Diabetes and Cardiovascular Disease

1. Front Matter

   Pages i-xvii

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2. Pathophysiology

   1. Effects of Insulin on the Vascular System

      • Helmut O. Steinbergr

      Pages 1-24

   2. Effects of Diabetes and Insulin Resistance on Endothelial Functions

      • Zhiheng He, Keiko Naruse, George L. King

      Pages 25-46

   3. Diabetes and Advanced Glycoxidation End-Products

      • Melpomeni Peppa, Jaime Uribarri, Helen Vlassara

      Pages 47-71

   4. The Renin—Angiotensin System in Diabetic Cardiovascular Complications

      • Edward P. Feener

      Pages 73-91

   5. PPARs and Their Emerging Role in Vascular Biology, Inflammation, and Atherosclerosis

      • Jorge Plutzky

      Pages 93-105

   6. Diabetes and Thrombosis

      • David J. Schneider, Burton E. Sobel

      Pages 107-128

   7. Role of Estrogens in Vascular Disease in Diabetes

      • Agathocles Tsatsoulis, Panayiotis Economides

      Pages 129-165

   8. Poly(ADP-Ribose) Polymerase Activation and Nitrosative Stress in the Development of Cardiovascular Disease in Diabetes

      • Pál Pacher, Csaba Szabó

      Pages 167-190

   9. Adiponectin and the Cardiovascular System

      • Suketu Shah, Alina Gavrila, Christos S. Mantzoros

      Pages 191-200

   10. Nitric Oxide and Its Role in Diabetes Mellitus

       • Michael T. Johnstone, Eli V. Gelfand

       Pages 201-224

   11. Diabetes and Atherosclerosis

       • Maria F. Lopes-Virella, Gabriel Virella

       Pages 225-258

   12. The Use of Animal Models to Study Diabetes and Atherosclerosis and Potential Anti-Atherosclerotic Therapies

       • Peter D. Reaven, Wulf Palinski

       Pages 259-280

3. Clinical

   1. Risk Factors

      1. The Metabolic Syndrome and Vascular Disease

         • S. J. Creely, Aresh J. Anwar, Sudhesh Kumar

         Pages 281-306

      2. Diabetes and Hypertension

         • Samy I. McFarlane, Amal F. Farag, David Gardner, James R. Sowers

         Pages 307-328

      3. Diabetes and Dyslipidemia

         • Asha Thomas-Geevarghese, Catherine Tuck, Henry N. Ginsberg

         Pages 329-347

   2. Microcirculation

      1. Diabetic Retinopathy

         • Lloyd Paul Aiello, Jerry Cavallerano

         Pages 349-365

      2. Diabetic Nephropathy

         • Richard’ J. Solomon, Bijan Roshan

         Pages 367-380

      3. Diabetic Neuropathy

         • Rayaz A. Malik, Aristidis Veves

         Pages 381-401

      4. Microcirculation of the Diabetic Foot

         • Chantel Hile, Aristidis Veves

         Pages 403-418

The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.

• Diabetes
• Diabetes mellitus
• Insulin
• cardiovascular
• hypertension

Reviews of the Second Edition

". . .provides a great resource for readers needing to learn more about the relationship between these disease entities. The book is recommended for any series student of diabetes. In particular, cardiologists and cardiology fellows, as well as cardiovascular surgeons and fellows, should be familiar with the material in it. It is also a valuable resource for those with more advanced knowledge of diabetes, such as endocrinologists and researchers active in the field of diabetes and cardiovascular diseases." -The New England Journal of Medicine

"This second edition is a timely work by many eminent contributors. It summarizes the vast knowledge about diabetes mellitus and cardiovascular disease into one volume." - Doody's Health Sciences Book Review Journal

From Reviews of the First Edition...

"All practicing clinicians would find some value in this text, but especially cardiologists and internal medicine practitioners as well as vascular specialists. Family medicine physicians and medical students would find it a good reference. . .This is indeed a comprehensive review of the vascular implications of diabetes. It is an important book because of the increasing prevalence of diabetes in our society. The book provides a good starting point for researchers since one can be struck after reading it that there are many opportunities for investigation presented here. It is a worthwhile addition to the medical literature. "-Doody's Health Sciences Book Review Journal

"...covers the range of problems, both clinical and biochemical, that arise in the cardiovascular system of those with diabetes. I highly recommend the book to interested medical students and residents and all clinicians who work with patients with diabetes." - Canadian Family Physician

"...could serve as a clinical textbook as well as a source and stimulus for further research in the field of diabetes associatedcardiovascular disease. It addresses the needs of general physicians, specialists and medical students." -Diabetologia

"...particularly timely...fills a need in the scientific literature that is only now beginning to be appreciated." -Preventive Cardiology

"....highly recommended to clinicians as well as to researchers interested in diabetes." -Acta Cardiologica

"...a comprehensive review of the vascular implications of diabetes...a worthwhile addition to the medical literature." -Doody's Health Sciences Book Review Journal

"...could serve as a clinical textbook as well as a source and stimulus for further research in the field of diabetes associated cardiovascular disease. It addresses the needs of general physicians, specialists and medical students." -Diabetologia

• Beth Israel Deaconess Medical Center, Harvard Medical School, Boston

  Michael T. Johnstone, Aristidis Veves

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