Suicide Gene Therapy

Methods and Reviews

Editors:

ISBN: 978-0-89603-971-1 (Print) 978-1-59259-429-0 (Online)

Table of contents (27 protocols)

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  1. Front Matter

    Pages i-xiv

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    Pages 1-27

    Introduction to the Background, Principles, and State of the Art in Suicide Gene Therapy

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    Pages 29-45

    Introduction to Vectors for Suicide Gene Therapy

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    Pages 47-59

    Construction of VNP20009

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    Pages 61-70

    Nonreplicating DNA Viral Vectors for Suicide Gene Therapy

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    Pages 71-90

    Replication-Selective Oncolytic Adenoviruses

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    Pages 91-106

    Retroviral Vectors for Suicide Gene Therapy

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    Pages 107-137

    Nonviral Liposomes

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    Pages 139-160

    Peptide- and Polymer-Based Gene Delivery Vehicles

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    Pages 161-202

    Design of Prodrugs for Suicide Gene Therapy

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    Pages 203-222

    Cytochrome P450-Based Gene Therapies for Cancer

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    Pages 223-245

    Tumor Sensitization to Purine Analogs by E. coli PNP

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    Pages 247-262

    Enzyme-Prodrug Systems

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    Pages 263-278

    Enzyme-Prodrug Systems

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    Pages 279-301

    Methods to Improve Efficacy in Suicide Gene Therapy Approaches

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    Pages 303-330

    Extracellular β-Glucuronidase for Gene-Directed Enzyme-Prodrug Therapy

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    Pages 331-344

    Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis

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    Pages 345-352

    Combination Suicide Gene Therapy

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    Pages 353-369

    Immune Response to Suicide Gene Therapy

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    Pages 371-387

    Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus

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    Pages 389-402

    Radiation-Activated Antitumor Vectors

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