Abstract
Development of the vertebrate skeleton is a complex process involving genes that control a series of cellular events such as proliferation, migration, mesenchymal condensations and eventually differentiation into osteoblasts and chondrocytes1. For osteoblast differentiation, an intricate and highly regulated interplay of growth factors, receptors/co-receptors, specific extracellular milieu and transcription factors is required2. Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF- ) superfamily, are multifunctional growth factors critically involved in osteoblast differentiation. The BMP functions are exerted through their interaction with specific cell surface receptors, BMP type I and II receptors, leading to the regulation of specific BMP target genes. The signaling is regulated at numerous steps at extracellular, cell surface and intracellular levels3, 4.
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Mochida, Y., Parisuthiman, D., Yamauchi, M. (2006). Biglycan Is a Positive Modulator of BMP-2 Induced Osteoblast Differentiation. In: Fisher, J.P. (eds) Tissue Engineering. Advances in Experimental Medicine and Biology, vol 585. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34133-0_7
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DOI: https://doi.org/10.1007/978-0-387-34133-0_7
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