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Second and Third Generation Plague Vaccines

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Book cover The Genus Yersinia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 529))

Conclusion

A defined sub-unit vaccine against plague now seems to be feasible. The further development of this vaccine will be dependent on clinical trials with this vaccine. In parallel, there is good reason to believe that next-generation vaccines, will be given orally or intranasally.

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References

  • Anderson, G.W. Jr., Leary, S.E.C., Williamson, E.D., Titball, R.W., Welkos, S.L., Worsham, P.L. and Friedlander, A.M., 1996, Recombinant V antigen protects mice against pneumonic and bubonic caused by F1-capsule-positive and-negative strains of Yersinia pestis. Infect. Immun. 64: 4580–4585.

    CAS  PubMed  Google Scholar 

  • Andrews, G.P., Strachan, S.T., Benner, G.E., Sample, A.K., Anderson, G.W., Adamovicz, J.J., Welkos, S.L., Pullen, J.K., Friedlander, A.M., 1999, Protective efficacy of recombinant Yersinia outer proteins against bubonic plague caused by encapsulated and nonencapsulated Yersinia pestis. Infect. Immun. 67: 1533–1537.

    CAS  PubMed  Google Scholar 

  • Bartelloni, P.J., Marshall, J.D., Cavanaugh, D.C., 1973, Clinical and serological responses to plague vaccine. Mil. Med. 138: 720–722.

    CAS  PubMed  Google Scholar 

  • Carr, S., Miller, J., Leary, S.E.C., Bennett, A.M., Ho, A and Williamson, E.D., 1999, Expression of a recombinant form of the V antigen of Yersinia pestis using three different expression systems. Vaccine 18: 153–159.

    Article  CAS  PubMed  Google Scholar 

  • Du, Y., Rosqvist, R., Forsberg, A., 2002, Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis. Infect. Immun. 70: 1453–1460.

    Article  CAS  PubMed  Google Scholar 

  • Easterbrook, T.J., Reddin, K., Robinson, A., Modi, N., 1995, Studies on the immunogenicity of the Pla protein from Yersinia pestis. Contrib. Microbiol. Immunol. 13: 214–215.

    CAS  PubMed  Google Scholar 

  • Eyles, J.E., Williamson, E.D., Spiers, I.D., Stagg, A.J., Jones, S.M. and Alpar, H.O., 2000, Generation of protective immune responses to plague by mucosal administration of microsphere coencapsulated recombinant sub-units. J. Cont. Rel. 63: 191–200.

    CAS  Google Scholar 

  • Eyles, J.E., Bramwell, V.W., Williamson, E.D. and Alpar, H.O., 2001, Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration. Vaccine 19: 4732–4742.

    Article  CAS  PubMed  Google Scholar 

  • Galimand, M., Guiyoule, A., Gerbaud, G., Rasoamanana, B., Chanteau, S., Carniel, E., Courvalin, P., 1997, Multidrug resistance in Yersinia pestis mediated by a transferable plasmid. N. Engl. J. Med. 337: 677–680.

    Article  CAS  PubMed  Google Scholar 

  • Green, M., Rogers, D., Russell, P., Stagg, A.J., Bell, D.L., Eley, S.M., Titball, R.W., Williamson, E.D., 1999, The SCID/Beige mouse as a model to investigate protection against Yersinia pestis. FEMS Immunol. Med. Microbiol. 23: 107–113.

    CAS  PubMed  Google Scholar 

  • Hill, J., Leary, S.E.C., Griffin, K.F., Williamson, E.D. and Titball, R.W., 1997, Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunisation. Infect. Immun. 65: 4476–4482.

    CAS  PubMed  Google Scholar 

  • Jones, S.M., Griffin, K.F., Hodgson, I. and Williamson, E.D., 2002, Protective efficacy of a fully recombinant plague vaccine in the guinea pig. Vaccine, submitted.

    Google Scholar 

  • Leary, S.E.C., Williamson, E.D., Griffin, K.F., Russell, P., Eley, S.M and Titball, R.W., 1995, Active immunisation with recombinant V antigen from Yersinia pestis protects mice against plague. Infect. Immun. 63: 2854–2858.

    CAS  PubMed  Google Scholar 

  • Leary, S.E.C., Griffin, K.F., Garmory, H.S., Williamson, E.D. and Titball, R.W., 1997, Expression of an F1/V fusion protein in attenuated Salmonella typhimurium and protection of mice against plague. Microb. Pathog. 23: 167–179.

    CAS  PubMed  Google Scholar 

  • Leary, S.E.C. and Titball, R.W., 1998, Plague. Brit. Med. Bull. 54: 625–633.

    PubMed  Google Scholar 

  • Leary, S.E.C., Griffin, K.F., Galyov, E., Hewer, J., Williamson, E.D., Hölmström, A., Forsberg, A. and Titball, R.W., 1999, Yersinia outer proteins (YOPS) E,K and N are antigenic but non-protective compared to V antigen, in a murine model of bubonic plague. Microb. Pathog. 26: 159–169.

    CAS  PubMed  Google Scholar 

  • Meyer, K.F., 1970, Effectiveness of live or killed plague vaccines in man. Bull. World Health Organ. 42: 653–666.

    CAS  PubMed  Google Scholar 

  • Meyer, K.F., and Foster, L.E., 1948, Measurement of protective serum antibodies in human volunteers inoculated with plague prophylactics. Stanford Med. Bull. 6: 75–79.

    Google Scholar 

  • Miller, J., Williamson, E.D., Lakey, J.H., Pearce, M.J., Jones, S.M., and Titball, R.W., 1998, Macromolecular organisation of recombinant Yersinia pestis F1 antigen and the effect of structure on immunogenicity. FEMS Immunol. Med. Microbiol. 21: 213–221.

    CAS  PubMed  Google Scholar 

  • Montie, T.C., and Montie, D.B., 1971, Protein toxins of Pasturella pestis. Subunit composition and acid binding. Biochemistry 10: 2094–2100.

    Article  CAS  PubMed  Google Scholar 

  • Nakajima, R., Motin, V.L., and Brubaker, R.R., 1995, Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization. Infect. Immun. 63: 3021–3029.

    CAS  PubMed  Google Scholar 

  • Nemeth, J., and Straley, S.C., 1997, Effect of Yersinia pestis YopM on experimental plague. Infect. Immun. 65: 924–930.

    CAS  PubMed  Google Scholar 

  • Payne, D.W., Oyston, P.C.F., and Williamson, E.D., Immunisation with pH6 antigen in the mouse is not protective (unpublished data).

    Google Scholar 

  • Pettersson, J., Holmström, A., Hill, J., Leary, S., Frithz-Lindsten, E., von Euler-Matell, A., Carlsson, E., Titball, R.W., Forsberg, A. and Wolf-Watz, H., 1999, The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation. Mol. Microbiol. 32: 961–976.

    Article  CAS  PubMed  Google Scholar 

  • Prior, J., Hitchin, P.G., Wiliamson, E.D., Reason, A.J., Morris, H.R., Dell, A., Wren, B. and Titball, R.W., 2001, Characterisation of the lipopolysaccharide of Yersinia pestis. Microbial. Pathog. 30: 49–57.

    CAS  Google Scholar 

  • Russell, P, Eley, S.M., Hibbs, S.E., Manchee, R.J., Stagg, A.J. and Titball, R.W., 1995, A comparison of plague vaccine, USP and EV76 vaccine induced protection against Yersinia pestis in a murine model. Vaccine 13: 1551–1556.

    CAS  PubMed  Google Scholar 

  • Simpson, W.J., Thomas, R.E., and Schwan, T.G., 1990, Recombinant capsular antigen (fraction 1) from Yersinia pestis induces a protective antibody response in BALB/c mice. Am. J. Trop. Med. Hyg. 43: 389–396.

    CAS  PubMed  Google Scholar 

  • Titball, R.W., Howells, A.M., Oyston, P.C.F., Williamson, E.D., 1997, Expression of the Yersinia pestis capsular antigen (F1 antigen) on the surface of an aroA mutant of Salmonella typhimurium induces high level protection against plague. Infect. Immun. 65: 1926–1930.

    CAS  PubMed  Google Scholar 

  • Titball, R.W., Eley, S., Williamson, E.D., and Dennis, D.T., 1999, Plague. In Vaccines (S.A. Plotkin and W.A. Orenstein, eds.), W.B. Saunders Company, Philadelphia, pp.734–742.

    Google Scholar 

  • Titball, R.W. and Williamson, E.D., 2001, Vaccination against bubonic and pneumonic plague. Vaccine 19: 4175–4184.

    Article  CAS  PubMed  Google Scholar 

  • Tito, M.A., Miller, J., Griffin, K.F., Williamson, E.D., Titball, R.W. and Robinson, C.V., 2001, Macromolecular organisation of the Yersinia pestis capsular F1-antigen: insights from time of flight mass spectrometry. Prot. Sci. 10: 2408–2413.

    CAS  Google Scholar 

  • Von Metz, E., Eisler, D.M., Hottle, G.A., 1971, Immunogenicity of plague vaccines in mice and guinea pigs. Appl. Microbiol. 22: 84–88.

    Google Scholar 

  • Weeks, S., Hill, J., Friedlander, A., Welkos, S., 2002, Anti-V antigen antibody protects macrophages from Yersinia pestis-induced cell death and promotes phagocytosis. Microb. Pathog. 32: 227–237.

    CAS  PubMed  Google Scholar 

  • Williamson, E.D., Eley, S.M., Griffin, K.F., Green, M., Russell, P., Leary, S.E.C., Oyston, P.C.F., Easterbrook, T., Reddin, K.M., Robinson, A. and Titball, R.W., 1995, A new improved sub-unit vaccine for plague: the basis of protection. FEMS Immunol. Med. Microbiol. 12: 223–230.

    CAS  PubMed  Google Scholar 

  • Williamson, E.D., Eley, S.M., Stagg, A.J., Green, M., Russell, P., Titball, R.W., 1997, A subunit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunised animals against pneumonic plague. Vaccine 15: 1079–1084.

    Article  CAS  PubMed  Google Scholar 

  • Williamson, E.D., Vesey, P.M., Gillhespy, K.J., Eley, S.M., Green, M. and Titball, R.W., 1999, An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model. Clin. Exp. Immunol. 116: 107–114.

    Article  CAS  PubMed  Google Scholar 

  • Williamson, E.D., Eley, S.M. Stagg, A.J., Green, M., Russell, P and Titball, R.W., 2001, A single dose sub-unit vaccine protects against pneumonic plague. Vaccine 19: 566–571.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK

    Richard W. Titball & E. Diane Williamson

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  1. Richard W. Titball
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  2. E. Diane Williamson
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Editors and Affiliations

  1. University of Helsinki, Helsinki, Finland

    Mikael Skurnik

  2. Hospital Son Dureta, Palma Mallorca, Spain

    José Antonio Bengoechea

  3. National Public Health Institute, Turku, Finland

    Kaisa Granfors

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© 2004 Kluwer Academic Publishers

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Titball, R.W., Williamson, E.D. (2004). Second and Third Generation Plague Vaccines. In: Skurnik, M., Bengoechea, J.A., Granfors, K. (eds) The Genus Yersinia. Advances in Experimental Medicine and Biology, vol 529. Springer, Boston, MA. https://doi.org/10.1007/0-306-48416-1_80

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  • DOI: https://doi.org/10.1007/0-306-48416-1_80

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-47759-1

  • Online ISBN: 978-0-306-48416-2

  • eBook Packages: Springer Book Archive

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