The Orexin/Hypocretin System

Physiology and Pathophysiology

Editors:

ISBN: 978-1-58829-444-9 (Print) 978-1-59259-950-9 (Online)

Table of contents (27 chapters)

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  1. Front Matter

    Pages i-xii

  2. History

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-10

      History and Overview of Orexin/Hypocretin Research

  3. Overview of the Orexin/Hypocretin Neuronal System

    1. Front Matter

      Pages 11-11

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      Book Chapter

      Pages 13-20

      Orexin and Orexin Receptors

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      Book Chapter

      Pages 21-43

      Orexin Projections and Localization of Orexin Receptors

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      Book Chapter

      Pages 45-60

      Neuronal Responses to Hypocretin/Orexin

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      Book Chapter

      Pages 61-70

      Afferent System of Orexin Neurons

  4. Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids

    1. Front Matter

      Pages 71-71

    2. No Access

      Book Chapter

      Pages 73-82

      Hypocretin Measurements in the CSF, and Blood and Brain Tissue

    3. No Access

      Book Chapter

      Pages 83-96

      Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTPγS Autoradiography

  5. Physiology

    1. Front Matter

      Pages 97-97

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      Book Chapter

      Pages 99-106

      Orexin System and Feeding Behavior

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      Book Chapter

      Pages 107-117

      Orexins and the Autonomic Nervous System

    4. No Access

      Book Chapter

      Pages 119-130

      Neuroendocrine Role of the Orexins (Hypocretins)

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      Book Chapter

      Pages 131-140

      The Orexin/Hypocretin System and Stress and Emotion

  6. Physiology

    1. Front Matter

      Pages 141-141

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      Book Chapter

      Pages 143-153

      Hypocretin as a Wakefulness Regulatory Peptide

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      Book Chapter

      Pages 155-173

      Hypocretin/Orexin Tonus and Vigilance Control

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      Book Chapter

      Pages 175-188

      Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance

    5. No Access

      Book Chapter

      Pages 189-207

      Orexin and Hypothalamic Control of Sleep and Waking

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      Book Chapter

      Pages 209-217

      Hypocretin/Orexin and Motor Function

  7. Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency

    1. Front Matter

      Pages 219-219

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      Book Chapter

      Pages 221-231

      Overview of Human Narcolepsy

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      Book Chapter

      Pages 233-253

      Canine Models of Narcolepsy

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      Book Chapter

      Pages 255-266

      Rodent Models of Human Narcolepsy-Cataplexy

  8. Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency

    1. Front Matter

      Pages 267-267

    2. No Access

      Book Chapter

      Pages 269-286

      Hypocretin Deficiency in Human Narcolepsy

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