Biomarkers in Breast Cancer

Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect

Editors:

ISBN: 978-1-58829-227-8 (Print) 978-1-59259-915-8 (Online)

Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi

  2. General Topics

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-15

      Guidelines for the Design of Clinical Studies for the Development and Validation of Therapeutically Relevant Biomarkers and Biomarker-Based Classification Systems

    3. No Access

      Book Chapter

      Pages 17-30

      Analytical Aspects of Biomarker Immunoassays in Cancer Research

    4. No Access

      Book Chapter

      Pages 31-44

      Tissue Microarrays

  3. Assays for Gene Expression and Post-Translational Protein Abnormalities

    1. Front Matter

      Pages 45-45

    2. No Access

      Book Chapter

      Pages 47-61

      Gene Expression Profiling with DNA Microarrays

  4. Assays for DNA Abnormalities

    1. Front Matter

      Pages 63-63

    2. No Access

      Book Chapter

      Pages 65-77

      Assays for Gene Amplification

  5. Tissue Predictive Biomakers

    1. Front Matter

      Pages 79-79

    2. No Access

      Book Chapter

      Pages 81-109

      Cell Kinetics

    3. No Access

      Book Chapter

      Pages 111-128

      Urokinase-Type Plasminogen Activator and PAI-1

    4. No Access

      Book Chapter

      Pages 129-157

      Predictive Value of c--erb-B2 for Endocrine Therapy and Chemotherapy in Breast Cancer

    5. No Access

      Book Chapter

      Pages 159-175

      erb-B2 as a Therapeutic Target

    6. No Access

      Book Chapter

      Pages 177-191

      The Epidermal Growth Factor Receptor Pathway as a Selective Molecular-Targeted Treatment in Human Breast Cancer

    7. No Access

      Book Chapter

      Pages 193-209

      p53 as a Prognostic and Predictive Indicator

  6. Predictive Biomarkers in Body Fluids

    1. Front Matter

      Pages 211-211

    2. No Access

      Book Chapter

      Pages 213-233

      Occult Metastatic Cells in Breast Cancer Patients

    3. No Access

      Book Chapter

      Pages 235-265

      Circulating HER2/neu

    4. No Access

      Book Chapter

      Pages 267-292

      Circulating Vascular Endothelial Growth Factor

    5. No Access

      Book Chapter

      Pages 293-321

      Detection of Early Tumor Dissemination in Patients With Breast Cancer

  7. Future Directions

    1. Front Matter

      Pages 323-323

    2. No Access

      Book Chapter

      Pages 325-331

      New Technologies/New Markers/New Challenges

  8. Back Matter

    Pages 333-341