Camptothecins in Cancer Therapy

Editors:

ISBN: 978-1-58829-027-4 (Print) 978-1-59259-866-3 (Online)

Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiii

  2. Biochemistry, Pharmacology, and Chemistry

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-21

      Mechanism of Action of Topoisomerase 1 Poisons

    3. No Access

      Book Chapter

      Pages 23-38

      Crystallographic Insight Into the Mechanism of Drug-Induced Topoisomerase I DNA Damage

    4. No Access

      Book Chapter

      Pages 39-59

      Inhibitors of Topoisomerase I Function

    5. No Access

      Book Chapter

      Pages 61-107

      Cytotoxic Mechanisms of Topoisomerase 1 Inhibitors

    6. No Access

      Book Chapter

      Pages 109-125

      Biochemical and Genetic Analyses of DNA Topoisomerase 1-Mediated DNA Damage

    7. No Access

      Book Chapter

      Pages 127-151

      Preclinical Models for Evaluating Topoisomerase I-Targeted Drugs

    8. No Access

      Book Chapter

      Pages 153-169

      Mechanisms of Resistance to Camptothecins

    9. No Access

      Book Chapter

      Pages 171-190

      Recent Advances in Camptothecin Drug Design and Delivery Strategies

  3. Clinical Perspectives

    1. Front Matter

      Pages 191-191

    2. No Access

      Book Chapter

      Pages 193-206

      Clinical Experience With 9-Aminocamptothecin

    3. No Access

      Book Chapter

      Pages 207-228

      Clinical Studies of Rubitecan (9-Nitro 20(S) Camptothecin)

    4. No Access

      Book Chapter

      Pages 229-262

      Irinotecan

    5. No Access

      Book Chapter

      Pages 263-299

      Clinical Experience With Topotecan

    6. No Access

      Book Chapter

      Pages 301-316

      The Clinical Development of Lurtotecan

    7. No Access

      Book Chapter

      Pages 317-341

      Preclinical and Clinical Development of Exatecan (DX-951f)

    8. No Access

      Book Chapter

      Pages 343-367

      Camptothecins in the Treatment of Primary Brain Tumors

    9. No Access

      Book Chapter

      Pages 369-419

      Camptothecins in the Treatment of Lung Cancer

    10. No Access

      Book Chapter

      Pages 421-450

      Use of Camptothecins in the Treatment of Leukemia and Related Disorders

  4. Back Matter

    Pages 451-460