P. Flowers, and G. J. Nabel. 1998. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor confers resistance to the antiproliferative effect of interferon-alpha. Mol Med 4:402–12.

    PubMed  CAS  Google Scholar 

  149. Foglieni, C., S. Scabini, D. Belloni, F. Broccolo, P. Lusso, M. S. Malnati, and E. Ferrero. 2005. Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformations. Eur J Histochem 49:273–84.

    PubMed  CAS  Google Scholar 

  150. Folkman, J. 2006. Angiogenesis. Annu Rev Med 57:1–18.

    PubMed  CAS  Google Scholar 

  151. Foreman, K. E., J. Friborg, B. Chandran, H. Katano, T. Sata, M. Mercader, G. J. Nabel, and B. J. Nickoloff. 2001. Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions. J Dermatol Sci 26:182–93.

    PubMed  CAS  Google Scholar 

  152. Foreman, K. E., J. Friborg, Jr., W. P. Kong, C. Woffendin, P. J. Polverini, B. J. Nickoloff, and G. J. Nabel. 1997. Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. N Engl J Med 336:163–71.

    PubMed  CAS  Google Scholar 

  153. Foussat, A., J. Wijdenes, L. Bouchet, G. Gaidano, F. Neipel, K. Balabanian, P. Galanaud, J. Couderc, and D. Emilie, D. 1999. Human interleukin-6 is invivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes. Eur Cytokine Netw 10:501–8.

    Google Scholar 

  154. Friborg, J., Jr., W. Kong, M. O. Hottiger, and G. J. Nabel. 1999. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 402:889–94.

    PubMed  CAS  Google Scholar 

  155. Friedman-Kien, A. E. 1981. Disseminated Kaposi's sarcoma syndrome in young homosexual men. J Am Acad Dermatol 5:468–71.

    PubMed  CAS  Google Scholar 

  156. Fujimuro, M., and S. D. Hayward. 2003. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta. J Virol 77:8019–30.

    PubMed  CAS  Google Scholar 

  157. Fujimuro, M., J. Liu, J. Zhu, H. Yokosawa, and S. D. Hayward. 2005. Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen. J Virol 79:10429–41.

    PubMed  CAS  Google Scholar 

  158. Fujimuro, M., F. Y. Wu, C. ApRhys, H. Kajumbula, D. B. Young, G. S. Hayward, and S. D. Hayward. 2003. A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat Med 9:300–6.

    PubMed  CAS  Google Scholar 

  159. Gage, J. R., E. C. Breen, A. Echeverri, L. Magpantay, T. Kishimoto, S. Miles, and O. Martinez-Maza. 1999. Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line. AIDS 13:1851–5.

    PubMed  CAS  Google Scholar 

  160. Gaidano, G., D. Capello, C. Pastore, A. Antinori, A. Gloghini, A. Carbone, L. M. Larocca, and G. Saglio. 1997. Analysis of human herpesvirus type 8 infection in AIDS-related and AIDS-unrelated primary central nervous system lymphoma. J Infect Dis 175:1193–7.

    PubMed  CAS  Google Scholar 

  161. Gaidano, G., and A. Carbone. 2001. Primary effusion lymphoma: a liquid phase lymphoma of fluid-filled body cavities. Adv Cancer Res 80:115–46.

    PubMed  CAS  Google Scholar 

  162. Gaidano, G., K. Cechova, Y. Chang, P. S. Moore, D. M. Knowles, and R. Dalla-Favera. 1996. Establishment of AIDS-related lymphoma cell lines from lymphomatous effusions. Leukemia 10:1237–40.

    PubMed  CAS  Google Scholar 

  163. Gaidano, G., C. Pastore, A. Gloghini, D. Capello, U. Tirelli, G. Saglio, and A. Carbone. 1997. Microsatellite instability in KSHV/HHV-8 positive body-cavity-based lymphoma. Hum Pathol 28:748–50.

    PubMed  CAS  Google Scholar 

  164. Ganem, D. 1998. Human herpesvirus 8 and its role in the genesis of Kaposi's sarcoma. Curr Clin Top Infect Dis 18:237–51.

    PubMed  CAS  Google Scholar 

  165. Gao, S. J., C. Boshoff, S. Jayachandra, R. A. Weiss, Y. Chang, and P. S. Moore. 1997. KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway. Oncogene 15:1979–85.

    PubMed  CAS  Google Scholar 

  166. Gao, S. J., J. H. Deng, and F. C. Zhou. 2003. Productive lytic replication of a recombinant Kaposi's sarcoma-associated herpesvirus in efficient primary infection of primary human endothelial cells. J Virol 77:9738–49.

    PubMed  CAS  Google Scholar 

  167. Gao, S. J., L. Kingsley, D. R. Hoover, T. J. Spira, C. R. Rinaldo, A. Saah, J. Phair, R. Detels, P. Parry, Y. Chang, and P. S. Moore. 1996. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med 335:233–41.

    PubMed  CAS  Google Scholar 

  168. Gao, S. J., L. Kingsley, M. Li, W. Zheng, C. Parravicini, J. Ziegler, R. Newton, C. R. Rinaldo, A. Saah, J. Phair, R. Detels, Y. Chang, and P. S. Moore. 1996. KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med 2:925–8.

    PubMed  CAS  Google Scholar 

  169. Gao, S. J., Y. J. Zhang, J. H. Deng, C. S. Rabkin, O. Flore, and H. B. Jenson. 1999. Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes. J Infect Dis 180:1466–76.

    PubMed  CAS  Google Scholar 

  170. Garber, A. C., M. A. Shu, J. Hu, and R. Renne. 2001. DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol 75:7882–92.

    PubMed  CAS  Google Scholar 

  171. Geijtenbeek, T. B., and Y. van Kooyk. 2003. Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity. Apmis 111:698–714.

    PubMed  CAS  Google Scholar 

  172. Giancotti, F. G., and E. Ruoslahti. 1999. Integrin signaling. Science 285:1028–32.

    PubMed  CAS  Google Scholar 

  173. Giraldo, G., E. Beth, and F. Haguenau. 1972. Herpes-type virus particles in tissue culture of Kaposi's sarcoma from different geographic regions. J Natl Cancer Inst 49:1509–26.

    PubMed  CAS  Google Scholar 

  174. Glenn, M., L. Rainbow, F. Aurade, A. Davison, and T. F. Schulz. 1999. Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus. J Virol 73:6953–63.

    PubMed  CAS  Google Scholar 

  175. Godden-Kent, D., S. J. Talbot, C. Boshoff, Y. Chang, P. Moore, R. A. Weiss, and S. Mittnacht. 1997. The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1. J Virol 71:4193–8.

    PubMed  CAS  Google Scholar 

  176. Goedert, J. J. 2000. The epidemiology of acquired immunodeficiency syndrome malignancies. Semin Oncol 27:390–401.

    PubMed  CAS  Google Scholar 

  177. Goedert, J. J., T. R. Cote, P. Virgo, S. M. Scoppa, D. W. Kingma, M. H. Gail, E. S. Jaffe, and R. J. Biggar. 1998. Spectrum of AIDS-associated malignant disorders. Lancet 351:1833–9.

    PubMed  CAS  Google Scholar 

  178. Gonzalez, C. M., E. L. Wong, B. S. Bowser, G. K. Hong, S. Kenney, and B. Damania. 2006. Identification and characterization of the Orf49 protein of Kaposi's sarcoma-associated herpesvirus. J Virol 80:3062–70.

    PubMed  CAS  Google Scholar 

  179. Goodwin, D. J., M. S. Walters, P. G. Smith, M. Thurau, H. Fickenscher, and A. Whitehouse. 2001. Herpesvirus saimiri open reading frame 50 (Rta) protein reactivates the lytic replication cycle in a persistently infected A549 cell line. J Virol 75:4008–13.

    PubMed  CAS  Google Scholar 

  180. Gottlieb, G. J., A. Ragaz, J. V. Vogel, A. Friedman-Kien, A. M. Rywlin, E. A. Weiner, and A. B. Ackerman. 1981. A preliminary communication on extensively disseminated Kaposi's sarcoma in young homosexual men. Am J Dermatopathol 3:111–4.

    PubMed  CAS  Google Scholar 

  181. Gradoville, L., J. Gerlach, E. Grogan, D. Shedd, S. Nikiforow, C. Metroka, and G. Miller. 2000. Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. J Virol 74:6207–12.

    PubMed  CAS  Google Scholar 

  182. Grisotto, M. G., A. Garin, A. P. Martin, K. K. Jensen, P. Chan, S. C. Sealfon, and S. A. Lira. 2006. The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells. J Clin Invest 116:1264–73.

    PubMed  CAS  Google Scholar 

  183. Grisotto, M. G., A. Garin, A. P. Martin, K. K. Jensen, P. Chan, S. C. Sealfon, and S. A. Lira. 2006. The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells. J Clin Invest 116:1264–73.

    PubMed  CAS  Google Scholar 

  184. Grundhoff, A., and D. Ganem. 2003. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids. J Virol 77:2779–83.

    PubMed  CAS  Google Scholar 

  185. Grundhoff, A., and D. Ganem. 2001. Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus. J Virol 75:1857–63.

    PubMed  CAS  Google Scholar 

  186. Grundhoff, A., C. S. Sullivan, and D. Ganem. 2006. A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA 12:733–50.

    PubMed  CAS  Google Scholar 

  187. Guasparri, I., S. A. Keller, and E. Cesarman. KSHV vFLIP is essential for the survival of infected lymphoma cells. J Exp Med 199:993–1003.

    Google Scholar 

  188. Guasparri, I., H. Wu, and E. Cesarman. 2006. The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signaling. EMBO Rep 7:114–9.

    PubMed  CAS  Google Scholar 

  189. Guo, H. G., S. Pati, M. Sadowska, M. Charurat, and M. Reitz. 2004. Tumorigenesis by human herpesvirus 8 vGPCR is accelerated by human immunodeficiency virus type 1 Tat. J Virol 78:9336–42.

    PubMed  CAS  Google Scholar 

  190. Gwack, Y., H. J. Baek, H. Nakamura, S. H. Lee, M. Meisterernst, R. G. Roeder, and J. U. Jung. 2003. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol 23:2055–67.

    PubMed  CAS  Google Scholar 

  191. Gwack, Y., H. Byun, S. Hwang, C. Lim, and J. Choe. 2001. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol 75:1909–17.

    PubMed  CAS  Google Scholar 

  192. Gwack, Y., S. Hwang, H. Byun, C. Lim, J. W. Kim, E. J. Choi, and J. Choe. 2001. Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis. J Virol 75:6245–8.

    PubMed  CAS  Google Scholar 

  193. Gwack, Y., H. Nakamura, S. H. Lee, J. Souvlis, J. T. Yustein, S. Gygi, H. J. Kung, and J. U. Jung. 2003. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Mol Cell Biol 23. 8282–94.

    PubMed  CAS  Google Scholar 

  194. Han, Z., and S. Swaminathan. 2006. Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. J Virol 80:5251–60.

    PubMed  CAS  Google Scholar 

  195. Haque, M., J. Chen, K. Ueda, Y. Mori, K. Nakano, Y. Hirata, S. Kanamori, Y. Uchiyama, R. Inagi, T. Okuno, and K. Yamanishi. 2000. Identification and analysis of the K5 gene of Kaposi's sarcoma-associated herpesvirus. J Virol 74:2867–75.

    PubMed  CAS  Google Scholar 

  196. Harada, H., T. Fujita, M. Miyamoto, Y. Kimura, M. Maruyama, A. Furia, T. Miyata, and T. Taniguchi. 1989. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58:729–39.

    PubMed  CAS  Google Scholar 

  197. Harada, H., M. Kitagawa, N. Tanaka, H. Yamamoto, K. Harada, M. Ishihara, and T. Taniguchi. 1993. Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science 259:971–4.

    PubMed  CAS  Google Scholar 

  198. Harrington, W., Jr., L. Sieczkowski, C. Sosa, S. Chan-a-Sue, J. P. Cai, L. Cabral, and C. Wood. 1997. Activation of HHV-8 by HIV-1 tat. Lancet 349:774–5.

    PubMed  Google Scholar 

  199. Hayward, S. D. 2004. Viral interactions with the Notch pathway. Semin Cancer Biol 14:387–96.

    PubMed  CAS  Google Scholar 

  200. Helin, K., E. Harlow, and A. Fattaey. 1993. Inhibition of E2F–1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol 13:6501–8.

    PubMed  CAS  Google Scholar 

  201. Hengge, U. R., T. Ruzicka, S. K. Tyring, M. Stuschke, M. Roggendorf, R. A. Schwartz, and S. Seeber. 2002. Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy. Lancet Infect Dis 2:281–92.

    PubMed  Google Scholar 

  202. Hideshima, T., D. Chauhan, G. Teoh., N. Raje, S. P. Treon, Y. T. Tai, Y. Shima, and K. C. Anderson. 2000. Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6. Clin Cancer Res 6:1180–9.

    PubMed  CAS  Google Scholar 

  203. Hiscott, J., N. Grandvaux, S. Sharma, B. R. Tenoever, M. J.Servant, and R. Lin. 2003. Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis. Ann N Y Acad Sci 1010:237–48.

    PubMed  CAS  Google Scholar 

  204. Holkova, B., K. Takeshita, D. M. Cheng, M. Volm, C. Wasserheit, R. Demopoulos, and A. Chanan-Khan. 2001. Effect of highly active antiretroviral therapy on survival in patients with AIDS-associated pulmonary Kaposi's sarcoma treated with chemotherapy. J Clin Oncol 19:3848–51.

    PubMed  CAS  Google Scholar 

  205. Hu, J., A. C. Garber, and R. Renne. 2002. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells. J Virol 76:11677–87.

    PubMed  CAS  Google Scholar 

  206. Huang, L. M., M. F. Chao, M. Y. Chen, H. Shih, Y. P. Chiang, C. Y. Chuang, and C. Y. Lee. 2001. Reciprocal regulatory interaction between human herpesvirus 8 and human immunodeficiency virus type 1. J Biol Chem 276:13427–32.

    PubMed  CAS  Google Scholar 

  207. Huang, Y. Q., A. E. Friedman-Kien, J. J. Li, and B. J.Nickoloff. 1993. Cultured Kaposi's sarcoma cell lines express factor XIIIa, CD14, and VCAM-1, but not factor VIII or ELAM-1. Arch Dermatol 129:1291–6.

    PubMed  CAS  Google Scholar 

  208. Hunter, T., and J. Pines. 1991. Cyclins and cancer. Cell 66:1071–4.

    PubMed  CAS  Google Scholar 

  209. Hwang, S., Y. Gwack, H. Byun, C. Lim, and J. Choe. 2001. The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription. J Virol 75:9509–16.

    PubMed  CAS  Google Scholar 

  210. Hymes, K. B., T. Cheung, J. B. Greene, N. S. Prose, A. Marcus, H. Ballard, D. C. William, and L. J. Laubenstein. 1981. Kaposi's sarcoma in homosexual men-a report of eight cases. Lancet 2:598–600.

    PubMed  CAS  Google Scholar 

  211. Hyun, T. S., C. Subramanian, M. A. Cotter, 2nd, R. A. Thomas, and E. S. Robertson. 2001. Latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus interacts with Tat and activates the long terminal repeat of human immunodeficiency virus type 1 in human cells. J Virol 75:8761–71.

    PubMed  CAS  Google Scholar 

  212. Inoue, N., J. Winter, R. B. Lal, M. K. Offermann, and S. Koyano. 2003. Characterization of entry mechanisms of human herpesvirus 8 by using an Rta-dependent reporter cell line. J Virol 77:8147–52.

    PubMed  CAS  Google Scholar 

  213. Ishido, S., J. K. Choi, B. S. Lee, C. Wang, M. DeMaria, R. P. Johnson, G. B. Cohen, and J. U. Jung. 2000. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. Immunity 13:365–74.

    PubMed  CAS  Google Scholar 

  214. Ishido, S., C. Wang, B. S. Lee, G. B. Cohen, and J. U. Jung. 2000. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J Virol 74:5300–9.

    PubMed  CAS  Google Scholar 

  215. Jacobson, L. P., F. J. Jenkins, G. Springer, A. Munoz, K. V. Shah, J. Phair, Z. Zhang, and H. Armenian. 2000. Interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections on the incidence of Kaposi's sarcoma. J Infect Dis 181:1940–9.

    PubMed  CAS  Google Scholar 

  216. Jarviluoma, A., S. Koopal, S. Rasanen, T. P. Makela, and P. M. Ojala. 2004. KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas. Blood 104:3349–54.

    PubMed  Google Scholar 

  217. Jenner, R. G., M. M. Alba, C. Boshoff, and P. Kellam. 2001. Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays. J Virol 75:891–902.

    PubMed  CAS  Google Scholar 

  218. Jensen, K. K., D. J. Manfra, M. G. Grisotto, A. P. Martin, G. Vassileva, K. Kelley, T. W. Schwartz, and S. A. Lira. 2005. The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma. J Immunol 174:3686–94.

    PubMed  CAS  Google Scholar 

  219. Jeong, J. H., J. Orvis, J. W. Kim, C. P. McMurtrey, R. Renne, and D. P. Dittmer. 2004. Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma- associated herpesvirus. J Biol Chem 279:16822–31.

    PubMed  CAS  Google Scholar 

  220. Johansson, S., G. Svineng, K. Wennerberg, A. Armulik, and L. Lohikangas. 1997. Fibronectin-integrin interactions. Front Biosci 2:d126–46.

    PubMed  CAS  Google Scholar 

  221. Jones, J. L., D. L. Hanson, S. Y. Chu, J. W. Ward, and H. W. Jaffe. 1995. AIDS-associated Kaposi's sarcoma. Science 267:1078–9.

    PubMed  CAS  Google Scholar 

  222. Judde, J. G., V. Lacoste, J. Briere, E. Kassa-Kelembho, E. Clyti, P. Couppie, C. Buchrieser, M. Tulliez, J. Morvan, and A. Gessain. 2000. Monoclonality or oligoclonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases. J Natl Cancer Inst 92:729–36.

    PubMed  CAS  Google Scholar 

  223. Juhasz, I., S. M. Albelda, D. E. Elder, G. F. Murphy, K. Adachi, D. Herlyn, I. T. Valyi-Nagy, and M. Herlyn. 1993. Growth and invasion of human melanomas in human skin grafted to immunodeficient mice. Am J Pathol 143:528–37.

    PubMed  CAS  Google Scholar 

  224. Kaldis, P., P. M. Ojala, L. Tong, T. P. Makela, and M. J. Solomon. 2001. CAK-independent activation of CDK6 by a viral cyclin. Mol Biol Cell 12:3987–99.

    PubMed  CAS  Google Scholar 

  225. Kaleeba, J. A., and E. A. Berger. 2006. Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT. Science 311:1921–4.

    PubMed  CAS  Google Scholar 

  226. Karlin, S., E. S. Mocarski, and G. A. Schachtel. 1994. Molecular evolution of herpesviruses: genomic and protein sequence comparisons. J Virol 68:1886–902.

    PubMed  CAS  Google Scholar 

  227. Katano, H., Y. Sato, T. Kurata, S. Mori, and T. Sata. 2000. Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology 269:335–44.

    PubMed  CAS  Google Scholar 

  228. Katano, H., Y. Sato, and T. Sata. 2001. Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies. Cancer 92:3076–84.

    PubMed  CAS  Google Scholar 

  229. Kedes, D. H., E. Operskalski, M. Busch, R. Kohn, J. Flood, and D. Ganem. 1996. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 2:918–24.

    PubMed  CAS  Google Scholar 

  230. Keller, S. A., D. Hernandez-Hopkins, J. Vider, V. Ponomarev, E. Hyjek, E. J. Schattner, and E. Cesarman. 2006. NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas invivo. Blood 107:3295–302.

    PubMed  CAS  Google Scholar 

  231. Keller, S. A., E. J. Schattner, and E. Cesarman. 2000. Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells. Blood 96:2537–42.

    PubMed  CAS  Google Scholar 

  232. Kirchhausen, T. 2000. Three ways to make a vesicle. Nat Rev Mol Cell Biol 1:187–98.

    PubMed  CAS  Google Scholar 

  233. Kirchhoff, S., T. Sebens, S. Baumann, A. Krueger, R. Zawatzky, M. Li-Weber, E. Meinl, F. Neipel, B. Fleckenstein, and P. H. Krammer. 2002. Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter. J Immunol 168:1226–34.

    PubMed  CAS  Google Scholar 

  234. Kledal, T. N., M. M. Rosenkilde, F. Coulin, G. Simmons, A. H. Johnsen, S. Alouani, C. A. Power, H. R. Luttichau, J. Gerstoft, P. R. Clapham, I. Clark-Lewis, T. N. Wells, and T. W. Schwartz. 1997. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 277:1656–9.

    PubMed  CAS  Google Scholar 

  235. Kliche, S., W. Nagel, E. Kremmer, C. Atzler, A. Ege, T. Knorr, U. Koszinowski, W. Kolanus, and J. Haas. 2001. Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Mol Cell 7:833–43.

    PubMed  CAS  Google Scholar 

  236. Klouche, M., N. Brockmeyer, C. Knabbe, and S. Rose-John. 2002. Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells. AIDS 16:F9–18.

    PubMed  CAS  Google Scholar 

  237. Knipe, D. M., Howley, Peter, M., Fields Virology. Lippincott Williams and Wilkins. 2001.

    Google Scholar 

  238. Komatsu, T., M. E. Ballestas, A. J. Barbera, B. Kelley-Clarke, and K. M. Kaye. 2004. KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence. Virology 319:225–36.

    PubMed  CAS  Google Scholar 

  239. Kouzarides, T. 1999. Histone acetylases and deacetylases in cell proliferation. Curr Opin Genet Dev 9:40–8.

    PubMed  CAS  Google Scholar 

  240. Koyano, S., E. C. Mar, F. R. Stamey, and N. Inoue. Glycoproteins M and N of human herpesvirus 8 form a complex and inhibit cell fusion. J Gen Virol 84:1485–91.

    Google Scholar 

  241. Krishnan, H. H., P. P. Naranatt, M. S. Smith, L. Zeng, C. Bloomer, and B. Chandran. 2004. Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J Virol 78:3601–20.

    PubMed  CAS  Google Scholar 

  242. Krishnan, H. H., N. Sharma-Walia, L. Zeng, S. J. Gao, and B. Chandran. 2005. Envelope glycoprotein gB of Kaposi's sarcoma-associated herpesvirus is essential for egress from infected cells. J Virol 79:10952–67.

    PubMed  CAS  Google Scholar 

  243. Krithivas, A., M. Fujimuro, M. Weidner, D. B. Young, and S. D. Hayward. 2002. Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes. J Virol 76:11596–604.

    PubMed  CAS  Google Scholar 

  244. Krithivas, A., D. B. Young, G. Liao, D. Greene, and S. D. Hayward. 2000. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. J Virol 74:9637–45.

    PubMed  CAS  Google Scholar 

  245. Lacoste, V., C. de la Fuente, F. Kashanchi, and A. Pumfery. 2004. Kaposi's sarcoma-associated herpesvirus immediate early gene activity. Front Biosci 9:2245–72.

    PubMed  CAS  Google Scholar 

  246. Lagunoff, M., J. Bechtel, E. Venetsanakos, A. M. Roy, N. Abbey, B. Herndier, M. McMahon, and D. Ganem. 2002. De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. J Virol 76:2440–8.

    PubMed  CAS  Google Scholar 

  247. Lan, K., D. A. Kuppers, and E. S. Robertson. 2005. Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathway. J Virol 79:3468–78.

    PubMed  CAS  Google Scholar 

  248. Lan, K., D. A. Kuppers, S. C. Verma, and E. S. Robertson. 2004. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency. J Virol 78:6585–94.

    PubMed  CAS  Google Scholar 

  249. Lan, K., D. A. Kuppers, S. C. Verma, N. Sharma, M. Murakami, and E. S. Robertson. 2005. Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency. J Virol 79:7453–65.

    PubMed  CAS  Google Scholar 

  250. Laney, A. S., T. De Marco, J. S. Peters, M. Malloy, C. Teehankee, P. S. Moore, and Y. Chang. 2005. Kaposi's sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension. Chest 127:762–7.

    PubMed  Google Scholar 

  251. Lang, M. E., C. Lottersberger, B. Roth, G. Bock, H. Recheis, R. Sgonc, M. Sturzl, A. Albini, E. Tschachler, R. Zangerle, S. Donini, H. Feichtinger, and S. Schwarz. 1997. Induction of apoptosis in Kaposi's sarcoma spindle cell cultures by the subunits of human chorionic gonadotropin. AIDS 11:1333–40.

    PubMed  CAS  Google Scholar 

  252. Lazzi, S., C. Bellan, T. Amato, N. Palummo, C. Cardone, A. D'Amuri, F. De Luca, M. Beyanga, F. Facchetti, P. Tosi, and L. Leoncini. 2006. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 infection in reactive lymphoid tissues: a model for KSHV/HHV-8-related lymphomas? Hum Pathol 37:23–31.

    PubMed  CAS  Google Scholar 

  253. Lebbe, C., P. de Cremoux, M. Rybojad, C. Costa da Cunha, P. Morel, and F. Calvo. 1995. Kaposi's sarcoma and new herpesvirus. Lancet 345:1180.

    PubMed  CAS  Google Scholar 

  254. Lee, B. S., S. H. Lee, P. Feng, H. Chang, N. H. Cho, and J. U. Jung. 2005. Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome. J Virol 79:12173–84.

    PubMed  CAS  Google Scholar 

  255. Lee, H., R. Veazey, K. Williams, M. Li, J. Guo, F. Neipel, B. Fleckenstein, A. Lackner, R. C. Desrosiers, and J. U. Jung. 1998. Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Nat Med 4:435–40.

    PubMed  CAS  Google Scholar 

  256. Lennette, E. T., M. P. Busch, F. M. Hecht, J. A. and Levy. Potential herpesvirus interaction during HIV type 1 primary infection. AIDS Res Hum Retroviruses 21:869–75.

    Google Scholar 

  257. Li, H., T. Komatsu, B. J. Dezube, and K. M. Kaye. 2002. The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter. J Virol 76:11880–8.

    PubMed  CAS  Google Scholar 

  258. Li, M., B. Damania, X. Alvarez, V. Ogryzko, K. Ozato, and J. U. Jung. 2000. Inhibition of p300 histone acetyltransferase by viral interferon regulatory factor. Mol Cell Biol 20:8254–63.

    PubMed  CAS  Google Scholar 

  259. Li, M., H. Lee, J. Guo, F. Neipel, B. Fleckenstein, K. Ozato, and J. U. Jung. 1998. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor. J Virol 72:5433–40.

    PubMed  CAS  Google Scholar 

  260. Li, M., H. Lee, D. W. Yoon, J. C. Albrecht, B. Fleckenstein, F. Neipel, and J. U. Jung. 1997. Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J Virol 71:1984–91.

    PubMed  CAS  Google Scholar 

  261. Li, M., J. MacKey, S. C. Czajak, R. C. Desrosiers, A. A. Lackner, and J. U. Jung. 1999. Identification and characterization of Kaposi's sarcoma-associated herpesvirus K8.1 virion glycoprotein. J Virol 73:1341–9.

    PubMed  CAS  Google Scholar 

  262. Liang, Y., J. Chang, S. J. Lynch, D. M. Lukac, and D. Ganem. 2002. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes Dev 16:1977–89.

    PubMed  CAS  Google Scholar 

  263. Liang, Y., and D. Ganem. 2003. Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc Natl Acad Sci USA 100: 8490–5.

    PubMed  CAS  Google Scholar 

  264. Liao, W., Y. Tang, Y. L. Kuo, B. Y. Liu, C. J. Xu, and C. Z. Giam. 2003. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 transcriptional activator Rta is an oligomeric DNA-binding protein that interacts with tandem arrays of phased A/T-trinucleotide motifs. J Virol 77:9399–411.

    PubMed  CAS  Google Scholar 

  265. Lim, C., Y. Gwack, S. Hwang, S. Kim, and J. Choe. 2001. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem 276:31016–22.

    PubMed  CAS  Google Scholar 

  266. Lim, C., H. Sohn, Y. Gwack, and J. Choe. 2000. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J Gen Virol 81:2645–52.

    PubMed  CAS  Google Scholar 

  267. Lin, R., P. Genin, Y. Mamane, M. Sgarbanti, A. Battistini, W. J. Harrington Jr., G. N. Barber, and J. Hiscott. 2001. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene 20:800–11.

    PubMed  CAS  Google Scholar 

  268. Lin, S. F., D. R. Robinson, J. Oh, J. U. Jung, P. A. Luciw, and H. J. Kung. 2002. Identification of the bZIP and Rta homologues in the genome of rhesus monkey rhadinovirus. Virology 298:181–8.

    PubMed  CAS  Google Scholar 

  269. Liu, C., Y. Okruzhnov, H. Li, and J. Nicholas. 2001. Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects. J Virol 75:10933–40.

    PubMed  CAS  Google Scholar 

  270. Liu, L., M. T. Eby, N. Rathore, S. K. Sinha, A. Kumar, and P. M. Chaudhary. 2002. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem 277:13745–51.

    PubMed  CAS  Google Scholar 

  271. Locati, M., and P. M. Murphy. 1999. Chemokines and chemokine receptors: biology and clinical relevance in inflammation and AIDS. Annu Rev Med 50:425–40.

    PubMed  CAS  Google Scholar 

  272. Low, W., M. Harries, H. Ye, M. Q. Du, C. Boshoff, and M. Collins. 2001. Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein. J Virol 75:2938–45.

    PubMed  CAS  Google Scholar 

  273. Lu, F., J. Zhou, A. Wiedmer, K. Madden, Y. Yuan, and P. M. Lieberman. 2003. Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. J Virol 77:11425–35.

    PubMed  CAS  Google Scholar 

  274. Lubyova, B., and P. M. Pitha. 2000. Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors. J Virol 74:8194–201.

    PubMed  CAS  Google Scholar 

  275. Lukac, D. M., J. R. Kirshner, and D. Ganem. 1999. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J Virol 73:9348–61.

    PubMed  CAS  Google Scholar 

  276. Lukac, D. M., R. Renne, J. R. Kirshner, and D. Ganem. 1998. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 252:304–12.

    PubMed  CAS  Google Scholar 

  277. Luna, R. E., F. Zhou, A. Baghian, V. Chouljenko, B. Forghani, S. J. Gao, and K. G. Kousoulas. 2004. Kaposi's sarcoma-associated herpesvirus glycoprotein K8.1 is dispensable for virus entry. J Virol 78:6389–98.

    PubMed  CAS  Google Scholar 

  278. Malmgaard, L. 2004. Induction and regulation of IFNs during viral infections. J Interferon Cytokine Res 24:439–54.

    PubMed  CAS  Google Scholar 

  279. Mann, D. J., E. S. Child, C. Swanton, H. Laman, and N. Jones. 1999. Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus. EMBO J 18:654–63.

    PubMed  CAS  Google Scholar 

  280. Martin, R. W., 3rd, A. F. Hood, and E. R. Farmer. 1993. Kaposi's sarcoma. Medicine (Baltimore) 72:245–61.

    Google Scholar 

  281. Masood, R., J. Cai, T. Zheng, D. L. Smith, Y. Naidu, and P. S. Gill. 1997. Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi's sarcoma. Proc Natl Acad Sci USA 94:979–84.

    PubMed  CAS  Google Scholar 

  282. Masood, R., E. Cesarman, D. L. Smith, P. S. Gill, and O. Flore. 2002. Human herpesvirus-8-transformed endothelial cells have functionally activated vascular endothelial growth factor/vascular endothelial growth factor receptor. Am J Pathol 160:23–9.

    PubMed  CAS  Google Scholar 

  283. Masood, R., G. Xia, D. L. Smith, P. Scalia, J. G. Still, A. Tulpule, and P. S. Gill. 2005. Ephrin B2 expression in Kaposi's sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium. Blood 105:1310–8.

    PubMed  CAS  Google Scholar 

  284. Matta, H., and P. M. Chaudhary. 2004. Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP). Proc Natl Acad Sci USA 101:9399–404.

    PubMed  CAS  Google Scholar 

  285. Mattsson, K., C. Kiss, G. M. Platt, G. R. Simpson, E. Kashuba, G. Klein, T. F. Schulz, and L. Szekely. 2002. Latent nuclear antigen of Kaposi's sarcoma herpesvirus/human herpesvirus-8 induces and relocates RING3 to nuclear heterochromatin regions. J Gen Virol 83:179–88.

    PubMed  CAS  Google Scholar 

  286. McAllister, S. C., S. G. Hansen, R. A. Ruhl, C. M. Raggo, V. R. DeFilippis, D. Greenspan, K. Fruh, and A. V. Moses. 2004. Kaposi's sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood 103:3465–73.

    PubMed  CAS  Google Scholar 

  287. McCormick, C., and D. Ganem. 2005. The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs. Science 307:739–41.

    PubMed  CAS  Google Scholar 

  288. McGeoch, D. J., and A. J. Davison. 1999. The descent of human herpesvirus 8. Semin Cancer Biol 9:201–9.

    PubMed  CAS  Google Scholar 

  289. McPherson, P. S., B. K. Kay, and N. K. Hussain. 2001. Signaling on the endocytic pathway. Traffic 2:375–84.

    PubMed  CAS  Google Scholar 

  290. Meads, M. B., and P. G. Medveczky. 2004. Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. J Biol Chem 279:51793–803.

    PubMed  CAS  Google Scholar 

  291. Melbye, M., P. M. Cook, H. Hjalgrim, K. Begtrup, G. R. Simpson, R. J. Biggar, P. Ebbesen, and T. F. Schulz. 1998. Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981–1996. Int J Cancer 77:543–8.

    PubMed  CAS  Google Scholar 

  292. Merat, R., A. Amara, C. Lebbe, H. de The, P. Morel, and A. Saib. 2002. HIV-1 infection of primary effusion lymphoma cell line triggers Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation. Int J Cancer 97:791–5.

    PubMed  CAS  Google Scholar 

  293. Mercader, M., B. J. Nickoloff, and K. E. Foreman. Induction of human immunodeficiency virus 1 replication by human herpesvirus 8. Arch Pathol Lab Med 125:785–9.

    Google Scholar 

  294. Mercader, M., B. Taddeo, J. R. Panella, B. Chandran, B. J. Nickoloff, and K. E. Foreman. 2000. Induction of HHV-8 lytic cycle replication by inflammatory cytokines produced by HIV-1-infected T cells. Am J Pathol 156:1961–71.

    PubMed  CAS  Google Scholar 

  295. Miller, G., L. Heston, E. Grogan, L. Gradoville, M. Rigsby, R. Sun, D. Shedd, V. M. Kushnaryov, S. Grossberg, and Y. Chang. 1997. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J Virol 71:314–24.

    PubMed  CAS  Google Scholar 

  296. Mocroft, A., M. Youle, B. Gazzard, J. Morcinek, R. Halai, and A. N. Phillips. Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group. AIDS 10:1101–5.

    Google Scholar 

  297. Molden, J., Y. Chang, Y. You, P. S. Moore, and M. A. Goldsmith. 1997. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J Biol Chem 272:19625–31.

    PubMed  CAS  Google Scholar 

  298. Montaner, S., A. Sodhi, S. Pece, E. A. Mesri, and J. S. Gutkind. 2001. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Res 61:2641–8.

    PubMed  CAS  Google Scholar 

  299. Montaner, S., A. Sodhi, J. M. Servitja, A. K. Ramsdell, A. Barac, E. T. Sawai, and J. S. Gutkind. 2004. The small GTPase Rac1 links the Kaposi's sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. Blood 104:2903–11.

    PubMed  CAS  Google Scholar 

  300. Moore, P. S., C. Boshoff, R. A. Weiss, and Y. Chang. 1996. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274:1739–44.

    PubMed  CAS  Google Scholar 

  301. Moore, P. S., and Y. Chang. 1995. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N Engl J Med 332:1181–5.

    PubMed  CAS  Google Scholar 

  302. Moore, P. S., and Y. Chang. 2001. Molecular virology of Kaposi's sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci 356:499–516.

    PubMed  CAS  Google Scholar 

  303. Moore, P. S., S. J. Gao, G. Dominguez, E. Cesarman, O. Lungu, D. M. Knowles, R. Garber, P. E. Pellett, D. J. McGeoch, and Y. Chang. 1996. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma. J Virol 70:549–58.

    PubMed  CAS  Google Scholar 

  304. Moore, P. S., L. A. Kingsley, S. D. Holmberg, T. Spira, P. Gupta, D. R. Hoover, J. P. Parry, L. J. Conley, H. W. Jaffe, and Y. Chang. 1996. Kaposi's sarcoma-associated herpesvirus infection prior to onset of Kaposi's sarcoma. AIDS 10:175–80.

    PubMed  CAS  Google Scholar 

  305. Mori, Y., N. Nishimoto, M. Ohno, R. Inagi, P. Dhepakson, K. Amou, K. Yoshizaki, and K. Yamanishi. 2000. Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion. J Med Virol 61:332–5.

    PubMed  CAS  Google Scholar 

  306. Moses, A. V., K. N. Fish, R. Ruhl, P. P. Smith, J. G. Strussenberg, L. Zhu, B. Chandran, and J. A. Nelson. 1999. Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8. J Virol 73:6892–902.

    PubMed  CAS  Google Scholar 

  307. Moynagh, P. N. 2005. TLR signaling and activation of IRFs: revisiting old friends from the NF-kappaB pathway. Trends Immunol 26:469–76.

    PubMed  CAS  Google Scholar 

  308. Mullberg, J., T. Geib, T. Jostock, S. H. Hoischen, P. Vollmer, N. Voltz, D. Heinz, P. R. Galle, M. Klouche, and S. Rose-John. 2000. IL-6 receptor independent stimulation of human gp130 by viral IL-6. J Immunol 164:4672–7.

    PubMed  CAS  Google Scholar 

  309. Mullick, J., J. Bernet, A. K. Singh, J. D. Lambris, and A. Sahu. 2003. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) open reading frame 4 protein (kaposica) is a functional homolog of complement control proteins. J Virol 77:3878–81.

    PubMed  CAS  Google Scholar 

  310. Munshi, N., R. K. Ganju, S. Avraham, E. A. Mesri, and J. E. Groopman. 1999. Kaposi's sarcoma- associated herpesvirus-encoded G protein-coupled receptor activation of c-jun amino-terminal kinase/stress-activated protein kinase and lyn kinase is mediated by related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2. J Biol Chem 274:31863–7.

    PubMed  CAS  Google Scholar 

  311. Muralidhar, S., A. M. Pumfery, M. Hassani, M. R. Sadaie, M. Kishishita, J. N. Brady, J. Doniger, P. Medveczky, and L. J. Rosenthal. 1998. Identification of kaposin (open reading frame K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming gene. J Virol 72:4980–8.

    PubMed  CAS  Google Scholar 

  312. Muralidhar, S., G. Veytsmann, B. Chandran, D. Ablashi, J. Doniger, and L. J. Rosenthal. 2000. Characterization of the human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) oncogene, kaposin (ORF K12). J Clin Virol 16:203–13.

    PubMed  CAS  Google Scholar 

  313. Murdoch, C., and A. Finn. 2000. Chemokine receptors and their role in inflammation and infectious diseases. Blood 95:3032–43.

    PubMed  CAS  Google Scholar 

  314. Murdoch, C., and A. Finn. 2000. Chemokine receptors and their role in vascular biology. J Vasc Res 37:1–7.

    PubMed  CAS  Google Scholar 

  315. Muromoto, R., K. Okabe, M. Fujimuro, K. Sugiyama, H. Yokosawa, T. Seya, and T. Matsuda. 2006. Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA. FEBS Lett 580:93–8.

    PubMed  CAS  Google Scholar 

  316. Nair, V., and M. Zavolan. 2006. Virus-encoded microRNAs: novel regulators of gene expression. Trends Microbiol 14:169–75.

    PubMed  CAS  Google Scholar 

  317. Nakamura, H., M. Li, J. Zarycki, and J. U. Jung. 2001. Inhibition of p53 tumor suppressor by viral interferon regulatory factor. J Virol 75:7572–82.

    PubMed  CAS  Google Scholar 

  318. Nakamura, H., M. Lu, Y. Gwack, J. Souvlis, S. L. Zeichner, and J. U. Jung. 2003. Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator. J Virol 77:4205–20.

    PubMed  CAS  Google Scholar 

  319. Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci USA 95:3537–42.

    PubMed  CAS  Google Scholar 

  320. Naranatt, P. P., S. M. Akula, C.A. Zien, H. H. Krishnan, and B. Chandran. 2003. Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity. J Virol 77:1524–39.

    PubMed  CAS  Google Scholar 

  321. Naranatt, P. P., H. H. Krishnan, M. S. Smith, and B. Chandran. 2005. Kaposi's sarcoma-associated herpesvirus modulates microtubule dynamics via RhoA-GTP-diaphanous 2 signaling and utilizes the dynein motors to deliver its DNA to the nucleus. J Virol 79:1191–206.

    PubMed  CAS  Google Scholar 

  322. Naranatt, P. P., H. H. Krishnan, S. R. Svojanovsky, C. Bloomer, S. Mathur, and B. Chandran. 2004. Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection. Cancer Res 64:72–84.

    PubMed  CAS  Google Scholar 

  323. Nealon, K., W. W. Newcomb, T. R. Pray, C. S. Craik, J. C. Brown, and D. H. Kedes. 2001. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. J Virol 75:2866–78.

    PubMed  CAS  Google Scholar 

  324. Nicholas, J., V. R. Ruvolo, W. H. Burns, G. Sandford, X. Wan, D. Ciufo, S. B. Hendrickson, H. G. Guo, G. S. Hayward, and M. S. Reitz. 1997. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nat Med 3:287–92.

    PubMed  CAS  Google Scholar 

  325. Nocera, A., M. Corbellino, U. Valente, S. Barocci, F. Torre, R. De Palma, A. Sementa, G. B. Traverso, A. Icardi, I. Fontana, V. Arcuri, F. Poli, P. Cagetti, P. Moore, and C. Parravicini. 1998. Posttransplant human herpes virus 8 infection and seroconversion in a Kaposi's sarcoma affected kidney recipient transplanted from a human herpes virus 8 positive living related donor. Transplant Proc 30:2095–6.

    PubMed  CAS  Google Scholar 

  326. O'Brien, T. R., D. Kedes, D. Ganem, D. R. Macrae, P. S. Rosenberg, J. Molden, and J. J. Goedert. Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma. J Infect Dis 180:1010–7.

    Google Scholar 

  327. O'Leary, J. J., M. Kennedy, K. Luttich, V. Uhlmann, I. Silva, J. Russell, O. Sheils, M. Ring, M. Sweeney, C. Kenny, N. Bermingham, C. Martin, M. O'Donovan, D. Howells, S. Picton, and S. B. Lucas. 2000. Localization of HHV-8 in AIDS related lymphadenopathy. Mol Pathol 53:43–7.

    PubMed  Google Scholar 

  328. Oettle, A. G. 1962. Geographical and racial differences in the frequency of Kaposi's sarcoma as evidence of environmental or genetic causes. Acta Unio Int Contra Cancrum 18:330–63.

    PubMed  CAS  Google Scholar 

  329. Offermann, M. K. 1999. Consideration of host-viral interactions in the pathogenesis of Kaposi's sarcoma. J Acquir Immune Defic Syndr 21(Suppl 1):S58–65.

    PubMed  CAS  Google Scholar 

  330. Ojala, P. M., M. Tiainen, P. Salven, T. Veikkola, E. Castanos-Velez, R. Sarid, P. Biberfeld, and T. P. Makela. 1999. Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6. Cancer Res 59:4984–9.

    PubMed  CAS  Google Scholar 

  331. Ojala, P. M., K. Yamamoto, E. Castanos-Velez, P. Biberfeld S. J., Korsmeyer, and T. P. Makela. 2000. The apoptotic v-cyclin–CDK6 complex phosphorylates and inactivates Bcl-2. Nat Cell Biol 2:819–25.

    PubMed  CAS  Google Scholar 

  332. Osborne, J., P. S. Moore, and Y. Chang. 1999. KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways. Hum Immunol 60:921–7.

    PubMed  CAS  Google Scholar 

  333. Pan, H., J. Xie, F. Ye, S-J. Gao. Modulation of Kaposi's sarcoma -associated herpesvirus infection and replication by MEK/ERK, JNK, and p38 multiple mitogen-activated protein kinase pathways during primary infection. J Virol 80:5371–82.

    Google Scholar 

  334. Pan, H., F. Zhou, and S. J. Gao. 2004. Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cells. Cancer Res 64:4064–8.

    PubMed  CAS  Google Scholar 

  335. Pan, H. Y., Y. J. Zhang, X. P. Wang, J. H. Deng, F. C. Zhou, and S. J. Gao. 2003. Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol 77:9758–68.

    PubMed  CAS  Google Scholar 

  336. Parravicini, C., B. Chandran, M. Corbellino, E. Berti, M. Paulli, P. S. Moore, and Y. Chang. 2000. Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol 156: 743–9.

    PubMed  CAS  Google Scholar 

  337. Parravicini, C., S. J. Olsen, M. Capra, F. Poli, G. Sirchia, S. J. Gao, E. Berti, A. Nocera, E. Rossi, G. Bestetti, M. Pizzuto, M. Galli, M. Moroni, P. S. Moore, and M. Corbellino. 1997. Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients. Blood 90:2826–9.

    Google Scholar 

  338. Parsons, C. H., B. Szomju, and D. H. Kedes. 2004. Susceptibility of human fetal mesenchymal stem cells to Kaposi's sarcoma-associated herpesvirus. Blood 104:2736–8.

    PubMed  CAS  Google Scholar 

  339. Pati, S., M. Cavrois, H. G. Guo, J. S. Foulke, Jr., J. Kim, R. A. Feldman, and M. Reitz. 2001. Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J Virol 75:8660–73.

    PubMed  CAS  Google Scholar 

  340. Pearce, M., S. Matsumura, and A. C. Wilson. 2005. Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter. J Virol 79:14457–64.

    PubMed  CAS  Google Scholar 

  341. Pertel, P. E. 2002. Human herpesvirus 8 glycoprotein B (gB), gH, and gL can mediate cell fusion. J Virol 76:4390–400.

    PubMed  CAS  Google Scholar 

  342. Pfeffer, S., A. Sewer, M. Lagos-Quintana, R. Sheridan, C. Sander, F. A. Grasser, L. F. van Dyk, C. K. Ho, S. Shuman, M. Chien, J. J. Russo, J. Ju, G. Randall, B. D. Lindenbach, C. M. Rice, V. Simon, D. D.Ho, M. Zavolan, and T. Tuschl. 2005. Identification of microRNAs of the herpesvirus family. Nat Methods 2:269–76.

    PubMed  CAS  Google Scholar 

  343. Picchio, G. R. E. Sabbe, R. J. Gulizia, M. McGrath, B. G. Herndier, and D. E. Mosier. 1997. The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft. Virology 238:22–9.

    PubMed  CAS  Google Scholar 

  344. Pine, R., T. Decker, D. S. Kessler, D. E. Levy, and J. E. Darnell, Jr. 1990. Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either. Mol Cell Biol 10:2448–57.

    PubMed  CAS  Google Scholar 

  345. Piolot, T., M. Tramier, M. Coppey, J. C. Nicolas, and V. Marechal. 2001. Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomes. J Virol 75:3948–59.

    PubMed  CAS  Google Scholar 

  346. Plow, E. F., T. A. Haas, L. Zhang, J. Loftus, and J. W. Smith. 2000. Ligand binding to integrins. J Biol Chem 275:21785–8.

    PubMed  CAS  Google Scholar 

  347. Polstra, A. M., M. Cornelissen, J. Goudsmit, and A. C. van der Kuyl. 2004. Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related Kaposi's sarcoma patients before and after diagnosis. J Med Virol 74:390–6.

    PubMed  CAS  Google Scholar 

  348. Popescu, N. C., D. B. Zimonjic, S. Leventon-Kriss, J. L. Bryant, Y. Lunardi-Iskandar, and R. C. Gallo. 1996. Deletion and translocation involving chromosome 3 (p14) in two tumorigenic Kaposi's sarcoma cell lines. J Natl Cancer Inst 88:450–5.

    PubMed  CAS  Google Scholar 

  349. Prakash, O., O. R. Swamy, X. Peng, Z. Y. Tang, L. Li, J. E. Larson, J. C. Cohen, J. Gill, G. Farr, S. Wang, and F. Samaniego. 2005. Activation of Src kinase Lyn by the Kaposi's sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis. Blood 105:3987–94.

    PubMed  CAS  Google Scholar 

  350. Pyakurel, P., F. Pak, A. R. Mwakigonja, E. Kaaya, T. Heiden, and P. Biberfeld. 2006. Lymphatic and vascular origin of Kaposi's sarcoma spindle cells during tumor development. Int J Cancer 119:1262–7.

    PubMed  CAS  Google Scholar 

  351. Qiang, W., J. M. Cahill, J. Liu, X. Kuang, N. Liu, V. L. Scofield, J. R. Voorhees, A. J. Reid, M. Yan, W. S. Lynn, and P. K. Wong. 2004. Activation of transcription factor Nrf-2 and its downstream targets in response to Maloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes. J Virol 78:11926–38.

    PubMed  CAS  Google Scholar 

  352. Radkov, S. A., P. Kellam, and C. Boshoff. The latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat Med 6:1121–7.

    Google Scholar 

  353. Rainbow, L., G. M. Platt, G. R. Simpson, R. Sarid, S. J. Gao, H. Stoiber, C. S. Herrington, P. S. Moore, and T. F. Schulz. 1997. The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol 71:5915–21.

    PubMed  CAS  Google Scholar 

  354. Rappocciolo, G., F. J. Jenkins, H. R. Hensler, P. Piazza, M. Jais, L. Borowski, S. C. Watkins, and C. R. Rinaldo, Jr. 2006. DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages. J Immunol 176:1741–9.

    PubMed  CAS  Google Scholar 

  355. Regamey, N., M. Tamm, M. Wernli, A. Witschi, G. Thiel, G. Cathomas, and P. Erb. 1998. Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. N Engl J Med 339:1358–63.

    PubMed  CAS  Google Scholar 

  356. Relloso, M., A. Puig-Kroger, O. M. Pello, J. L. Rodriguez-Fernandez, G. de la Rosa, N. Longo, J. Navarro, M. A. Munoz-Fernandez, P. Sanchez-Mateos, and A. L. Corbi. 2002. DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents. J Immunol 168:2634–43.

    PubMed  CAS  Google Scholar 

  357. Renne, R., D. Blackbourn, D. Whitby, J. Levy, and D. Ganem. Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol 72:5182–8.

    Google Scholar 

  358. Renne, R., D. Dittmer, D. Kedes, K. Schmidt, R. C. Desrosiers, P. A. Luciw, and D. Ganem. 2004. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SIV-positive and SIV-negative rhesus macaques. J Med Primatol 33:1–9.

    PubMed  CAS  Google Scholar 

  359. Renne, R., W. Zhong, B. Herndier, M. McGrath, N. Abbey, D. Kedes, and D. Ganem. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 2:342–6.

    PubMed  CAS  Google Scholar 

  360. Renwick, N., T. Halaby, G. J. Weverling, N. H. Dukers, G. R. Simpson, R. A. Coutinho, J. M. Lange, T. F. Schulz, and J. Goudsmit. Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi's sarcoma. AIDS 12:2481–8.

    Google Scholar 

  361. Rimessi, P., A. Bonaccorsi, M. Sturzl, M. Fabris, E. Brocca-Cofano, A. Caputo, G. Melucci-Vigo, M. Falchi, A. Cafaro, E. Cassai, B. Ensoli, and P. Monini. 2001. Transcription pattern of human herpesvirus 8 open reading frame K3 in primary effusion lymphoma and Kaposi's sarcoma. J Virol 75:7161–74.

    PubMed  CAS  Google Scholar 

  362. Rivas, C., A. E. Thlick, C. Parravicini, P. S. Moore, and Y. Chang. 2001. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol 75:429–38.

    PubMed  CAS  Google Scholar 

  363. Roan, F., N. Inoue, and M. K. Offermann. 2002. Activation of cellular and heterologous promoters by the human herpesvirus 8 replication and transcription activator. Virology 301:293–3040.

    PubMed  CAS  Google Scholar 

  364. Roan, F., J. C. Zimring, S. Goodbourn., and M. K. Offermann. 1999. Transcriptional activation by the human herpesvirus-8-encoded interferon regulatory factor. J Gen Virol 80(Pt 8):2205–9.

    PubMed  CAS  Google Scholar 

  365. Robles, R., D. Lugo, L. Gee, and M. A. Jacobson. 1999. Effect of antiviral drugs used to treat cytomegalovirus end-organ disease on subsequent course of previously diagnosed Kaposi's sarcoma in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 20:34–8.

    PubMed  CAS  Google Scholar 

  366. Rose, T. M., K. B. Strand, E. R. Schultz, G. Schaefer, G. W. Rankin, Jr., M. E. Thouless, C. C. Tsai, and M. L. Bosch. 1997. Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. J Virol 71:4138–44.

    PubMed  CAS  Google Scholar 

  367. Russo, J. J., R. A. Bohenzky, M. C. Chien, J. Chen, M. Yan, D. Maddalena, J. P. Parry, D. Peruzzi, I. S. Edelman, Y. Chang, and P. S. Moore. 1996. Nucleotide sequence of the Kaposi's sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA 93:14862–7.

    PubMed  CAS  Google Scholar 

  368. Sadler, R., L. Wu, B. Forghani, R. Renne, W. Zhong, B. Herndier, and D. Ganem. 1999. A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. J Virol 73:5722–30.

    PubMed  CAS  Google Scholar 

  369. Sailer, A., K. Nagata, D. Naf, M. Aebi, and C. Weissmann. 1992. Interferon regulatory factor-1 (IRF-1) activates the synthetic IRF-1-responsive sequence (GAAAGT) 4 in Saccharomyces cerevisiae. Gene Expr 2:329–37.

    PubMed  CAS  Google Scholar 

  370. Sakakibara, S., K. Ueda, J. Chen, T. Okuno, and K. Yamanishi. 2001. Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated herpesvirus ORF50/Lyta gene expression. J Virol 75:6894–900.

    PubMed  CAS  Google Scholar 

  371. Sakakibara, S., K. Ueda, K. Nishimura, E. Do, E. Ohsaki, T. Okuno, and K. Yamanishi. 2004. Accumulation of heterochromatin components on the terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus mediated by the latency-associated nuclear antigen. J Virol 78:7299–310.

    PubMed  CAS  Google Scholar 

  372. Samaniego, F., P. D. Markham, R. C. Gallo, and B. Ensoli. 1995. Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice. J Immunol 154:3582–92.

    PubMed  CAS  Google Scholar 

  373. Samaniego, F., D. Young, C. Grimes, V. Prospero, M. Christofidou-Solomidou, H. M. DeLisser, O. Prakash, A. A. Sahin, and S. Wang. 2002. Vascular endothelial growth factor and Kaposi's sarcoma cells in human skin grafts. Cell Growth Differ 13:387–95.

    PubMed  CAS  Google Scholar 

  374. Samols, M. A., J. Hu, R. L. Skalsky, and R. Renne. 2005. Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. J Virol 79:9301–5.

    PubMed  CAS  Google Scholar 

  375. Sanchez, D. J., J. E. Gumperz, and D. Ganem. 2005. Regulation of CD1d expression and function by a herpesvirus infection. J Clin Invest 115:1369–78.

    PubMed  CAS  Google Scholar 

  376. Sarek, G., A. Jarviluoma, and P. M. Ojala. 2006. KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas. Blood 107:725–32.

    PubMed  CAS  Google Scholar 

  377. Sarid, R., O. Flore, R. A. Bohenzky, Y. Chang, and P. S. Moore. 1998. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J Virol 72:1005–12.

    PubMed  CAS  Google Scholar 

  378. Sarid, R., T. Sato, R. A. Bohenzky, J. J. Russo, and Y. Chang. Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nat Med 3:293–8.

    Google Scholar 

  379. Sasaki, H., H. Sato, K. Kuriyama-Matsumura, K. Sato, K. Maebara, H. Wang, M. Tamba, K. Itoh, M. Yamamoto, and S. Bannai. 2002. Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. J Biol Chem 277:44765–71.

    PubMed  CAS  Google Scholar 

  380. Sastry, S. K., and K. Burridge. 2000. Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res 261:25–36.

    PubMed  CAS  Google Scholar 

  381. Scadden, D. T. 2003. AIDS-related malignancies. Annu Rev Med 54:285–303.

    PubMed  CAS  Google Scholar 

  382. Schaller, M. D. 2001. Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta 1540:1–21.

    PubMed  CAS  Google Scholar 

  383. Schalling, M., M. Ekman, E. E. Kaaya, A. Linde, and P. Biberfeld. 1995. A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. Nat Med 1:707–8.

    PubMed  CAS  Google Scholar 

  384. Schulz, T. F. 2006. The pleiotropic effects of Kaposi's sarcoma herpesvirus. J Pathol 208:187–98.

    PubMed  CAS  Google Scholar 

  385. Schwam, D. R., R. L. Luciano, S. S. Mahajan, L. Wong, and A. C. Wilson. 2000. Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies. J Virol 74:8532–40.

    PubMed  CAS  Google Scholar 

  386. Schwarz, M., and P. M. Murphy. 2001. Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor constitutively activates NF-kappa B and induces proinflammatory cytokine and chemokine production via a C-terminal signaling determinant. J Immunol 167:505–13.

    PubMed  CAS  Google Scholar 

  387. Seaman, W. T., D. Ye, R. X. Wang, E. E. Hale, M. Weisse, and E. B. Quinlivan. 1999. Gene expression from the ORF50/K8 region of Kaposi's sarcoma-associated herpesvirus. Virology 263:436–49.

    PubMed  CAS  Google Scholar 

  388. Searles, R. P., E. P. Bergquam, M. K. Axthelm, and S. W. Wong. 1999. Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J Virol 73:3040–53.

    PubMed  CAS  Google Scholar 

  389. Seo, T., D. Lee, B. Lee, J. H. Chung, and J. Choe. 2000. Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) binds to, and inhibits transactivation of, CREB-binding protein. Biochem Biophys Res Commun 270:23–7.

    PubMed  CAS  Google Scholar 

  390. Seo, T., D. Lee, Y. S. Shim, J. E. Angell, N. V. Chidambaram, D. V. Kalvakolanu, and J. Choe. 2002. Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death. J Virol 76:8797–807.

    PubMed  CAS  Google Scholar 

  391. Seo, T., J. Park, D. Lee, S. G. Hwang, and J. Choe. 2001. Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus binds to p53 and represses p53-dependent transcription and apoptosis. J Virol 75:6193–8.

    PubMed  CAS  Google Scholar 

  392. Sgarbanti, M., M. Arguello. B. R. tenOever, A. Battistini, R. Lin, and J. Hiscott. A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions. Oncogene 23:5770–80.

    Google Scholar 

  393. Sharma-Walia, N., H. H. Krishnan, P. P. Naranatt, L. Zeng, M. S. Smith, and B. Chandran. 2005. RK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection. J Virol 79:10308–29.

    PubMed  CAS  Google Scholar 

  394. Sharma-Walia, N., P. P. Naranatt, H. H. Krishnan, L. Zeng, and B. Chandran. 2004. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-phosphatidylinositol 3-kinase-rho GTPase signal pathways and cytoskeletal rearrangements. J Virol 78:4207–23.

    PubMed  CAS  Google Scholar 

  395. Sharp, T. V., H. W. Wang, A. Koumi, D. Hollyman, Y. Endo, H. Ye, M. Q. Du, and C. Boshoff. 2002. K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function. J Virol 76:802–16.

    PubMed  CAS  Google Scholar 

  396. Shepard, L. W., M. Yang, P. Xie, D. D. Browning, T. Voyno-Yasenetskaya, T. Kozasa, R. D. and Ye. 2001. Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha13 and RhoA. J Biol Chem 276:45979–87.

    PubMed  CAS  Google Scholar 

  397. Shin, Y. C., H. Nakamura, X. Liang, P. Feng, H. Chang, T. F. Kowalik, and J. U. Jung. 2006. Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. J Virol 80:2257–66.

    PubMed  CAS  Google Scholar 

  398. Shinohara, H., M. Fukushi, M. Higuchi, M. Oie, O. Hoshi, T. Ushiki, J. Hayashi, and M. Fujii. 2002. Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1. J Virol 76:12917–24.

    PubMed  CAS  Google Scholar 

  399. Si, H., and E. S. Robertson. 2006. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 function. J Virol 80:697–709.

    PubMed  CAS  Google Scholar 

  400. Sieczkarski, S. B., and G. R. Whittaker. 2002. Dissecting virus entry via endocytosis. J Gen Virol 83:1535–45.

    PubMed  CAS  Google Scholar 

  401. Siegal, F. P., C. Lopez, G. S. Hammer, A. E. Brown, S. J. Kornfeld, J. Gold, J. Hassett, S. Z. Hirschman, C. Cunningham-Rundles, B. R. Adelsberg, and etal. 1981. Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med 305:1439–44.

    PubMed  CAS  Google Scholar 

  402. Simonart, T., C. Degraef, M. Heenen, P. Hermans, J. P. Van Vooren, and J. C. Noel. 2002. Expression of the fibroblast/macrophage marker 1B10 by spindle cells in Kaposi's sarcoma lesions and by Kaposi's sarcoma-derived tumor cells. J Cutan Pathol 29:72–8.

    PubMed  Google Scholar 

  403. Simpson, G. R., T. F. Schulz, D. Whitby, P. M. Cook, C. Boshoff, L. Rainbow, M. R. Howard, S. J. Gao, R. A. Bohenzky, P. Simmonds, C. Lee, A. de Ruiter, A. Hatzakis, R. S. Tedder, I. V. Weller, R. A. Weiss, and P. S. Moore. 1996. Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 348:1133–8.

    Google Scholar 

  404. Smit, M. J., D. Verzijl, P. Casarosa, M. Navis, H. Timmerman, and R. Leurs. 2002. Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor ORF74 constitutively activates p44/p42 MAPK and Akt via G(i) and phospholipase C-dependent signaling pathways. J Virol 76:1744–52.

    PubMed  CAS  Google Scholar 

  405. Sodhi, A., S. Montaner, and J. S. Gutkind. 2004. Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis? Faseb J 18:422–7.

    PubMed  CAS  Google Scholar 

  406. Sodhi, A., S. Montaner, V. Patel, J. J. Gomez-Roman, Y. Li, E. A. Sausville, E. T. Sawai, and J. S. Gutkind. 2004. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci USA 101:4821–6.

    PubMed  CAS  Google Scholar 

  407. Sodhi, A., S. Montaner, V. Patel, M. Zohar, C. Bais, E. A. Mesri, and J. S. Gutkind. 2000. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Cancer Res 60:4873–80.

    PubMed  CAS  Google Scholar 

  408. Soilleux, E. J., L. S. Morris, B. Lee, S. Pohlmann, J. Trowsdale, R. W. Doms, and N. Coleman. 2001. Placental expression of DC-SIGN may mediate intrauterine vertical transmission of HIV. J Pathol 195:586–92.

    PubMed  CAS  Google Scholar 

  409. Soilleux, E. J., L. S. Morris, G. Leslie, J. Chehimi, Q. Luo, E. Levroney, J. Trowsdale, L. J. Montaner, R. W. Doms, D. Weissman, N. Coleman, and B. Lee. 2002. Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations insitu and invitro. J Leukoc Biol 71:445–57.

    PubMed  CAS  Google Scholar 

  410. Soilleux, E. J., L. S. Morris, S. Rushbrook, B. Lee, and N. Coleman. 2002. Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity. Hum Pathol 33:652–9.

    PubMed  CAS  Google Scholar 

  411. Soilleux, E. J., L. S. Morris, J. Trowsdale, N. Coleman, and J. J. Boyle. 2002. Human atherosclerotic plaques express DC-SIGN, a novel protein found on dendritic cells and macrophages. J Pathol 198:511–6.

    PubMed  CAS  Google Scholar 

  412. Song, J., T. Ohkura, M. Sugimoto, Y. Mori, R. Inagi, K. Yamanishi, K. Yoshizaki, and N. Nishimoto. 2002. Human interleukin-6 induces human herpesvirus-8 replication in a body cavity-based lymphoma cell line. J Med Virol 68:404–11.

    PubMed  CAS  Google Scholar 

  413. Song, M. J., H. Deng, and R. Sun. 2003. Comparative study of regulation of RTA-responsive genes in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J Virol 77:9451–62.

    PubMed  CAS  Google Scholar 

  414. Song, M. J., X. Li, H. J. Brown, and R. Sun. 2002. Characterization of interactions between RTA and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J Virol 76:5000–13.

    PubMed  CAS  Google Scholar 

  415. Soulier, J., L. Grollet, E. Oksenhendler, P. Cacoub, D. Cazals-Hatem, P. Babinet, M. F. d'Agay, J. P. Clauvel, M. Raphael, L. Degos, and etal. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86:1276–80.

    PubMed  CAS  Google Scholar 

  416. Spear, P. G., and R. Longnecker. 2003. Herpesvirus entry: an update. J Virol 77:10179–85.

    PubMed  CAS  Google Scholar 

  417. Spiller, O. B., D. J. Blackbourn, L. Mark, D. G. Proctor, and A. M. Blom. 2003. Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. J Biol Chem 278:9283–9.

    PubMed  CAS  Google Scholar 

  418. Spiller, O. B., L. Mark, C. E. Blue, D. G. Proctor, J. A. Aitken, A. M. Blom, and D. J. Blackbourn. 2006. Dissecting the regions of virion-associated Kaposi's sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding. J Virol 80:4068–78.

    PubMed  CAS  Google Scholar 

  419. Spiller, O. B., M. Robinson, E. O'Donnell, S. Milligan, B. P. Morgan, A. J. Davison, and D. J. Blackbourn. 2003. Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. J Virol 77:592–9.

    PubMed  CAS  Google Scholar 

  420. Staskus, K. A., W. Zhong, K. Gebhard, B. Herndier, H. Wang, R. Renne, J. Beneke, J. Pudney, D. J. Anderson, D. Ganem, and A. T. Haase. 1997. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol 71:715–9.

    PubMed  CAS  Google Scholar 

  421. Staudt, M. R., and D. P. Dittmer. 2006. Promoter switching allows simultaneous transcription of LANA and K14/vGPCR of Kaposi's sarcoma-associated herpesvirus. Virology 350:192–205.

    PubMed  CAS  Google Scholar 

  422. Staudt, M. R., and D. P. Dittmer. 2003. Viral latent proteins as targets for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) induced lymphoma. Curr Drug Targets Infect Disord 3:129–35.

    PubMed  CAS  Google Scholar 

  423. Stedman, W., Z. Deng, F. Lu, and P. M. Lieberman. 2004. ORC, MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication origin. J Virol 78:12566–75.

    PubMed  CAS  Google Scholar 

  424. Sternbach, G., and J. Varon. 1995. Moritz Kaposi: idiopathic pigmented sarcoma of the skin. J Emerg Med 13:671–4.

    PubMed  CAS  Google Scholar 

  425. Stine, J. T., C. Wood, M. Hill, A. Epp, C. J. Raport, V. L. Schweickart, Y. Endo, T. Sasaki, G. Simmons, C. Boshoff, P. Clapham, Y. Chang, P. Moore, P. W. Gray, and D. Chantry, D. 2000. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood 95:1151–7.

    Google Scholar 

  426. Sturzl, M., C. Hohenadl, C. Zietz, E. Castanos-Velez, A. Wunderlich, G. Ascherl, P. Biberfeld, P., Monini, J. Browning, and B. Ensoli. 1999. Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells. J Natl Cancer Inst 91:1725–33.

    PubMed  CAS  Google Scholar 

  427. Sturzl, M., A. Wunderlich, G. Ascherl, C. Hohenadl, P. Monini, C. Zietz, P. J. Browning, F. Neipel, P. Biberfeld, and B. Ensoli. 1999. Human herpesvirus-8 (HHV-8) gene expression in Kaposi's sarcoma (KS) primary lesions: an insitu hybridization study. Leukemia 13(Suppl 1):S110–2.

    PubMed  Google Scholar 

  428. Sturzl, M., C. Zietz, P. Monini, and B. Ensoli. 2001. Human herpesvirus-8 and Kaposi's sarcoma: relationship with the multistep concept of tumorigenesis. Adv Cancer Res 81:125–59.

    PubMed  CAS  Google Scholar 

  429. Sun, Q., S. Zachariah, and P. M. Chaudhary. 2003. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem 278:52437–45.

    PubMed  CAS  Google Scholar 

  430. Sun, R., S. F. Lin, L. Gradoville, Y. Yuan, F. Zhu, and G. Miller. 1998. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci USA 95:10866–71.

    PubMed  CAS  Google Scholar 

  431. Sun, R., S. F. Lin, K. Staskus, L. Gradoville, E. Grogan, A. Haase, and G. Miller. 1999. Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. J Virol 73:2232–42.

    PubMed  CAS  Google Scholar 

  432. Swanton, C., D. J. Mann, B. Fleckenstein, F. Neipel, G. Peters, and N. Jones. Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins. Nature 390:184–7.

    Google Scholar 

  433. Szekely, L., C. Kiss, K. Mattsson, E. Kashuba, K. Pokrovskaja, A. Juhasz, P. Holmvall, and G. Klein. 1999. Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin-associated nuclear bodies. J Gen Virol 80(Pt 11):2889–900.

    PubMed  CAS  Google Scholar 

  434. Talbot, S. J., R. A. Weiss, P. Kellam, and C. Boshoff. 1999. Transcriptional analysis of human herpesvirus-8 open reading frames 71, 72, 73, K14, and 74 in a primary effusion lymphoma cell line. Virology 257:84–94.

    PubMed  CAS  Google Scholar 

  435. Tamura, T., M. Ishihara, M. S. Lamphier, N. Tanaka, I. Oishi, S. Aizawa, T. Matsuyama, T. W. Mak, S. Taki, and T. Taniguchi. 1995. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376:596–9.

    PubMed  CAS  Google Scholar 

  436. Tanaka, N., M. Ishihara, M. S. Lamphier, H. Nozawa, T. Matsuyama, T. W. Mak, S. Aizawa, T. Tokino, M. Oren, and T. Taniguchi. 1996. Cooperation of the tumor suppressors IRF-1 and p53 in response to DNA damage. Nature 382:816–8.

    PubMed  CAS  Google Scholar 

  437. Tanaka, N., M. Ishihara, and T. Taniguchi. 1994. Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1. Cancer Lett 83:191–6.

    PubMed  CAS  Google Scholar 

  438. Tang, J., G. M. Gordon, M. G. Muller, M. Dahiya, and K. E. Foreman. 2003. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induces expression of the helix-loop-helix protein Id-1 in human endothelial cells. J Virol 77:5975–84.

    PubMed  CAS  Google Scholar 

  439. Tang, S., and Z. M. Zheng. 2002. Kaposi's sarcoma-associated herpesvirus K8 exon 3 contains three 5¢-splice sites and harbors a K8.1 transcription start site. J Biol Chem 277:14547–56.

    PubMed  CAS  Google Scholar 

  440. Taylor, K. R., and R. L. Gallo. 2006. Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation. Faseb J 20:9–22.

    PubMed  CAS  Google Scholar 

  441. Tetsuka, T., M. Higuchi, M. Fukushi, A. Watanabe, S. Takizawa, M. Oie, F. Gejyo, and M. Fujii. 2004. Visualization of a functional KSHV episome-maintenance protein LANA in living cells. Virus Genes 29:175–82.

    PubMed  CAS  Google Scholar 

  442. Tomkowicz, B., S. P. Singh, M. Cartas, and A. Srinivasan. 2002. Human herpesvirus-8 encoded Kaposin: subcellular localization using immunofluorescence and biochemical approaches. DNA Cell Biol 21:151–62.

    PubMed  CAS  Google Scholar 

  443. Turville, S. G., P. U. Cameron, A. Handley, G. Lin, S. Pohlmann, R. W. Doms, and A. L. Cunningham. 2002. Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol 3:975–83.

    PubMed  CAS  Google Scholar 

  444. Uccini, S., L. P. Ruco, F. Monardo, A. Stoppacciaro, E. Dejana, I. L. La Parola, D. Cerimele, and C. D. Baroni. 1994. Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells. J Pathol 173:23–31.

    PubMed  CAS  Google Scholar 

  445. Ueda, K., K. Ishikawa, K. Nishimura, S. Sakakibara, E. Do, and K. Yamanishi. 2002. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) replication and transcription factor activates the K9 (vIRF) gene through two distinct cis elements by a non-DNA-binding mechanism. J Virol 76:12044–54.

    PubMed  CAS  Google Scholar 

  446. Verma, S. C., S. Borah, and E. S. Robertson. 2004. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1. J Virol 78:10348–59.

    PubMed  CAS  Google Scholar 

  447. Verma, S. C., T. Choudhuri, R. Kaul, and E. S. Robertson. 2006. Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus interacts with origin recognition complexes at the LANA binding sequence within the terminal repeats. J Virol 80:2243–56.

    PubMed  CAS  Google Scholar 

  448. Verma, S. C., K. Lan, T. Choudhuri, and E. S. Robertson. 2006. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen modulates K1 expression through its cis-acting elements within the terminal repeats. J Virol 80:3445–58.

    PubMed  CAS  Google Scholar 

  449. Verschuren, E. W., N. Jones, and G. I. Evan. 2004. The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. J Gen Virol 85:1347–61.

    PubMed  CAS  Google Scholar 

  450. Verschuren, E. W., J. Klefstrom, G. I. Evan, and N. Jones. 2002. The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss invitro and invivo. Cancer Cell 2:229–41.

    PubMed  CAS  Google Scholar 

  451. Vieira, J., P. O'Hearn, L. Kimball, B. Chandran, and L. Corey. 2001. Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. J Virol 75:1378–86.

    PubMed  CAS  Google Scholar 

  452. Viejo-Borbolla, A., M. Ottinger, E. Bruning, A. Burger, R. Konig, E. Kati, J. A. Sheldon, and T. F. Schulz. 2005. Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1. J Virol 79:13618–29.

    PubMed  CAS  Google Scholar 

  453. Wan, X., H. Wang, and J. Nicholas. 1999. Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6. J Virol 73:8268–78.

    PubMed  CAS  Google Scholar 

  454. Wang, F. Z., S. M. Akula, N. P. Pramod, L. Zeng, and B. Chandran. Human herpesvirus 8 envelope glycoprotein K8.1A interaction with the target cells involves heparan sulfate. J Virol 75:7517–27.

    Google Scholar 

  455. Wang, F. Z., S. M. Akula, N. Sharma-Walia, L. Zeng, and B. Chandran. 2003. Human herpesvirus 8 envelope glycoprotein B mediates cell adhesion via its RGD sequence. J Virol 77:3131–47.

    PubMed  CAS  Google Scholar 

  456. Wang, H. W., T. V. Sharp, A. Koumi, G. Koentges, and C. Boshoff. 2002. Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin. EMBO J 21:2602–15.

    PubMed  CAS  Google Scholar 

  457. Wang, H. W., M. W. Trotter, D. Lagos, D. Bourboulia, S. Henderson, T. Makinen, S. Elliman, A. M. Flanagan, K. Alitalo, and C. Boshoff. 2004. Kaposi's sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi's sarcoma. Nat Genet 36:687–93.

    PubMed  CAS  Google Scholar 

  458. Wang, J., J. Zhang, L. Zhang, W. Harrington, Jr., J. T. West, and C. Wood. 2005. Modulation of human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus replication and transcription activator transactivation by interferon regulatory factor 7. J Virol 79:2420–31.

    PubMed  CAS  Google Scholar 

  459. Wang, J. F., X. Zhang, and J. E. Groopman. 2004. Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress. J Biol Chem 279:27088–97.

    PubMed  CAS  Google Scholar 

  460. Wang, L., D. P. Dittmer, C. C. Tomlinson, F. D. Fakhari, and B. Damania. 2006. Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. Cancer Res 66:3658–66.

    PubMed  CAS  Google Scholar 

  461. Wang, L., N. Wakisaka, C. C. Tomlinson, S. M. DeWire, S. Krall, J. S. Pagano, and B. Damania. The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors. Cancer Res 64:2774–81.

    Google Scholar 

  462. Wang, S., S. Liu, M. H. Wu, Y. Geng, and C. Wood. 2001. Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activation. J Virol 75:11961–73.

    PubMed  CAS  Google Scholar 

  463. Wang, S. E., F. Y. Wu, H. Chen, M. Shamay, Q. Zheng, and G. S. Hayward. 2004. Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. J Virol 78:4248–67.

    PubMed  CAS  Google Scholar 

  464. Wang, S. E., F. Y. Wu, M. Fujimuro, J. Zong, S. D. Hayward, and G. S. Hayward. 2003. Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma- associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP. J Virol 77:600–23.

    PubMed  CAS  Google Scholar 

  465. Wang, X. P., and S. J. Gao. 2003. Auto-activation of the transforming viral interferon regulatory factor encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). J Gen Virol 84:329–36.

    PubMed  CAS  Google Scholar 

  466. Wang, X. P., Y. J. Zhang, J. H. Deng, H. Y. Pan, F. C. Zhou, and S. J. Gao. 2002. Transcriptional regulation of Kaposi's sarcoma-associated herpesvirus-encoded oncogene viral interferon regulatory factor by a novel transcriptional silencer, Tis. J Biol Chem 277:12023–31.

    PubMed  CAS  Google Scholar 

  467. Wang, X. P., Y. J. Zhang, J. H. Deng, H. Y. Pan, F. C. Zhou, E. A. Montalvo, and S. J. Gao. 2001. Characterization of the promoter region of the viral interferon regulatory factor encoded by Kaposi's sarcoma-associated herpesvirus. Oncogene 20:523–30.

    PubMed  CAS  Google Scholar 

  468. Watanabe, T., M. Sugaya, A. M.Atkins, E. A. Aquilino, A. Yang, D. L. Borris, J. Brady, and A. Blauvelt. 2003. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen prolongs the life span of primary human umbilical vein endothelial cells. J Virol 77:6188–96.

    PubMed  CAS  Google Scholar 

  469. Weindel, K., D. Marme, and H. A. Weich. 1992. AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor. Biochem Biophys Res Commun 183:1167–74.

    PubMed  CAS  Google Scholar 

  470. Weisz, A., S. Kirchhoff, and B. Z. Levi. 1994. IFN consensus sequence binding protein (ICSBP) is a conditional repressor of IFN inducible promoters. Int Immunol 6:1125–31.

    PubMed  CAS  Google Scholar 

  471. Weisz, A., P. Marx, R. Sharf, E. Appella, P. H. Driggers, K. Ozato, and B. Z. Levi. 1992. Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. J Biol Chem 267:25589–96.

    PubMed  CAS  Google Scholar 

  472. Weninger, W., T. A. Partanen, S. Breiteneder-Geleff, C. Mayer, H. Kowalski, M. Mildner, J. Pammer, M. Sturzl, D. Kerjaschki, K. Alitalo, and E. Tschachler. 1999. Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells. Lab Invest 79:243–51.

    PubMed  CAS  Google Scholar 

  473. Weninger, W., M. Rendl, J. Pammer, M. Mildner, W. Tschugguel, C. Schneeberger, M. Sturzl, and E. Tschachler. 1998. Nitric oxide synthases in Kaposi's sarcoma are expressed predominantly by vessels and tissue macrophages. Lab Invest 78:949–55.

    PubMed  CAS  Google Scholar 

  474. West, J. T., and C. Wood. 2003. The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression. Oncogene 22:5150–63.

    PubMed  CAS  Google Scholar 

  475. Widmer, I., M. Wernli, F. Bachmann, F. Gudat, G. Cathomas, and P. Erb. 2002. Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions. J Virol 76:2551–6.

    PubMed  CAS  Google Scholar 

  476. Wong, E. L., and B. Damania, B. 2006. Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus K15 gene. J Virol 80:1385–92.

    Google Scholar 

  477. Wong, S. W., E. P. Bergquam, R. M. Swanson, F. W. Lee, S. M. Shiigi, N. A. Avery, J. W Fanton, and M. K. Axthelm. 1999. Induction of B cell hyperplasia in simian immunodeficiency virus-infected rhesus macaques with the simian homologue of Kaposi's sarcoma-associated herpesvirus. J Exp Med 190:827–40.

    PubMed  CAS  Google Scholar 

  478. Wood, C., and W. Harrington Jr. 2005. AIDS and associated malignancies. Cell Res 15:947–52.

    PubMed  Google Scholar 

  479. Wu, C., A. E. Chung, and J. A. McDonald. 1995. A novel role for alpha 3 beta 1 integrins in extracellular matrix assembly. J Cell Sci 108(Pt 6):2511–23.

    PubMed  CAS  Google Scholar 

  480. Wu, F. Y., Q. Q. Tang, H. Chen, C. ApRhys, C. Farrell, J. Chen, M. Fujimuro, M. D. Lane, and G. S. Hayward. 2002. Lytic replication-associated protein (RAP) encoded by Kaposi's sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha. Proc Natl Acad Sci USA 99:10683–8.

    PubMed  CAS  Google Scholar 

  481. Wu, L., P. Lo, X. Yu, J. K. Stoops, B. Forghani, and Z. H. Zhou. 2000. Three-dimensional structure of the human herpesvirus 8 capsid. J Virol 74:9646–54.

    PubMed  CAS  Google Scholar 

  482. Wu, T. T., E. J. Usherwood, J. P. Stewart, A. A. Nash, and R. Sun. 2000. Rta of murine gammaherpesvirus 68 reactivates the complete lytic cycle from latency. J Virol 74:3659–67.

    PubMed  CAS  Google Scholar 

  483. Wu, W., J. Vieira, N. Fiore, P. Banerjee, M. Sieburg, R. Rochford, W. Harrington Jr., and G. Feuer. 2006. KSHV/HHV-8 infection of human hematopoietic progenitor (CD34+) cells: persistence of infection during hematopoiesis invitro and invivo. Blood.

    Google Scholar 

  484. Xie, J., H. Pan, S. Yoo, and S. J. Gao. 2005. Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways. J Virol 79:15027–37.

    PubMed  CAS  Google Scholar 

  485. Xu, Y., D. P. AuCoin, A. R. Huete, S. A. Cei, L. J. Hanson, and G. S. Pari. 2005. A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication. J Virol 79:3479–87.

    PubMed  CAS  Google Scholar 

  486. Yang, T. Y., S. C. Chen, M. W. Leach, D. Manfra, B. Homey, M. Wiekowski, L. Sullivan, C. H. Jenh, S. K. Narula, S. W. Chensue, and S. A. Lira. 2000. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma. J Exp Med 191:445–54.

    PubMed  CAS  Google Scholar 

  487. Ye, F. C., F. C. Zhou, S. M. Yoo, J. P. Xie, P. J. Browning, and S. J. Gao. Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence. J Virol 78:11121–9.

    Google Scholar 

  488. Ye, J., D. Shedd, and G. Miller. 2005. An Sp1 response element in the Kaposi's sarcoma-associated herpesvirus open reading frame 50 promoter mediates lytic cycle induction by butyrate. J Virol 79:1397–408.

    PubMed  CAS  Google Scholar 

  489. Yoo, S. M., F. C. Zhou, F. C. Ye, H. Y. Pan, and S. J. Gao. 2005. Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells. Virology 343:47–64.

    PubMed  CAS  Google Scholar 

  490. You, R. I., M. C. Chen, H. W. Wang, Y. C. Chou, C. H. Lin, and S. L. Hsieh. 2006. Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3. Cancer Res 66:3051–61.

    PubMed  CAS  Google Scholar 

  491. Yu, Y., S. E. Wang, and G. S. Hayward. 2005. The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity 22:59–70.

    PubMed  CAS  Google Scholar 

  492. Zala, C., C. Ochoa, A. Krolewiecki, P. Patterson, P. Cahn, R. I. Crawford, and J. S. Montaner. 2000. Highly active antiretroviral therapy does not protect against Kaposi's sarcoma in HIV-infected individuals. AIDS 14:2217–8.

    PubMed  CAS  Google Scholar 

  493. Zhang, J., J. Wang, C. Wood, D. Xu, and L. Zhang. 2005. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 replication and transcription activator regulates viral and cellular genes via interferon-stimulated response elements. J Virol 79:5640–52.

    PubMed  CAS  Google Scholar 

  494. Zhang, X., J. F. Wang, B. Chandran, K. Persaud, B. Pytowski, J. Fingeroth, and J. E. Groopman. 2005. Kaposi's sarcoma-associated herpesvirus activation of vascular endothelial growth factor receptor 3 alters endothelial function and enhances infection. J Biol Chem 280:26216–24.

    PubMed  CAS  Google Scholar 

  495. Zhang, Y. J., J. H. Deng, C. Rabkin, and S. J. Gao. 2000. Hot-spot variations of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen and application in genotyping by PCR-RFLP. J Gen Virol 81:2049–58.

    PubMed  CAS  Google Scholar 

  496. Zhang, Y. J., H. Y. Pan, and S. J. Gao. 2001. Reverse transcription slippage over the mRNA secondary structure of the LIP1 gene. Biotechniques 31:1286, 1288, 1290.

    Google Scholar 

  497. Zhong, W., H. Wang, B. Herndier, and D. Ganem. 1996. Restricted expression of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi's sarcoma. Proc Natl Acad Sci USA 93:6641–6.

    PubMed  CAS  Google Scholar 

  498. Zhou, F. C., Y. J. Zhang, J. H. Deng, X. P. Wang, H. Y. Pan, E. Hettler, and S. J. Gao. 2002. Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis. J Virol 76:6185–96.

    PubMed  CAS  Google Scholar 

  499. Zhu, F. X., J. M. Chong, L. Wu, and Y. Yuan. 2005. Virion proteins of Kaposi's sarcoma-associated herpesvirus. J Virol 79, 800–11 (2005).

    PubMed  CAS  Google Scholar 

  500. Zhu, F. X., T. Cusano, and Y. Yuan. 1999. Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus. J Virol 73:5556–67.

    PubMed  CAS  Google Scholar 

  501. Zhu, F. X., S. M. King, E. J. Smith, D. E. Levy, and Y. Yuan. 2002. A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Proc Natl Acad Sci USA 99:5573–8.

    PubMed  CAS  Google Scholar 

  502. Zhu, F. X., and Y. Yuan. 2003. The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions. J Virol 77:4221–30.

    PubMed  CAS  Google Scholar 

  503. Zimring, J. C., S. Goodbourn, and M. K. Offermann. 1998. Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription. J Virol 72:701–7.

    PubMed  CAS  Google Scholar 

  504. Zoeteweij, J. P., A. V. Moses, A. S. Rinderknecht, D. A. Davis, W. W. Overwijk, R. Yarchoan, J. M. Orenstein, and A. Blauvelt. 2001. Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi's sarcoma-associated herpesvirus. Blood 97:2374–80.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Tumor Virology Program, Children's Cancer Research Institute, Departments of Pediatrics, The University of Texas Health Science Center, San Antonio, TX

    Whitney Greene

  2. Tumor Virology Program, Children's Cancer Research Institute, Departments of Pediatrics, The University of Texas Health Science Center, San Antonio, TX

    Kurt Kuhne

  3. Tumor Virology Program, Children's Cancer Research Institute, Departments of Pediatrics, The University of Texas Health Science Center, San Antonio, TX

    Fengchun Ye

  4. Tumor Virology Program, Children's Cancer Research Institute, Departments of Pediatrics, The University of Texas Health Science Center, San Antonio, TX

    Jiguo Chen

  5. Tumor Virology Program, Children's Cancer Research Institute, Departments of Pediatrics, The University of Texas Health Science Center, San Antonio, TX

    Fuchun Zhou

  6. Tumor Virology Program, Children's Cancer Research Institute, Departments o, The University of Texas Health Science Center, San Antonio, TX

    Xiufeng Lei

  7. Tumor Virology Program, Children's Cancer Research Institute, Departments o, The University of Texas Health Science Center, San Antonio, TX

    Shou-Jiang Gao

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Greene, W. et al. (2007). Molecular Biology of KSHV in Relation to AIDS-Associated Oncogenesis. In: Meyers, C. (eds) Aids-Associated Viral Oncogenesis. Cancer Treatment and Research, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-46816-7_3

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