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From Amoeba to Macrophages: Exploring the Molecular Mechanisms of Legionella pneumophila Infection in Both Hosts

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Molecular Mechanisms in Legionella Pathogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 376))

Abstract

Legionella pneumophila is a Gram-negative bacterium and the causative agent of Legionnaires’ disease. It replicates within amoeba and infects accidentally human macrophages. Several similarities are seen in the L. pneumophila-infection cycle in both hosts, suggesting that the tools necessary for macrophage infection may have evolved during co-evolution of L. pneumophila and amoeba. The establishment of the Legionella-containing vacuole (LCV) within the host cytoplasm requires the remodeling of the LCV surface and the hijacking of vesicles and organelles. Then L. pneumophila replicates in a safe intracellular niche in amoeba and macrophages. In this review we will summarize the existing knowledge of the L. pneumophila infection cycle in both hosts at the molecular level and compare the factors involved within amoeba and macrophages. This knowledge will be discussed in the light of recent findings from the Acanthamoeba castellanii genome analyses suggesting the existence of a primitive immune-like system in amoeba.

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Acknowledgments

This work received financial support from the Institut Pasteur, the Centre National de la Recherche (CNRS), the Institut Carnot-Pasteur MI, the Fondation pour la Recherche Médicale (FRM) grant N° DEQ20120323697, the French region Ile-de-France (DIM Malinf) and the grant n°ANR-10-LABX-62-IBEID. M. Rolando is holder of a Roux contract financed by the Institut Pasteur.

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  1. Institut Pasteur, Biologie des Bactéries Intracellulaires and CNRS UMR, 3525, Paris, France

    Pedro Escoll, Monica Rolando, Laura Gomez-Valero & Carmen Buchrieser

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  1. Pedro Escoll
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  2. Monica Rolando
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  3. Laura Gomez-Valero
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Correspondence to Carmen Buchrieser .

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  1. Max von Pettenkofer Institute, Ludwig-Maximilians University München, Munich, Germany

    Hubert Hilbi

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Escoll, P., Rolando, M., Gomez-Valero, L., Buchrieser, C. (2013). From Amoeba to Macrophages: Exploring the Molecular Mechanisms of Legionella pneumophila Infection in Both Hosts. In: Hilbi, H. (eds) Molecular Mechanisms in Legionella Pathogenesis. Current Topics in Microbiology and Immunology, vol 376. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2013_351

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