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Simulated Moving Bed Chromatography (SMB) for Application in Bioseparation

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Book cover Modern Advances in Chromatography

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 76))

Abstract

Simulated Moving Bed (SMB) technology is of rising interest in the field of bioseparation. This is particularly due to its advantages such as reduction of solvent consumption, high productivity and final purities as well as low investment costs in comparison to eluent chromatography. SMB units can operate under high productivity overloaded conditions. This leads to nonlinear competitive adsorption behavior, which has to be accounted for when designing and optimizing new SMB separations. The so called “Triangle Theory”, which is briefly reviewed in this chapter, provides explicit criteria for the choice of the operating conditions of SMB units to achieve the prescribed separation of a mixture characterized by Langmuir, modified Langmuir and bi-Langmuir isotherms.

The application of the SMB-technique to the downstream processing of biotechnological products requires some specific changes to meet the special demands of bioproduct isolation. Some exemplary applications are given including separations of sugars, proteins,monoclonal antibodies, ionic molecules and optical isomers and for desalting.

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Authors and Affiliations

  1. Aventis Pharma Deutschland GmbH, Industriepark Hoechst, 65926, Frankfurt, Germany

    Sabine Imamoglu

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  1. Sabine Imamoglu
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  1. Laboratoire de Biotechnologie Chimique Institut de Sciences des Precédés Chimiques et Biologiques Faculté des Sciences de Base, Ecole Polytechnique Fédérate Lausanne, 1015, Lausanne, Switzerland

    Ruth Freitag

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© 2002 Springer-Verlag Berlin Heidelberg

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Imamoglu, S. (2002). Simulated Moving Bed Chromatography (SMB) for Application in Bioseparation. In: Freitag, R. (eds) Modern Advances in Chromatography. Advances in Biochemical Engineering/Biotechnology, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45345-8_6

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  • DOI: https://doi.org/10.1007/3-540-45345-8_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43042-1

  • Online ISBN: 978-3-540-45345-1

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